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Protein

High-affinity branched-chain amino acid transport system permease protein LivH

Gene

livH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane.

GO - Molecular functioni

  • branched-chain amino acid transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • branched-chain amino acid transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:LIVH-MONOMER.
ECOL316407:JW3422-MONOMER.
MetaCyc:LIVH-MONOMER.
RETL1328306-WGS:GSTH-3383-MONOMER.

Protein family/group databases

TCDBi3.A.1.4.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity branched-chain amino acid transport system permease protein LivH
Alternative name(s):
LIV-I protein H
Gene namesi
Name:livH
Ordered Locus Names:b3457, JW3422
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10538. livH.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121CytoplasmicSequence analysisAdd
BLAST
Transmembranei22 – 4221HelicalSequence analysisAdd
BLAST
Topological domaini43 – 453PeriplasmicSequence analysis
Transmembranei46 – 6621HelicalSequence analysisAdd
BLAST
Topological domaini67 – 682CytoplasmicSequence analysis
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Topological domaini90 – 10415PeriplasmicSequence analysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence analysisAdd
BLAST
Topological domaini126 – 15429CytoplasmicSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Topological domaini176 – 20328PeriplasmicSequence analysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence analysisAdd
BLAST
Topological domaini225 – 24521CytoplasmicSequence analysisAdd
BLAST
Transmembranei246 – 26621HelicalSequence analysisAdd
BLAST
Topological domaini267 – 28014PeriplasmicSequence analysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence analysisAdd
BLAST
Topological domaini302 – 3087CytoplasmicSequence analysis

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308High-affinity branched-chain amino acid transport system permease protein LivHPRO_0000060058Add
BLAST

Proteomic databases

PaxDbiP0AEX7.

Interactioni

Protein-protein interaction databases

BioGridi4262494. 23 interactions.
STRINGi511145.b3457.

Structurei

3D structure databases

ProteinModelPortaliP0AEX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C32. Bacteria.
COG0559. LUCA.
HOGENOMiHOG000202530.
InParanoidiP0AEX7.
KOiK01997.
OMAiLYYNTIN.
OrthoDBiEOG6H1Q47.
PhylomeDBiP0AEX7.

Family and domain databases

InterProiIPR001851. ABC_transp_permease.
[Graphical view]
PfamiPF02653. BPD_transp_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AEX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQFLYFLQ QMFNGVTLGS TYALIAIGYT MVYGIIGMIN FAHGEVYMIG
60 70 80 90 100
SYVSFMIIAA LMMMGIDTGW LLVAAGFVGA IVIASAYGWS IERVAYRPVR
110 120 130 140 150
NSKRLIALIS AIGMSIFLQN YVSLTEGSRD VALPSLFNGQ WVVGHSENFS
160 170 180 190 200
ASITTMQAVI WIVTFLAMLA LTIFIRYSRM GRACRACAED LKMASLLGIN
210 220 230 240 250
TDRVIALTFV IGAAMAAVAG VLLGQFYGVI NPYIGFMAGM KAFTAAVLGG
260 270 280 290 300
IGSIPGAMIG GLILGIAEAL SSAYLSTEYK DVVSFALLIL VLLVMPTGIL

GRPEVEKV
Length:308
Mass (Da):32,982
Last modified:December 20, 2005 - v1
Checksum:i8C8A4BD56718A4BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti253 – 2531S → G (PubMed:3009409).Curated
Sequence conflicti253 – 2531S → G (PubMed:2195019).Curated
Sequence conflicti288 – 2881L → P (PubMed:3009409).Curated
Sequence conflicti288 – 2881L → P (PubMed:2195019).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05516 Genomic DNA. Translation: AAA83884.1.
U00039 Genomic DNA. Translation: AAB18432.1.
U00096 Genomic DNA. Translation: AAC76482.1.
AP009048 Genomic DNA. Translation: BAE77836.1.
PIRiS47676. QRECLH.
RefSeqiNP_417914.1. NC_000913.3.
WP_001295111.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76482; AAC76482; b3457.
BAE77836; BAE77836; BAE77836.
GeneIDi947965.
KEGGiecj:JW3422.
eco:b3457.
PATRICi32122356. VBIEscCol129921_3555.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05516 Genomic DNA. Translation: AAA83884.1.
U00039 Genomic DNA. Translation: AAB18432.1.
U00096 Genomic DNA. Translation: AAC76482.1.
AP009048 Genomic DNA. Translation: BAE77836.1.
PIRiS47676. QRECLH.
RefSeqiNP_417914.1. NC_000913.3.
WP_001295111.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AEX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262494. 23 interactions.
STRINGi511145.b3457.

Protein family/group databases

TCDBi3.A.1.4.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0AEX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76482; AAC76482; b3457.
BAE77836; BAE77836; BAE77836.
GeneIDi947965.
KEGGiecj:JW3422.
eco:b3457.
PATRICi32122356. VBIEscCol129921_3555.

Organism-specific databases

EchoBASEiEB0533.
EcoGeneiEG10538. livH.

Phylogenomic databases

eggNOGiENOG4105C32. Bacteria.
COG0559. LUCA.
HOGENOMiHOG000202530.
InParanoidiP0AEX7.
KOiK01997.
OMAiLYYNTIN.
OrthoDBiEOG6H1Q47.
PhylomeDBiP0AEX7.

Enzyme and pathway databases

BioCyciEcoCyc:LIVH-MONOMER.
ECOL316407:JW3422-MONOMER.
MetaCyc:LIVH-MONOMER.
RETL1328306-WGS:GSTH-3383-MONOMER.

Miscellaneous databases

PROiP0AEX7.

Family and domain databases

InterProiIPR001851. ABC_transp_permease.
[Graphical view]
PfamiPF02653. BPD_transp_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of livH, the structural gene encoding a component of the leucine transport system in Escherichia coli."
    Nazos P.M., Antonucci T.K., Landick R., Oxender D.L.
    J. Bacteriol. 166:565-573(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence and genetic characterization reveal six essential genes for the LIV-I and LS transport systems of Escherichia coli."
    Adams M.D., Wagner L.M., Graddis T.J., Landick R., Antonucci T.K., Gibson A.L., Oxender D.L.
    J. Biol. Chem. 265:11436-11443(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."
    Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.
    Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiLIVH_ECOLI
AccessioniPrimary (citable) accession number: P0AEX7
Secondary accession number(s): P08340, Q2M7C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: December 20, 2005
Last modified: January 20, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.