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Protein

UPF0056 inner membrane protein MarC

Gene

marC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:EG11637-MONOMER.
ECOL316407:JW1522-MONOMER.

Protein family/group databases

TCDBi2.A.95.1.1. the 6tms neutral amino acid transporter (naat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0056 inner membrane protein MarC
Gene namesi
Name:marC
Synonyms:ydeB, ydeC
Ordered Locus Names:b1529, JW1522
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11637. marC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77PeriplasmicSequence analysis
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Topological domaini29 – 4416CytoplasmicSequence analysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence analysisAdd
BLAST
Topological domaini66 – 683PeriplasmicSequence analysis
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Topological domaini90 – 11829CytoplasmicSequence analysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence analysisAdd
BLAST
Topological domaini140 – 15415PeriplasmicSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Topological domaini176 – 19621CytoplasmicSequence analysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence analysisAdd
BLAST
Topological domaini218 – 2214PeriplasmicSequence analysis

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoliWiki
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221UPF0056 inner membrane protein MarCPRO_0000156897Add
BLAST

Proteomic databases

PaxDbiP0AEY1.

Interactioni

Protein-protein interaction databases

BioGridi4259109. 12 interactions.
STRINGi511145.b1529.

Structurei

3D structure databases

ProteinModelPortaliP0AEY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0056 (MarC) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41082NP. Bacteria.
COG2095. LUCA.
HOGENOMiHOG000112971.
InParanoidiP0AEY1.
KOiK05595.
OMAiLWISLRS.
OrthoDBiEOG6KWZ3Q.
PhylomeDBiP0AEY1.

Family and domain databases

InterProiIPR002771. Multi_antbiot-R_MarC.
[Graphical view]
PfamiPF01914. MarC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00427. TIGR00427. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AEY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDLFKAIGL GLVVLLPLAN PLTTVALFLG LAGNMNSAER NRQSLMASVY
60 70 80 90 100
VFAIMMVAYY AGQLVMDTFG ISIPGLRIAG GLIVAFIGFR MLFPQQKAID
110 120 130 140 150
SPEAKSKSEE LEDEPSANIA FVPLAMPSTA GPGTIAMIIS SASTVRQSST
160 170 180 190 200
FADWVLMVAP PLIFFLVAVI LWGSLRSSGA IMRLVGKGGI EAISRLMGFL
210 220
LVCMGVQFII NGILEIIKTY H
Length:221
Mass (Da):23,617
Last modified:December 20, 2005 - v1
Checksum:i7957FF9403C5F135
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96235 Genomic DNA. Translation: AAC16396.1.
U00096 Genomic DNA. Translation: AAC74602.1.
AP009048 Genomic DNA. Translation: BAA15211.2.
PIRiD64907.
RefSeqiNP_416046.1. NC_000913.3.
WP_000885033.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74602; AAC74602; b1529.
BAA15211; BAA15211; BAA15211.
GeneIDi947132.
KEGGiecj:JW1522.
eco:b1529.
PATRICi32118356. VBIEscCol129921_1598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96235 Genomic DNA. Translation: AAC16396.1.
U00096 Genomic DNA. Translation: AAC74602.1.
AP009048 Genomic DNA. Translation: BAA15211.2.
PIRiD64907.
RefSeqiNP_416046.1. NC_000913.3.
WP_000885033.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AEY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259109. 12 interactions.
STRINGi511145.b1529.

Protein family/group databases

TCDBi2.A.95.1.1. the 6tms neutral amino acid transporter (naat) family.

Proteomic databases

PaxDbiP0AEY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74602; AAC74602; b1529.
BAA15211; BAA15211; BAA15211.
GeneIDi947132.
KEGGiecj:JW1522.
eco:b1529.
PATRICi32118356. VBIEscCol129921_1598.

Organism-specific databases

EchoBASEiEB1593.
EcoGeneiEG11637. marC.

Phylogenomic databases

eggNOGiENOG41082NP. Bacteria.
COG2095. LUCA.
HOGENOMiHOG000112971.
InParanoidiP0AEY1.
KOiK05595.
OMAiLWISLRS.
OrthoDBiEOG6KWZ3Q.
PhylomeDBiP0AEY1.

Enzyme and pathway databases

BioCyciEcoCyc:EG11637-MONOMER.
ECOL316407:JW1522-MONOMER.

Miscellaneous databases

PROiP0AEY1.

Family and domain databases

InterProiIPR002771. Multi_antbiot-R_MarC.
[Graphical view]
PfamiPF01914. MarC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00427. TIGR00427. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli."
    Cohen S.P., Haechler H., Levy S.B.
    J. Bacteriol. 175:1484-1492(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. Haechler H.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: GENE NAME.
  6. "Rapid topology mapping of Escherichia coli inner-membrane proteins by prediction and PhoA/GFP fusion analysis."
    Drew D., Sjoestrand D., Nilsson J., Urbig T., Chin C.-N., de Gier J.-W., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 99:2690-2695(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.
    Strain: K12 / JM109 / ATCC 53323.
  7. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.
  8. "The marC gene of Escherichia coli is not involved in multiple antibiotic resistance."
    McDermott P.F., McMurry L.M., Podglajen I., Dzink-Fox J.L., Schneiders T., Draper M.P., Levy S.B.
    Antimicrob. Agents Chemother. 52:382-383(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF INVOLVEMENT IN ANTIBIOTIC RESISTANCE.

Entry informationi

Entry nameiMARC_ECOLI
AccessioniPrimary (citable) accession number: P0AEY1
Secondary accession number(s): P31123, P31124, P77753
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: January 20, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be involved in multiple antibiotic resistance.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.