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Protein

Alpha-ketoglutarate permease

Gene

kgtP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system).1 Publication

GO - Molecular functioni

  • solute:cation symporter activity Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:KGTP-MONOMER.
ECOL316407:JW2571-MONOMER.
MetaCyc:KGTP-MONOMER.

Protein family/group databases

TCDBi2.A.1.6.2. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-ketoglutarate permease
Gene namesi
Name:kgtP
Synonyms:witA
Ordered Locus Names:b2587, JW2571
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10522. kgtP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232Cytoplasmic1 PublicationAdd
BLAST
Transmembranei33 – 5321Helical; Name=1CuratedAdd
BLAST
Topological domaini54 – 629Periplasmic1 Publication
Transmembranei63 – 8321Helical; Name=2CuratedAdd
BLAST
Topological domaini84 – 9512Cytoplasmic1 PublicationAdd
BLAST
Transmembranei96 – 11621Helical; Name=3CuratedAdd
BLAST
Topological domaini117 – 1182Periplasmic1 Publication
Transmembranei119 – 13921Helical; Name=4CuratedAdd
BLAST
Topological domaini140 – 16223Cytoplasmic1 PublicationAdd
BLAST
Transmembranei163 – 18321Helical; Name=5CuratedAdd
BLAST
Topological domaini184 – 19310Periplasmic1 Publication
Transmembranei194 – 21421Helical; Name=6CuratedAdd
BLAST
Topological domaini215 – 24329Cytoplasmic1 PublicationAdd
BLAST
Transmembranei244 – 26421Helical; Name=7CuratedAdd
BLAST
Topological domaini265 – 27915Periplasmic1 PublicationAdd
BLAST
Transmembranei280 – 30021Helical; Name=8CuratedAdd
BLAST
Topological domaini301 – 3099Cytoplasmic1 Publication
Transmembranei310 – 33021Helical; Name=9CuratedAdd
BLAST
Topological domaini331 – 3399Periplasmic1 Publication
Transmembranei340 – 36021Helical; Name=10CuratedAdd
BLAST
Topological domaini361 – 37313Cytoplasmic1 PublicationAdd
BLAST
Transmembranei374 – 39421Helical; Name=11CuratedAdd
BLAST
Topological domaini395 – 4028Periplasmic1 Publication
Transmembranei403 – 42321Helical; Name=12CuratedAdd
BLAST
Topological domaini424 – 4329Cytoplasmic1 Publication

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Alpha-ketoglutarate permeasePRO_0000050306Add
BLAST

Proteomic databases

PaxDbiP0AEX3.
PRIDEiP0AEX3.

Interactioni

Protein-protein interaction databases

BioGridi4260613. 6 interactions.
STRINGi511145.b2587.

Structurei

3D structure databases

ProteinModelPortaliP0AEX3.
SMRiP0AEX3. Positions 20-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CSH. Bacteria.
ENOG410XP7I. LUCA.
HOGENOMiHOG000141612.
InParanoidiP0AEX3.
KOiK03761.
OMAiIMTVALC.
PhylomeDBiP0AEX3.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004736. Cit_H_symport.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00883. 2A0106. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AEX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESTVTADS KLTSSDTRRR IWAIVGASSG NLVEWFDFYV YSFCSLYFAH
60 70 80 90 100
IFFPSGNTTT QLLQTAGVFA AGFLMRPIGG WLFGRIADKH GRKKSMLLSV
110 120 130 140 150
CMMCFGSLVI ACLPGYETIG TWAPALLLLA RLFQGLSVGG EYGTSATYMS
160 170 180 190 200
EVAVEGRKGF YASFQYVTLI GGQLLALLVV VVLQHTMEDA ALREWGWRIP
210 220 230 240 250
FALGAVLAVV ALWLRRQLDE TSQQETRALK EAGSLKGLWR NRRAFIMVLG
260 270 280 290 300
FTAAGSLCFY TFTTYMQKYL VNTAGMHANV ASGIMTAALF VFMLIQPLIG
310 320 330 340 350
ALSDKIGRRT SMLCFGSLAA IFTVPILSAL QNVSSPYAAF GLVMCALLIV
360 370 380 390 400
SFYTSISGIL KAEMFPAQVR ALGVGLSYAV ANAIFGGSAE YVALSLKSIG
410 420 430
METAFFWYVT LMAVVAFLVS LMLHRKGKGM RL
Length:432
Mass (Da):47,052
Last modified:December 20, 2005 - v1
Checksum:i264B8473195765DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53027 Genomic DNA. Translation: CAA37198.1.
U00096 Genomic DNA. Translation: AAC75640.1.
AP009048 Genomic DNA. Translation: BAA16472.1.
X56780 Genomic DNA. Translation: CAA40099.1. Different termination.
X52363 Genomic DNA. Translation: CAA36589.1.
PIRiJN0080.
RefSeqiNP_417082.1. NC_000913.3.
WP_000841103.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75640; AAC75640; b2587.
BAA16472; BAA16472; BAA16472.
GeneIDi947069.
KEGGiecj:JW2571.
eco:b2587.
PATRICi32120575. VBIEscCol129921_2690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53027 Genomic DNA. Translation: CAA37198.1.
U00096 Genomic DNA. Translation: AAC75640.1.
AP009048 Genomic DNA. Translation: BAA16472.1.
X56780 Genomic DNA. Translation: CAA40099.1. Different termination.
X52363 Genomic DNA. Translation: CAA36589.1.
PIRiJN0080.
RefSeqiNP_417082.1. NC_000913.3.
WP_000841103.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AEX3.
SMRiP0AEX3. Positions 20-382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260613. 6 interactions.
STRINGi511145.b2587.

Protein family/group databases

TCDBi2.A.1.6.2. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP0AEX3.
PRIDEiP0AEX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75640; AAC75640; b2587.
BAA16472; BAA16472; BAA16472.
GeneIDi947069.
KEGGiecj:JW2571.
eco:b2587.
PATRICi32120575. VBIEscCol129921_2690.

Organism-specific databases

EchoBASEiEB0517.
EcoGeneiEG10522. kgtP.

Phylogenomic databases

eggNOGiENOG4105CSH. Bacteria.
ENOG410XP7I. LUCA.
HOGENOMiHOG000141612.
InParanoidiP0AEX3.
KOiK03761.
OMAiIMTVALC.
PhylomeDBiP0AEX3.

Enzyme and pathway databases

BioCyciEcoCyc:KGTP-MONOMER.
ECOL316407:JW2571-MONOMER.
MetaCyc:KGTP-MONOMER.

Miscellaneous databases

PROiP0AEX3.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004736. Cit_H_symport.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00883. 2A0106. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKGTP_ECOLI
AccessioniPrimary (citable) accession number: P0AEX3
Secondary accession number(s): P17448
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.