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Protein

Maltose-binding periplasmic protein

Gene

malE

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciECOO157:MALE-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Maltose-binding periplasmic protein
Alternative name(s):
MBP
MMBP
Maltodextrin-binding protein
Gene namesi
Name:malE
Ordered Locus Names:Z5632, ECs5017
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000004462227 – 396Maltose-binding periplasmic proteinAdd BLAST370

Proteomic databases

PRIDEiP0AEY0.

Interactioni

Protein-protein interaction databases

IntActiP0AEY0. 1 interactor.
MINTiMINT-6765486.
STRINGi155864.Z5632.

Structurei

Secondary structure

1396
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 36Combined sources4
Helixi43 – 57Combined sources15
Beta strandi61 – 64Combined sources4
Helixi69 – 77Combined sources9
Turni78 – 80Combined sources3
Beta strandi84 – 89Combined sources6
Helixi90 – 92Combined sources3
Helixi93 – 98Combined sources6
Helixi109 – 112Combined sources4
Helixi117 – 122Combined sources6
Beta strandi126 – 129Combined sources4
Beta strandi131 – 137Combined sources7
Beta strandi140 – 144Combined sources5
Turni145 – 147Combined sources3
Helixi155 – 157Combined sources3
Helixi158 – 166Combined sources9
Turni167 – 169Combined sources3
Beta strandi171 – 173Combined sources3
Beta strandi177 – 179Combined sources3
Helixi180 – 182Combined sources3
Helixi184 – 189Combined sources6
Beta strandi193 – 195Combined sources3
Beta strandi207 – 211Combined sources5
Helixi212 – 226Combined sources15
Helixi236 – 244Combined sources9
Beta strandi247 – 253Combined sources7
Helixi255 – 257Combined sources3
Helixi258 – 264Combined sources7
Beta strandi268 – 271Combined sources4
Beta strandi284 – 293Combined sources10
Helixi299 – 308Combined sources10
Turni309 – 311Combined sources3
Helixi313 – 320Combined sources8
Beta strandi327 – 330Combined sources4
Helixi331 – 337Combined sources7
Helixi341 – 352Combined sources12
Beta strandi353 – 355Combined sources3
Helixi362 – 377Combined sources16
Beta strandi379 – 381Combined sources3
Helixi383 – 392Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VD8X-ray2.07A27-384[»]
4MY2X-ray2.40A26-392[»]
4WGIX-ray1.85A27-392[»]
4WVGX-ray2.05A33-392[»]
4WVIX-ray1.90A33-392[»]
4WVJX-ray1.95A33-392[»]
4XAIX-ray2.60A/B27-392[»]
4XAJX-ray3.55A/B/C/D26-392[»]
4YS9X-ray2.00B27-392[»]
5CL1X-ray3.80A/B26-392[»]
5E7UX-ray2.80A27-392[»]
ProteinModelPortaliP0AEY0.
SMRiP0AEY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107FKK. Bacteria.
COG2182. LUCA.
HOGENOMiHOG000055250.
KOiK10108.
OMAiWAWANID.

Family and domain databases

InterProiIPR006060. Maltose-bd.
IPR006061. SBP_1_CS.
[Graphical view]
PRINTSiPR00181. MALTOSEBP.
PROSITEiPS01037. SBP_BACTERIAL_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AEY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKTGARIL ALSALTTMMF SASALAKIEE GKLVIWINGD KGYNGLAEVG
60 70 80 90 100
KKFEKDTGIK VTVEHPDKLE EKFPQVAATG DGPDIIFWAH DRFGGYAQSG
110 120 130 140 150
LLAEITPDKA FQDKLYPFTW DAVRYNGKLI AYPIAVEALS LIYNKDLLPN
160 170 180 190 200
PPKTWEEIPA LDKELKAKGK SALMFNLQEP YFTWPLIAAD GGYAFKYENG
210 220 230 240 250
KYDIKDVGVD NAGAKAGLTF LVDLIKNKHM NADTDYSIAE AAFNKGETAM
260 270 280 290 300
TINGPWAWSN IDTSKVNYGV TVLPTFKGQP SKPFVGVLSA GINAASPNKE
310 320 330 340 350
LAKEFLENYL LTDEGLEAVN KDKPLGAVAL KSYEEELAKD PRIAATMENA
360 370 380 390
QKGEIMPNIP QMSAFWYAVR TAVINAASGR QTVDEALKDA QTRITK
Length:396
Mass (Da):43,388
Last modified:July 21, 1986 - v1
Checksum:iA4C1B3C1777ADE47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG59233.1.
BA000007 Genomic DNA. Translation: BAB38440.1.
PIRiA98256.
E86096.
RefSeqiNP_313044.1. NC_002695.1.
WP_000695387.1. NZ_LPWC02000002.1.

Genome annotation databases

EnsemblBacteriaiAAG59233; AAG59233; Z5632.
BAB38440; BAB38440; BAB38440.
GeneIDi914317.
KEGGiece:Z5632.
ecs:ECs5017.
PATRICi18359629. VBIEscCol44059_4951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG59233.1.
BA000007 Genomic DNA. Translation: BAB38440.1.
PIRiA98256.
E86096.
RefSeqiNP_313044.1. NC_002695.1.
WP_000695387.1. NZ_LPWC02000002.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VD8X-ray2.07A27-384[»]
4MY2X-ray2.40A26-392[»]
4WGIX-ray1.85A27-392[»]
4WVGX-ray2.05A33-392[»]
4WVIX-ray1.90A33-392[»]
4WVJX-ray1.95A33-392[»]
4XAIX-ray2.60A/B27-392[»]
4XAJX-ray3.55A/B/C/D26-392[»]
4YS9X-ray2.00B27-392[»]
5CL1X-ray3.80A/B26-392[»]
5E7UX-ray2.80A27-392[»]
ProteinModelPortaliP0AEY0.
SMRiP0AEY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0AEY0. 1 interactor.
MINTiMINT-6765486.
STRINGi155864.Z5632.

Proteomic databases

PRIDEiP0AEY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG59233; AAG59233; Z5632.
BAB38440; BAB38440; BAB38440.
GeneIDi914317.
KEGGiece:Z5632.
ecs:ECs5017.
PATRICi18359629. VBIEscCol44059_4951.

Phylogenomic databases

eggNOGiENOG4107FKK. Bacteria.
COG2182. LUCA.
HOGENOMiHOG000055250.
KOiK10108.
OMAiWAWANID.

Enzyme and pathway databases

BioCyciECOO157:MALE-MONOMER.

Family and domain databases

InterProiIPR006060. Maltose-bd.
IPR006061. SBP_1_CS.
[Graphical view]
PRINTSiPR00181. MALTOSEBP.
PROSITEiPS01037. SBP_BACTERIAL_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMALE_ECO57
AccessioniPrimary (citable) accession number: P0AEY0
Secondary accession number(s): P02928
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.