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Protein

Maltose/maltodextrin-binding periplasmic protein

Gene

malE

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins.By similarity

GO - Molecular functioni

Keywordsi

Biological processSugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Maltose/maltodextrin-binding periplasmic proteinBy similarity
Alternative name(s):
MMBPBy similarity
Maltodextrin-binding proteinBy similarity
Maltose-binding proteinBy similarity
Short name:
MBPBy similarity
Gene namesi
Name:malE
Ordered Locus Names:Z5632, ECs5017
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Periplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000004462227 – 396Maltose/maltodextrin-binding periplasmic proteinAdd BLAST370

Proteomic databases

PRIDEiP0AEY0

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE).By similarity

Protein-protein interaction databases

IntActiP0AEY0, 1 interactor
MINTiP0AEY0
STRINGi155864.Z5632

Structurei

Secondary structure

1396
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 36Combined sources4
Helixi43 – 57Combined sources15
Beta strandi61 – 64Combined sources4
Helixi69 – 77Combined sources9
Turni78 – 80Combined sources3
Beta strandi84 – 89Combined sources6
Helixi90 – 92Combined sources3
Helixi93 – 98Combined sources6
Helixi109 – 112Combined sources4
Helixi117 – 122Combined sources6
Beta strandi126 – 129Combined sources4
Beta strandi131 – 137Combined sources7
Beta strandi140 – 144Combined sources5
Turni145 – 147Combined sources3
Helixi155 – 157Combined sources3
Helixi158 – 166Combined sources9
Turni167 – 169Combined sources3
Beta strandi171 – 173Combined sources3
Beta strandi177 – 179Combined sources3
Helixi180 – 182Combined sources3
Helixi184 – 189Combined sources6
Beta strandi193 – 195Combined sources3
Beta strandi207 – 211Combined sources5
Helixi212 – 226Combined sources15
Helixi236 – 244Combined sources9
Beta strandi247 – 253Combined sources7
Helixi255 – 257Combined sources3
Helixi258 – 264Combined sources7
Beta strandi268 – 271Combined sources4
Beta strandi284 – 293Combined sources10
Helixi299 – 308Combined sources10
Turni309 – 311Combined sources3
Helixi313 – 320Combined sources8
Beta strandi327 – 330Combined sources4
Helixi331 – 337Combined sources7
Helixi341 – 352Combined sources12
Beta strandi353 – 355Combined sources3
Helixi362 – 377Combined sources16
Beta strandi379 – 381Combined sources3
Helixi383 – 392Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VD8X-ray2.07A27-384[»]
4MY2X-ray2.40A26-392[»]
4WGIX-ray1.85A27-392[»]
4WVGX-ray2.05A33-392[»]
4WVIX-ray1.90A33-392[»]
4WVJX-ray1.95A33-392[»]
4XAIX-ray2.60A/B27-392[»]
4XAJX-ray3.55A/B/C/D26-392[»]
4YS9X-ray2.00B27-392[»]
5CL1X-ray3.80A/B26-392[»]
5E7UX-ray2.80A27-392[»]
5JONX-ray2.04A/B27-392[»]
5LOFX-ray2.20A27-392[»]
ProteinModelPortaliP0AEY0
SMRiP0AEY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107FKK Bacteria
COG2182 LUCA
HOGENOMiHOG000055250
KOiK10108
OMAiWAHDWIG

Family and domain databases

InterProiView protein in InterPro
IPR006060 Maltose/Cyclodextrin-bd
IPR006059 SBP
IPR006061 SBP_1_CS
PfamiView protein in Pfam
PF13416 SBP_bac_8, 1 hit
PRINTSiPR00181 MALTOSEBP
PROSITEiView protein in PROSITE
PS01037 SBP_BACTERIAL_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AEY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKTGARIL ALSALTTMMF SASALAKIEE GKLVIWINGD KGYNGLAEVG
60 70 80 90 100
KKFEKDTGIK VTVEHPDKLE EKFPQVAATG DGPDIIFWAH DRFGGYAQSG
110 120 130 140 150
LLAEITPDKA FQDKLYPFTW DAVRYNGKLI AYPIAVEALS LIYNKDLLPN
160 170 180 190 200
PPKTWEEIPA LDKELKAKGK SALMFNLQEP YFTWPLIAAD GGYAFKYENG
210 220 230 240 250
KYDIKDVGVD NAGAKAGLTF LVDLIKNKHM NADTDYSIAE AAFNKGETAM
260 270 280 290 300
TINGPWAWSN IDTSKVNYGV TVLPTFKGQP SKPFVGVLSA GINAASPNKE
310 320 330 340 350
LAKEFLENYL LTDEGLEAVN KDKPLGAVAL KSYEEELAKD PRIAATMENA
360 370 380 390
QKGEIMPNIP QMSAFWYAVR TAVINAASGR QTVDEALKDA QTRITK
Length:396
Mass (Da):43,388
Last modified:July 21, 1986 - v1
Checksum:iA4C1B3C1777ADE47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG59233.1
BA000007 Genomic DNA Translation: BAB38440.1
PIRiA98256
E86096
RefSeqiNP_313044.1, NC_002695.1
WP_000695387.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG59233; AAG59233; Z5632
BAB38440; BAB38440; BAB38440
GeneIDi914317
KEGGiece:Z5632
ecs:ECs5017
PATRICifig|386585.9.peg.5240

Similar proteinsi

Entry informationi

Entry nameiMALE_ECO57
AccessioniPrimary (citable) accession number: P0AEY0
Secondary accession number(s): P02928
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 20, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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