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P0AEY0

- MALE_ECO57

UniProt

P0AEY0 - MALE_ECO57

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Protein

Maltose-binding periplasmic protein

Gene

malE

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides By similarity.By similarity

GO - Molecular functioni

  1. maltose transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciECOL386585:GJFA-5020-MONOMER.
ECOO157:MALE-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Maltose-binding periplasmic protein
Alternative name(s):
MBP
MMBP
Maltodextrin-binding protein
Gene namesi
Name:malE
Ordered Locus Names:Z5632, ECs5017
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 396370Maltose-binding periplasmic proteinPRO_0000044622Add
BLAST

Proteomic databases

PRIDEiP0AEY0.

Interactioni

Protein-protein interaction databases

IntActiP0AEY0. 1 interaction.
MINTiMINT-6765486.
STRINGi155864.Z5632.

Structurei

Secondary structure

1
396
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi32 – 365
Helixi43 – 5715
Beta strandi61 – 644
Helixi69 – 768
Turni77 – 804
Beta strandi84 – 896
Helixi90 – 923
Helixi93 – 986
Helixi109 – 1124
Helixi117 – 1226
Beta strandi131 – 1377
Beta strandi140 – 1445
Turni145 – 1473
Beta strandi153 – 1553
Helixi158 – 1669
Turni167 – 1693
Beta strandi171 – 1733
Helixi180 – 18910
Beta strandi193 – 1986
Beta strandi201 – 2088
Helixi212 – 22615
Helixi236 – 2449
Beta strandi247 – 2537
Helixi255 – 2573
Helixi258 – 2636
Beta strandi268 – 2714
Beta strandi284 – 29310
Helixi299 – 30810
Helixi313 – 32210
Beta strandi326 – 3305
Helixi331 – 3377
Helixi341 – 35111
Beta strandi353 – 3553
Helixi362 – 37716
Beta strandi378 – 3814
Turni383 – 3853
Helixi387 – 3926

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VD8X-ray2.07A27-384[»]
4MY2X-ray2.40A26-392[»]
ProteinModelPortaliP0AEY0.
SMRiP0AEY0. Positions 27-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2182.
HOGENOMiHOG000055250.
KOiK10108.
OMAiDAVRYDG.
OrthoDBiEOG6CCH2B.

Family and domain databases

InterProiIPR006060. Maltose-bd.
IPR006059. Solute-bd_1_bac.
IPR006061. Solute-bd_1_bac_CS.
[Graphical view]
PfamiPF01547. SBP_bac_1. 1 hit.
[Graphical view]
PRINTSiPR00181. MALTOSEBP.
PROSITEiPS01037. SBP_BACTERIAL_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AEY0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIKTGARIL ALSALTTMMF SASALAKIEE GKLVIWINGD KGYNGLAEVG
60 70 80 90 100
KKFEKDTGIK VTVEHPDKLE EKFPQVAATG DGPDIIFWAH DRFGGYAQSG
110 120 130 140 150
LLAEITPDKA FQDKLYPFTW DAVRYNGKLI AYPIAVEALS LIYNKDLLPN
160 170 180 190 200
PPKTWEEIPA LDKELKAKGK SALMFNLQEP YFTWPLIAAD GGYAFKYENG
210 220 230 240 250
KYDIKDVGVD NAGAKAGLTF LVDLIKNKHM NADTDYSIAE AAFNKGETAM
260 270 280 290 300
TINGPWAWSN IDTSKVNYGV TVLPTFKGQP SKPFVGVLSA GINAASPNKE
310 320 330 340 350
LAKEFLENYL LTDEGLEAVN KDKPLGAVAL KSYEEELAKD PRIAATMENA
360 370 380 390
QKGEIMPNIP QMSAFWYAVR TAVINAASGR QTVDEALKDA QTRITK
Length:396
Mass (Da):43,388
Last modified:July 21, 1986 - v1
Checksum:iA4C1B3C1777ADE47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG59233.1.
BA000007 Genomic DNA. Translation: BAB38440.1.
PIRiA98256.
E86096.
RefSeqiNP_290668.1. NC_002655.2.
NP_313044.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG59233; AAG59233; Z5632.
BAB38440; BAB38440; BAB38440.
GeneIDi914317.
960089.
KEGGiece:Z5632.
ecs:ECs5017.
PATRICi18359629. VBIEscCol44059_4951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG59233.1 .
BA000007 Genomic DNA. Translation: BAB38440.1 .
PIRi A98256.
E86096.
RefSeqi NP_290668.1. NC_002655.2.
NP_313044.1. NC_002695.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VD8 X-ray 2.07 A 27-384 [» ]
4MY2 X-ray 2.40 A 26-392 [» ]
ProteinModelPortali P0AEY0.
SMRi P0AEY0. Positions 27-392.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P0AEY0. 1 interaction.
MINTi MINT-6765486.
STRINGi 155864.Z5632.

Proteomic databases

PRIDEi P0AEY0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG59233 ; AAG59233 ; Z5632 .
BAB38440 ; BAB38440 ; BAB38440 .
GeneIDi 914317.
960089.
KEGGi ece:Z5632.
ecs:ECs5017.
PATRICi 18359629. VBIEscCol44059_4951.

Phylogenomic databases

eggNOGi COG2182.
HOGENOMi HOG000055250.
KOi K10108.
OMAi DAVRYDG.
OrthoDBi EOG6CCH2B.

Enzyme and pathway databases

BioCyci ECOL386585:GJFA-5020-MONOMER.
ECOO157:MALE-MONOMER.

Family and domain databases

InterProi IPR006060. Maltose-bd.
IPR006059. Solute-bd_1_bac.
IPR006061. Solute-bd_1_bac_CS.
[Graphical view ]
Pfami PF01547. SBP_bac_1. 1 hit.
[Graphical view ]
PRINTSi PR00181. MALTOSEBP.
PROSITEi PS01037. SBP_BACTERIAL_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiMALE_ECO57
AccessioniPrimary (citable) accession number: P0AEY0
Secondary accession number(s): P02928
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3