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Protein

Formate hydrogenlyase regulatory protein HycA

Gene

hycA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory protein for the formate hydrogenlyase system. Could act by directly interacting with FhlA or by preventing the binding of FhlA to the upstream activatory sequence.1 Publication

GO - Biological processi

  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG10474-MONOMER.
ECOL316407:JW2695-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate hydrogenlyase regulatory protein HycA
Gene namesi
Name:hycA
Synonyms:hevA
Ordered Locus Names:b2725, JW2695
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10474. hycA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Formate hydrogenlyase regulatory protein HycAPRO_0000084100Add
BLAST

Proteomic databases

PaxDbiP0AEV4.

Interactioni

Protein-protein interaction databases

BioGridi4262102. 11 interactions.
IntActiP0AEV4. 1 interaction.
STRINGi511145.b2725.

Structurei

3D structure databases

ProteinModelPortaliP0AEV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4108VRC. Bacteria.
ENOG4111JXQ. LUCA.
HOGENOMiHOG000124058.
KOiK15833.
OMAiHAMSCAA.

Family and domain databases

InterProiIPR021285. Tscrpt_reg_HycA.
[Graphical view]
PfamiPF11046. HycA_repressor. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AEV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIWEISEKA DYIAQRHRRL QDQWHIYCNS LVQGITLSKA RLHHAMSCAP
60 70 80 90 100
DKELCFVLFE HFRIYVTLAD GFNSHTIEYY VETKDGEDKQ RIAQAQLSID
110 120 130 140 150
GMIDGKVNIR DREQVLEHYL EKIAGVYDSL YTAIENNVPV NLSQLVKGQS

PAA
Length:153
Mass (Da):17,627
Last modified:December 20, 2005 - v1
Checksum:iCB61EC856450A0AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17506 Genomic DNA. Translation: CAA35546.1.
U29579 Genomic DNA. Translation: AAA69235.1.
U00096 Genomic DNA. Translation: AAC75767.1.
AP009048 Genomic DNA. Translation: BAE76802.1.
PIRiS08619.
RefSeqiNP_417205.1. NC_000913.3.
WP_000158056.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75767; AAC75767; b2725.
BAE76802; BAE76802; BAE76802.
GeneIDi947193.
KEGGiecj:JW2695.
eco:b2725.
PATRICi32120850. VBIEscCol129921_2817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17506 Genomic DNA. Translation: CAA35546.1.
U29579 Genomic DNA. Translation: AAA69235.1.
U00096 Genomic DNA. Translation: AAC75767.1.
AP009048 Genomic DNA. Translation: BAE76802.1.
PIRiS08619.
RefSeqiNP_417205.1. NC_000913.3.
WP_000158056.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AEV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262102. 11 interactions.
IntActiP0AEV4. 1 interaction.
STRINGi511145.b2725.

Proteomic databases

PaxDbiP0AEV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75767; AAC75767; b2725.
BAE76802; BAE76802; BAE76802.
GeneIDi947193.
KEGGiecj:JW2695.
eco:b2725.
PATRICi32120850. VBIEscCol129921_2817.

Organism-specific databases

EchoBASEiEB0469.
EcoGeneiEG10474. hycA.

Phylogenomic databases

eggNOGiENOG4108VRC. Bacteria.
ENOG4111JXQ. LUCA.
HOGENOMiHOG000124058.
KOiK15833.
OMAiHAMSCAA.

Enzyme and pathway databases

BioCyciEcoCyc:EG10474-MONOMER.
ECOL316407:JW2695-MONOMER.

Miscellaneous databases

PROiP0AEV4.

Family and domain databases

InterProiIPR021285. Tscrpt_reg_HycA.
[Graphical view]
PfamiPF11046. HycA_repressor. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYCA_ECOLI
AccessioniPrimary (citable) accession number: P0AEV4
Secondary accession number(s): P16427, Q2MAA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.