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P0AEW5

- CPDA_ECO57

UniProt

P0AEW5 - CPDA_ECO57

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi22 – 221Metal cation 1UniRule annotation
    Metal bindingi24 – 241Metal cation 1UniRule annotation
    Binding sitei24 – 241cAMPUniRule annotation
    Metal bindingi64 – 641Metal cation 1UniRule annotation
    Metal bindingi64 – 641Metal cation 2UniRule annotation
    Binding sitei64 – 641cAMPUniRule annotation
    Metal bindingi94 – 941Metal cation 2UniRule annotation
    Metal bindingi164 – 1641Metal cation 2UniRule annotation
    Metal bindingi203 – 2031Metal cation 2UniRule annotation
    Metal bindingi205 – 2051Metal cation 1UniRule annotation
    Binding sitei205 – 2051cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi94 – 952cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-3879-MONOMER.
    ECOO157:ICC-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Synonyms:icc
    Ordered Locus Names:Z4389, ECs3920
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2752753',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000084147Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi155864.Z4389.

    Structurei

    3D structure databases

    ProteinModelPortaliP0AEW5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000238351.
    KOiK03651.
    OMAiWREIELH.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR013622. Calcineurin-like_phos_C.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0AEW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESLLTLPLA GEARVRILQI TDTHLFAQKH EALLGVNTWE SYQAVLEAIR    50
    PHQHEFDLIV ATGDLAQDQS SAAYQHFAEG IASFRAPCVW LPGNHDFQPA 100
    MYSALQDAGI SPAKRVFIGE QWQILLLDSQ VFGVPHGELS EFQLEWLERK 150
    LADAPERHTL LLLHHHPLPA GCSWLDQHSL RNAGELDTVL AKFPHVKYLL 200
    CGHIHQELDL DWNGRRLLAT PSTCVQFKPH CSNFTLDTIA PGWRTLELHA 250
    DGTLTTEVHR LADTRFQPDT ASEGY 275
    Length:275
    Mass (Da):30,938
    Last modified:December 20, 2005 - v1
    Checksum:i97696478536CFBF1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG58171.1.
    BA000007 Genomic DNA. Translation: BAB37343.1.
    PIRiG85963.
    H91118.
    RefSeqiNP_289612.1. NC_002655.2.
    NP_311947.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG58171; AAG58171; Z4389.
    BAB37343; BAB37343; BAB37343.
    GeneIDi916255.
    958507.
    KEGGiece:Z4389.
    ecs:ECs3920.
    PATRICi18357331. VBIEscCol44059_3843.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG58171.1 .
    BA000007 Genomic DNA. Translation: BAB37343.1 .
    PIRi G85963.
    H91118.
    RefSeqi NP_289612.1. NC_002655.2.
    NP_311947.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali P0AEW5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z4389.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG58171 ; AAG58171 ; Z4389 .
    BAB37343 ; BAB37343 ; BAB37343 .
    GeneIDi 916255.
    958507.
    KEGGi ece:Z4389.
    ecs:ECs3920.
    PATRICi 18357331. VBIEscCol44059_3843.

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000238351.
    KOi K03651.
    OMAi WREIELH.
    OrthoDBi EOG6QG8GQ.

    Enzyme and pathway databases

    BioCyci ECOL386585:GJFA-3879-MONOMER.
    ECOO157:ICC-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR013622. Calcineurin-like_phos_C.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    ProDomi PD587589. Calcineurin-like_phos_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiCPDA_ECO57
    AccessioniPrimary (citable) accession number: P0AEW5
    Secondary accession number(s): P36650
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3