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Protein

Probable phosphoribulokinase

Gene

prkB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 20ATPBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12365-MONOMER.
ECOL316407:JW3318-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoribulokinase (EC:2.7.1.19)
Short name:
PRK
Short name:
PRKase
Alternative name(s):
Phosphopentokinase
Gene namesi
Name:prkB
Synonyms:yhfF
Ordered Locus Names:b3355, JW3318
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12365. prkB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002019521 – 289Probable phosphoribulokinaseAdd BLAST289

Proteomic databases

PaxDbiP0AEX5.
PRIDEiP0AEX5.

Interactioni

Protein-protein interaction databases

BioGridi4259590. 20 interactors.
DIPiDIP-10565N.
IntActiP0AEX5. 4 interactors.
MINTiMINT-1286728.
STRINGi511145.b3355.

Structurei

3D structure databases

ProteinModelPortaliP0AEX5.
SMRiP0AEX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphoribulokinase family.Curated

Phylogenomic databases

eggNOGiENOG4105CJE. Bacteria.
COG3954. LUCA.
HOGENOMiHOG000272991.
InParanoidiP0AEX5.
KOiK00855.
OMAiTDILFYE.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR006082. PRK.
IPR006083. PRK/URK.
[Graphical view]
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PRINTSiPR00478. PHRIBLKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00567. PHOSPHORIBULOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AEX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKHPVIAV TGSSGAGTTT TSLAFRKIFA QLNLHAAEVE GDSFHRYTRP
60 70 80 90 100
EMDMAIRKAR DAGRHISYFG PEANDFGLLE QTFIEYGQSG KGKSRKYLHT
110 120 130 140 150
YDEAVPWNQV PGTFTPWQPL PEPTDVLFYE GLHGGVVTPQ HNVAQHVDLL
160 170 180 190 200
VGVVPIVNLE WIQKLIRDTS ERGHSREAVM DSVVRSMEDY INYITPQFSR
210 220 230 240 250
THLNFQRVPT VDTSNPFAAK GIPSLDESFV VIHFRNLEGI DFPWLLAMLQ
260 270 280
GSFISHINTL VVPGGKMGLA MELIMLPLVQ RLMEGKKIE
Length:289
Mass (Da):32,344
Last modified:December 20, 2005 - v1
Checksum:iA98EE1A322148DAE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250Q → L (PubMed:1756168).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58152.1. Frameshift.
U00096 Genomic DNA. Translation: AAC76380.1.
AP009048 Genomic DNA. Translation: BAE77935.1.
X61919 Genomic DNA. No translation available.
PIRiF65129.
RefSeqiNP_417814.1. NC_000913.3.
WP_001274680.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76380; AAC76380; b3355.
BAE77935; BAE77935; BAE77935.
GeneIDi947862.
KEGGiecj:JW3318.
eco:b3355.
PATRICi32122144. VBIEscCol129921_3449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58152.1. Frameshift.
U00096 Genomic DNA. Translation: AAC76380.1.
AP009048 Genomic DNA. Translation: BAE77935.1.
X61919 Genomic DNA. No translation available.
PIRiF65129.
RefSeqiNP_417814.1. NC_000913.3.
WP_001274680.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AEX5.
SMRiP0AEX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259590. 20 interactors.
DIPiDIP-10565N.
IntActiP0AEX5. 4 interactors.
MINTiMINT-1286728.
STRINGi511145.b3355.

Proteomic databases

PaxDbiP0AEX5.
PRIDEiP0AEX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76380; AAC76380; b3355.
BAE77935; BAE77935; BAE77935.
GeneIDi947862.
KEGGiecj:JW3318.
eco:b3355.
PATRICi32122144. VBIEscCol129921_3449.

Organism-specific databases

EchoBASEiEB2268.
EcoGeneiEG12365. prkB.

Phylogenomic databases

eggNOGiENOG4105CJE. Bacteria.
COG3954. LUCA.
HOGENOMiHOG000272991.
InParanoidiP0AEX5.
KOiK00855.
OMAiTDILFYE.

Enzyme and pathway databases

BioCyciEcoCyc:EG12365-MONOMER.
ECOL316407:JW3318-MONOMER.

Miscellaneous databases

PROiP0AEX5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR006082. PRK.
IPR006083. PRK/URK.
[Graphical view]
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PRINTSiPR00478. PHRIBLKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00567. PHOSPHORIBULOKINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKPPR_ECOLI
AccessioniPrimary (citable) accession number: P0AEX5
Secondary accession number(s): P37307, P76684, Q2M721
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.