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Protein

Probable phosphoribulokinase

Gene

prkB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 20ATPBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12365-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoribulokinase (EC:2.7.1.19)
Short name:
PRK
Short name:
PRKase
Alternative name(s):
Phosphopentokinase
Gene namesi
Name:prkB
Synonyms:yhfF
Ordered Locus Names:b3355, JW3318
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12365 prkB

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002019521 – 289Probable phosphoribulokinaseAdd BLAST289

Proteomic databases

PaxDbiP0AEX5
PRIDEiP0AEX5

Interactioni

Protein-protein interaction databases

BioGridi4259590, 23 interactors
DIPiDIP-10565N
IntActiP0AEX5, 4 interactors
STRINGi316385.ECDH10B_3531

Structurei

3D structure databases

ProteinModelPortaliP0AEX5
SMRiP0AEX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphoribulokinase family.Curated

Phylogenomic databases

eggNOGiENOG4105CJE Bacteria
COG3954 LUCA
HOGENOMiHOG000272991
InParanoidiP0AEX5
KOiK00855
OMAiTDILFYE

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR006082 PRK
IPR006083 PRK/URK
PfamiView protein in Pfam
PF00485 PRK, 1 hit
PRINTSiPR00478 PHRIBLKINASE
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00567 PHOSPHORIBULOKINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P0AEX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKHPVIAV TGSSGAGTTT TSLAFRKIFA QLNLHAAEVE GDSFHRYTRP
60 70 80 90 100
EMDMAIRKAR DAGRHISYFG PEANDFGLLE QTFIEYGQSG KGKSRKYLHT
110 120 130 140 150
YDEAVPWNQV PGTFTPWQPL PEPTDVLFYE GLHGGVVTPQ HNVAQHVDLL
160 170 180 190 200
VGVVPIVNLE WIQKLIRDTS ERGHSREAVM DSVVRSMEDY INYITPQFSR
210 220 230 240 250
THLNFQRVPT VDTSNPFAAK GIPSLDESFV VIHFRNLEGI DFPWLLAMLQ
260 270 280
GSFISHINTL VVPGGKMGLA MELIMLPLVQ RLMEGKKIE
Length:289
Mass (Da):32,344
Last modified:December 20, 2005 - v1
Checksum:iA98EE1A322148DAE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250Q → L (PubMed:1756168).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58152.1 Frameshift.
U00096 Genomic DNA Translation: AAC76380.1
AP009048 Genomic DNA Translation: BAE77935.1
X61919 Genomic DNA No translation available.
PIRiF65129
RefSeqiNP_417814.1, NC_000913.3
WP_001274680.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76380; AAC76380; b3355
BAE77935; BAE77935; BAE77935
GeneIDi947862
KEGGiecj:JW3318
eco:b3355
PATRICifig|1411691.4.peg.3375

Similar proteinsi

Entry informationi

Entry nameiKPPR_ECOLI
AccessioniPrimary (citable) accession number: P0AEX5
Secondary accession number(s): P37307, P76684, Q2M721
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health