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Protein

High-affinity branched-chain amino acid transport system permease protein LivH

Gene

livH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane.

GO - Molecular functioni

  • branched-chain amino acid transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • branched-chain amino acid transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:LIVH-MONOMER.
ECOL316407:JW3422-MONOMER.
MetaCyc:LIVH-MONOMER.

Protein family/group databases

TCDBi3.A.1.4.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity branched-chain amino acid transport system permease protein LivH
Alternative name(s):
LIV-I protein H
Gene namesi
Name:livH
Ordered Locus Names:b3457, JW3422
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10538. livH.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 45PeriplasmicSequence analysis3
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Topological domaini67 – 68CytoplasmicSequence analysis2
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 104PeriplasmicSequence analysisAdd BLAST15
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 154CytoplasmicSequence analysisAdd BLAST29
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 203PeriplasmicSequence analysisAdd BLAST28
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 245CytoplasmicSequence analysisAdd BLAST21
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 280PeriplasmicSequence analysisAdd BLAST14
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 308CytoplasmicSequence analysis7

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000600581 – 308High-affinity branched-chain amino acid transport system permease protein LivHAdd BLAST308

Proteomic databases

PaxDbiP0AEX7.
PRIDEiP0AEX7.

Interactioni

Protein-protein interaction databases

BioGridi4262494. 23 interactors.
STRINGi511145.b3457.

Structurei

3D structure databases

ProteinModelPortaliP0AEX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C32. Bacteria.
COG0559. LUCA.
HOGENOMiHOG000202530.
InParanoidiP0AEX7.
KOiK01997.
OMAiLMYYGVA.
PhylomeDBiP0AEX7.

Family and domain databases

InterProiIPR001851. ABC_transp_permease.
[Graphical view]
PfamiPF02653. BPD_transp_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AEX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQFLYFLQ QMFNGVTLGS TYALIAIGYT MVYGIIGMIN FAHGEVYMIG
60 70 80 90 100
SYVSFMIIAA LMMMGIDTGW LLVAAGFVGA IVIASAYGWS IERVAYRPVR
110 120 130 140 150
NSKRLIALIS AIGMSIFLQN YVSLTEGSRD VALPSLFNGQ WVVGHSENFS
160 170 180 190 200
ASITTMQAVI WIVTFLAMLA LTIFIRYSRM GRACRACAED LKMASLLGIN
210 220 230 240 250
TDRVIALTFV IGAAMAAVAG VLLGQFYGVI NPYIGFMAGM KAFTAAVLGG
260 270 280 290 300
IGSIPGAMIG GLILGIAEAL SSAYLSTEYK DVVSFALLIL VLLVMPTGIL

GRPEVEKV
Length:308
Mass (Da):32,982
Last modified:December 20, 2005 - v1
Checksum:i8C8A4BD56718A4BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253S → G (PubMed:3009409).Curated1
Sequence conflicti253S → G (PubMed:2195019).Curated1
Sequence conflicti288L → P (PubMed:3009409).Curated1
Sequence conflicti288L → P (PubMed:2195019).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05516 Genomic DNA. Translation: AAA83884.1.
U00039 Genomic DNA. Translation: AAB18432.1.
U00096 Genomic DNA. Translation: AAC76482.1.
AP009048 Genomic DNA. Translation: BAE77836.1.
PIRiS47676. QRECLH.
RefSeqiNP_417914.1. NC_000913.3.
WP_001295111.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76482; AAC76482; b3457.
BAE77836; BAE77836; BAE77836.
GeneIDi947965.
KEGGiecj:JW3422.
eco:b3457.
PATRICi32122356. VBIEscCol129921_3555.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05516 Genomic DNA. Translation: AAA83884.1.
U00039 Genomic DNA. Translation: AAB18432.1.
U00096 Genomic DNA. Translation: AAC76482.1.
AP009048 Genomic DNA. Translation: BAE77836.1.
PIRiS47676. QRECLH.
RefSeqiNP_417914.1. NC_000913.3.
WP_001295111.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AEX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262494. 23 interactors.
STRINGi511145.b3457.

Protein family/group databases

TCDBi3.A.1.4.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0AEX7.
PRIDEiP0AEX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76482; AAC76482; b3457.
BAE77836; BAE77836; BAE77836.
GeneIDi947965.
KEGGiecj:JW3422.
eco:b3457.
PATRICi32122356. VBIEscCol129921_3555.

Organism-specific databases

EchoBASEiEB0533.
EcoGeneiEG10538. livH.

Phylogenomic databases

eggNOGiENOG4105C32. Bacteria.
COG0559. LUCA.
HOGENOMiHOG000202530.
InParanoidiP0AEX7.
KOiK01997.
OMAiLMYYGVA.
PhylomeDBiP0AEX7.

Enzyme and pathway databases

BioCyciEcoCyc:LIVH-MONOMER.
ECOL316407:JW3422-MONOMER.
MetaCyc:LIVH-MONOMER.

Miscellaneous databases

PROiP0AEX7.

Family and domain databases

InterProiIPR001851. ABC_transp_permease.
[Graphical view]
PfamiPF02653. BPD_transp_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIVH_ECOLI
AccessioniPrimary (citable) accession number: P0AEX7
Secondary accession number(s): P08340, Q2M7C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: December 20, 2005
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.