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P0AEY0

- MALE_ECO57

UniProt

P0AEY0 - MALE_ECO57

Protein

Maltose-binding periplasmic protein

Gene

malE

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides By similarity.By similarity

    GO - Molecular functioni

    1. maltose transmembrane transporter activity Source: InterPro

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-5020-MONOMER.
    ECOO157:MALE-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Maltose-binding periplasmic protein
    Alternative name(s):
    MBP
    MMBP
    Maltodextrin-binding protein
    Gene namesi
    Name:malE
    Ordered Locus Names:Z5632, ECs5017
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626By similarityAdd
    BLAST
    Chaini27 – 396370Maltose-binding periplasmic proteinPRO_0000044622Add
    BLAST

    Proteomic databases

    PRIDEiP0AEY0.

    Interactioni

    Protein-protein interaction databases

    IntActiP0AEY0. 1 interaction.
    MINTiMINT-6765486.
    STRINGi155864.Z5632.

    Structurei

    Secondary structure

    1
    396
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi32 – 365
    Helixi43 – 5715
    Beta strandi61 – 644
    Helixi69 – 768
    Turni77 – 804
    Beta strandi84 – 896
    Helixi90 – 923
    Helixi93 – 986
    Helixi109 – 1124
    Helixi117 – 1226
    Beta strandi131 – 1377
    Beta strandi140 – 1445
    Turni145 – 1473
    Beta strandi153 – 1553
    Helixi158 – 1669
    Turni167 – 1693
    Beta strandi171 – 1733
    Helixi180 – 18910
    Beta strandi193 – 1986
    Beta strandi201 – 2088
    Helixi212 – 22615
    Helixi236 – 2449
    Beta strandi247 – 2537
    Helixi255 – 2573
    Helixi258 – 2636
    Beta strandi268 – 2714
    Beta strandi284 – 29310
    Helixi299 – 30810
    Helixi313 – 32210
    Beta strandi326 – 3305
    Helixi331 – 3377
    Helixi341 – 35111
    Beta strandi353 – 3553
    Helixi362 – 37716
    Beta strandi378 – 3814
    Turni383 – 3853
    Helixi387 – 3926

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3VD8X-ray2.07A27-384[»]
    4MY2X-ray2.40A26-392[»]
    ProteinModelPortaliP0AEY0.
    SMRiP0AEY0. Positions 27-392.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2182.
    HOGENOMiHOG000055250.
    KOiK10108.
    OMAiDAVRYDG.
    OrthoDBiEOG6CCH2B.

    Family and domain databases

    InterProiIPR006060. Maltose-bd.
    IPR006059. Solute-bd_1_bac.
    IPR006061. Solute-bd_1_bac_CS.
    [Graphical view]
    PfamiPF01547. SBP_bac_1. 1 hit.
    [Graphical view]
    PRINTSiPR00181. MALTOSEBP.
    PROSITEiPS01037. SBP_BACTERIAL_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0AEY0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIKTGARIL ALSALTTMMF SASALAKIEE GKLVIWINGD KGYNGLAEVG    50
    KKFEKDTGIK VTVEHPDKLE EKFPQVAATG DGPDIIFWAH DRFGGYAQSG 100
    LLAEITPDKA FQDKLYPFTW DAVRYNGKLI AYPIAVEALS LIYNKDLLPN 150
    PPKTWEEIPA LDKELKAKGK SALMFNLQEP YFTWPLIAAD GGYAFKYENG 200
    KYDIKDVGVD NAGAKAGLTF LVDLIKNKHM NADTDYSIAE AAFNKGETAM 250
    TINGPWAWSN IDTSKVNYGV TVLPTFKGQP SKPFVGVLSA GINAASPNKE 300
    LAKEFLENYL LTDEGLEAVN KDKPLGAVAL KSYEEELAKD PRIAATMENA 350
    QKGEIMPNIP QMSAFWYAVR TAVINAASGR QTVDEALKDA QTRITK 396
    Length:396
    Mass (Da):43,388
    Last modified:July 21, 1986 - v1
    Checksum:iA4C1B3C1777ADE47
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG59233.1.
    BA000007 Genomic DNA. Translation: BAB38440.1.
    PIRiA98256.
    E86096.
    RefSeqiNP_290668.1. NC_002655.2.
    NP_313044.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG59233; AAG59233; Z5632.
    BAB38440; BAB38440; BAB38440.
    GeneIDi914317.
    960089.
    KEGGiece:Z5632.
    ecs:ECs5017.
    PATRICi18359629. VBIEscCol44059_4951.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG59233.1 .
    BA000007 Genomic DNA. Translation: BAB38440.1 .
    PIRi A98256.
    E86096.
    RefSeqi NP_290668.1. NC_002655.2.
    NP_313044.1. NC_002695.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3VD8 X-ray 2.07 A 27-384 [» ]
    4MY2 X-ray 2.40 A 26-392 [» ]
    ProteinModelPortali P0AEY0.
    SMRi P0AEY0. Positions 27-392.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P0AEY0. 1 interaction.
    MINTi MINT-6765486.
    STRINGi 155864.Z5632.

    Proteomic databases

    PRIDEi P0AEY0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG59233 ; AAG59233 ; Z5632 .
    BAB38440 ; BAB38440 ; BAB38440 .
    GeneIDi 914317.
    960089.
    KEGGi ece:Z5632.
    ecs:ECs5017.
    PATRICi 18359629. VBIEscCol44059_4951.

    Phylogenomic databases

    eggNOGi COG2182.
    HOGENOMi HOG000055250.
    KOi K10108.
    OMAi DAVRYDG.
    OrthoDBi EOG6CCH2B.

    Enzyme and pathway databases

    BioCyci ECOL386585:GJFA-5020-MONOMER.
    ECOO157:MALE-MONOMER.

    Family and domain databases

    InterProi IPR006060. Maltose-bd.
    IPR006059. Solute-bd_1_bac.
    IPR006061. Solute-bd_1_bac_CS.
    [Graphical view ]
    Pfami PF01547. SBP_bac_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00181. MALTOSEBP.
    PROSITEi PS01037. SBP_BACTERIAL_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiMALE_ECO57
    AccessioniPrimary (citable) accession number: P0AEY0
    Secondary accession number(s): P02928
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3