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Protein

Hydrogenase-4 component E

Gene

hyfE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-142.
ECOL316407:JW2470-MONOMER.

Protein family/group databases

TCDBi3.D.1.9.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase-4 component E (EC:1.-.-.-)
Gene namesi
Name:hyfE
Ordered Locus Names:b2485, JW2470
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14213. hyfE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33PeriplasmicSequence analysis
Transmembranei4 – 2421HelicalSequence analysisAdd
BLAST
Topological domaini25 – 3814CytoplasmicSequence analysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence analysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Topological domaini81 – 9212CytoplasmicSequence analysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Topological domaini114 – 1229PeriplasmicSequence analysis
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Topological domaini144 – 1507CytoplasmicSequence analysis
Transmembranei151 – 17121HelicalSequence analysisAdd
BLAST
Topological domaini172 – 1754PeriplasmicSequence analysis
Transmembranei176 – 19621HelicalSequence analysisAdd
BLAST
Topological domaini197 – 21620CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Hydrogenase-4 component EPRO_0000084115Add
BLAST

Proteomic databases

PaxDbiP0AEW1.

Interactioni

Protein-protein interaction databases

BioGridi4263214. 171 interactions.
DIPiDIP-48020N.
IntActiP0AEW1. 2 interactions.
MINTiMINT-1289177.
STRINGi511145.b2485.

Structurei

3D structure databases

ProteinModelPortaliP0AEW1.
SMRiP0AEW1. Positions 125-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107WQX. Bacteria.
COG4237. LUCA.
HOGENOMiHOG000100583.
InParanoidiP0AEW1.
KOiK12140.
OMAiGMPMVVE.

Family and domain databases

InterProiIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view]
PfamiPF00420. Oxidored_q2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AEW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGSMIVNNL AGLMMLTSLF VISVKSYRLS CGFYACQSLV LVSIFATLSC
60 70 80 90 100
LFAAEQLLIW SASAFITKVL LVPLIMTYAA RNIPQNIPEK ALFGPAMMAL
110 120 130 140 150
LAALIVLLCA FVVQPVKLPM ATGLKPALAV ALGHFLLGLL CIVSQRNILR
160 170 180 190 200
QIFGYCLMEN GSHLVLALLA WRAPELVEIG IATDAIFAVI VMVLLARKIW
210
RTHGTLDVNN LTALKG
Length:216
Mass (Da):23,361
Last modified:December 20, 2005 - v1
Checksum:i141A76B9961D8F4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88567.1.
U00096 Genomic DNA. Translation: AAC75538.1.
AP009048 Genomic DNA. Translation: BAA16373.1.
PIRiD65024.
RefSeqiNP_416980.1. NC_000913.3.
WP_000147987.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75538; AAC75538; b2485.
BAA16373; BAA16373; BAA16373.
GeneIDi945298.
KEGGiecj:JW2470.
eco:b2485.
PATRICi32120357. VBIEscCol129921_2581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88567.1.
U00096 Genomic DNA. Translation: AAC75538.1.
AP009048 Genomic DNA. Translation: BAA16373.1.
PIRiD65024.
RefSeqiNP_416980.1. NC_000913.3.
WP_000147987.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AEW1.
SMRiP0AEW1. Positions 125-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263214. 171 interactions.
DIPiDIP-48020N.
IntActiP0AEW1. 2 interactions.
MINTiMINT-1289177.
STRINGi511145.b2485.

Protein family/group databases

TCDBi3.D.1.9.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiP0AEW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75538; AAC75538; b2485.
BAA16373; BAA16373; BAA16373.
GeneIDi945298.
KEGGiecj:JW2470.
eco:b2485.
PATRICi32120357. VBIEscCol129921_2581.

Organism-specific databases

EchoBASEiEB3965.
EcoGeneiEG14213. hyfE.

Phylogenomic databases

eggNOGiENOG4107WQX. Bacteria.
COG4237. LUCA.
HOGENOMiHOG000100583.
InParanoidiP0AEW1.
KOiK12140.
OMAiGMPMVVE.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-142.
ECOL316407:JW2470-MONOMER.

Miscellaneous databases

PROiP0AEW1.

Family and domain databases

InterProiIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view]
PfamiPF00420. Oxidored_q2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYFE_ECOLI
AccessioniPrimary (citable) accession number: P0AEW1
Secondary accession number(s): P77524
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.