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P0AEW5

- CPDA_ECO57

UniProt

P0AEW5 - CPDA_ECO57

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Protein
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Gene
cpdA, icc, Z4389, ECs3920
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi22 – 221Metal cation 1 By similarity
Metal bindingi24 – 241Metal cation 1 By similarity
Binding sitei24 – 241cAMP By similarity
Metal bindingi64 – 641Metal cation 1 By similarity
Metal bindingi64 – 641Metal cation 2 By similarity
Binding sitei64 – 641cAMP By similarity
Metal bindingi94 – 941Metal cation 2 By similarity
Metal bindingi164 – 1641Metal cation 2 By similarity
Metal bindingi203 – 2031Metal cation 2 By similarity
Metal bindingi205 – 2051Metal cation 1 By similarity
Binding sitei205 – 2051cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi94 – 952cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3879-MONOMER.
ECOO157:ICC-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
Short name:
3',5'-cyclic AMP phosphodiesterase
Short name:
cAMP phosphodiesterase
Gene namesi
Name:cpdA
Synonyms:icc
Ordered Locus Names:Z4389, ECs3920
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2752753',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation
PRO_0000084147Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi155864.Z4389.

Structurei

3D structure databases

ProteinModelPortaliP0AEW5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000238351.
KOiK03651.
OMAiWREIELH.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR013622. Calcineurin-like_phos_C.
IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
ProDomiPD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AEW5-1 [UniParc]FASTAAdd to Basket

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MESLLTLPLA GEARVRILQI TDTHLFAQKH EALLGVNTWE SYQAVLEAIR    50
PHQHEFDLIV ATGDLAQDQS SAAYQHFAEG IASFRAPCVW LPGNHDFQPA 100
MYSALQDAGI SPAKRVFIGE QWQILLLDSQ VFGVPHGELS EFQLEWLERK 150
LADAPERHTL LLLHHHPLPA GCSWLDQHSL RNAGELDTVL AKFPHVKYLL 200
CGHIHQELDL DWNGRRLLAT PSTCVQFKPH CSNFTLDTIA PGWRTLELHA 250
DGTLTTEVHR LADTRFQPDT ASEGY 275
Length:275
Mass (Da):30,938
Last modified:December 20, 2005 - v1
Checksum:i97696478536CFBF1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58171.1.
BA000007 Genomic DNA. Translation: BAB37343.1.
PIRiG85963.
H91118.
RefSeqiNP_289612.1. NC_002655.2.
NP_311947.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG58171; AAG58171; Z4389.
BAB37343; BAB37343; BAB37343.
GeneIDi916255.
958507.
KEGGiece:Z4389.
ecs:ECs3920.
PATRICi18357331. VBIEscCol44059_3843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58171.1 .
BA000007 Genomic DNA. Translation: BAB37343.1 .
PIRi G85963.
H91118.
RefSeqi NP_289612.1. NC_002655.2.
NP_311947.1. NC_002695.1.

3D structure databases

ProteinModelPortali P0AEW5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z4389.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG58171 ; AAG58171 ; Z4389 .
BAB37343 ; BAB37343 ; BAB37343 .
GeneIDi 916255.
958507.
KEGGi ece:Z4389.
ecs:ECs3920.
PATRICi 18357331. VBIEscCol44059_3843.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000238351.
KOi K03651.
OMAi WREIELH.
OrthoDBi EOG6QG8GQ.

Enzyme and pathway databases

BioCyci ECOL386585:GJFA-3879-MONOMER.
ECOO157:ICC-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR013622. Calcineurin-like_phos_C.
IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
ProDomi PD587589. Calcineurin-like_phos_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiCPDA_ECO57
AccessioniPrimary (citable) accession number: P0AEW5
Secondary accession number(s): P36650
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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