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Protein

Hydrogenase 3 maturation protease

Gene

hycI

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease involved in the C-terminal processing of HycE, the large subunit of hydrogenase 3.By similarity

Catalytic activityi

This enzyme specifically removes a 32-amino acid peptide from the C-terminus of the precursor of the large subunit of E.coli hydrogenase 3 by cleavage at the C-terminal side of Arg-537.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi16NickelBy similarity1
Metal bindingi62NickelBy similarity1
Metal bindingi90NickelBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease
LigandMetal-binding, Nickel

Protein family/group databases

MEROPSiA31.003

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase 3 maturation protease (EC:3.4.23.51By similarity)
Alternative name(s):
HycI protease
Gene namesi
Name:hycI
Ordered Locus Names:Z4025, ECs3573
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002019452 – 156Hydrogenase 3 maturation proteaseAdd BLAST155

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi155864.Z4025

Structurei

3D structure databases

ProteinModelPortaliP0AEW0
SMRiP0AEW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A31 family.Curated

Phylogenomic databases

eggNOGiENOG4108MG9 Bacteria
COG0680 LUCA
HOGENOMiHOG000278720
KOiK08315
OMAiEMCAANP

Family and domain databases

CDDicd06067 H2MP_MemB-H2evol, 1 hit
Gene3Di3.40.50.1450, 1 hit
InterProiView protein in InterPro
IPR004420 Pept_A31_hyd_mat_HycI
IPR023430 Pept_HybD-like_dom_sf
IPR000671 Peptidase_A31
PANTHERiPTHR30302 PTHR30302, 1 hit
PfamiView protein in Pfam
PF01750 HycI, 1 hit
PRINTSiPR00446 HYDRGNUPTAKE
SUPFAMiSSF53163 SSF53163, 1 hit
TIGRFAMsiTIGR00142 hycI, 1 hit
TIGR00072 hydrog_prot, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AEW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDVLLCVGN SMMGDDGAGP LLAEKCAAAP KGNWVVIDGG SAPENDIVAI
60 70 80 90 100
RELRPTRLLI VDATDMGLNP GEIRIIDPDD IAEMFMMTTH NMPLNYLIDQ
110 120 130 140 150
LKEDIGEVIF LGIQPDIVGF YYPMTQPIKD AVETVYQRLE GWEGNGGFAQ

LAVEEE
Length:156
Mass (Da):17,057
Last modified:January 23, 2007 - v2
Checksum:iCCE90535AFC0F30D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG57824.1
BA000007 Genomic DNA Translation: BAB36996.1
PIRiD85920
E91075
RefSeqiNP_311600.1, NC_002695.1
WP_000132961.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG57824; AAG57824; Z4025
BAB36996; BAB36996; BAB36996
GeneIDi914705
KEGGiece:Z4025
ecs:ECs3573
PATRICifig|386585.9.peg.3734

Similar proteinsi

Entry informationi

Entry nameiHYCI_ECO57
AccessioniPrimary (citable) accession number: P0AEW0
Secondary accession number(s): Q57451
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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