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Protein

1-phosphofructokinase

Gene

fruK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei255Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi187 – 190ATPSequence analysis4

GO - Molecular functioni

  • 1-phosphofructokinase activity Source: EcoCyc
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • fructose catabolic process Source: EcoCyc

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:1-PFK-MONOMER
MetaCyc:1-PFK-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphofructokinase (EC:2.7.1.56)
Alternative name(s):
Fructose 1-phosphate kinase
Gene namesi
Name:fruK
Synonyms:fpk
Ordered Locus Names:b2168, JW2155
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10337 fruK

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000800761 – 3121-phosphofructokinaseAdd BLAST312

Proteomic databases

PaxDbiP0AEW9
PRIDEiP0AEW9

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi4262911, 23 interactors
IntActiP0AEW9, 2 interactors
STRINGi316385.ECDH10B_2325

Structurei

3D structure databases

ProteinModelPortaliP0AEW9
SMRiP0AEW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the carbohydrate kinase PfkB family.Curated

Phylogenomic databases

eggNOGiENOG4105DE4 Bacteria
COG1105 LUCA
HOGENOMiHOG000265280
InParanoidiP0AEW9
KOiK00882
OMAiGETRSNI
PhylomeDBiP0AEW9

Family and domain databases

CDDicd01164 FruK_PfkB_like, 1 hit
Gene3Di3.40.1190.20, 1 hit
InterProiView protein in InterPro
IPR022463 1-PFruKinase
IPR002173 Carboh/pur_kinase_PfkB_CS
IPR011611 PfkB_dom
IPR029056 Ribokinase-like
IPR017583 Tagatose/fructose_Pkinase
PfamiView protein in Pfam
PF00294 PfkB, 1 hit
PIRSFiPIRSF000535 1PFK/6PFK/LacC, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR03168 1-PFK, 1 hit
TIGR03828 pfkB, 1 hit
PROSITEiView protein in PROSITE
PS00583 PFKB_KINASES_1, 1 hit
PS00584 PFKB_KINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0AEW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRVATITL NPAYDLVGFC PEIERGEVNL VKTTGLHAAG KGINVAKVLK
60 70 80 90 100
DLGIDVTVGG FLGKDNQDGF QQLFSELGIA NRFQVVQGRT RINVKLTEKD
110 120 130 140 150
GEVTDFNFSG FEVTPADWER FVTDSLSWLG QFDMVCVSGS LPSGVSPEAF
160 170 180 190 200
TDWMTRLRSQ CPCIIFDSSR EALVAGLKAA PWLVKPNRRE LEIWAGRKLP
210 220 230 240 250
EMKDVIEAAH ALREQGIAHV VISLGAEGAL WVNASGEWIA KPPSVDVVST
260 270 280 290 300
VGAGDSMVGG LIYGLLMRES SEHTLRLATA VAALAVSQSN VGITDRPQLA
310
AMMARVDLQP FN
Length:312
Mass (Da):33,756
Last modified:December 20, 2005 - v1
Checksum:i067E5CF7C584FEA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53948 Genomic DNA Translation: CAA37896.1
U00007 Genomic DNA Translation: AAA60525.1
U00096 Genomic DNA Translation: AAC75229.1
AP009048 Genomic DNA Translation: BAA15977.1
PIRiB37245
RefSeqiNP_416673.1, NC_000913.3
WP_000091263.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75229; AAC75229; b2168
BAA15977; BAA15977; BAA15977
GeneIDi946676
KEGGiecj:JW2155
eco:b2168
PATRICifig|1411691.4.peg.71

Similar proteinsi

Entry informationi

Entry nameiK1PF_ECOLI
AccessioniPrimary (citable) accession number: P0AEW9
Secondary accession number(s): P23539
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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