P0AEV1 (HNR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein hnr

Gene names

Name:	hnr
Synonyms:	ychL
Ordered Locus Names:	b1235, JW1223

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 response regulatory domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Two-component regulatory system
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW two-component response regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 337

337

Protein hnr

PRO_0000081388

Regions

Domain

9 – 123

115

Response regulatory

Amino acid modifications

Modified residue

58

1

4-aspartylphosphate By similarity

Secondary structure

1

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337

Helix Strand Turn

Details...

Beta strand

9 – 13

5

Helix

17 – 29

13

Beta strand

33 – 37

5

Helix

42 – 46

5

Beta strand

53 – 57

5

Helix

68 – 75

8

Beta strand

82 – 86

5

Helix

91 – 99

9

Beta strand

104 – 108

5

Helix

115 – 124

10

Sequences

	Sequence		Length	Mass (Da)
	P0AEV1 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: AB962EF94BC7B470	FASTA	337	37,302
	10 20 30 40 50 60 MTQPLVGKQI LIVEDEQVFR SLLDSWFSSL GATTVLAADG VDALELLGGF TPDLMICDIA 70 80 90 100 110 120 MPRMNGLKLL EHIRNRGDQT PVLVISATEN MADIAKALRL GVEDVLLKPV KDLNRLREMV 130 140 150 160 170 180 FACLYPSMFN SRVEEEERLF RDWDAMVDNP AAAAKLLQEL QPPVQQVISH CRVNYRQLVA 190 200 210 220 230 240 ADKPGLVLDI AALSENDLAF YCLDVTRAGH NGVLAALLLR ALFNGLLQEQ LAHQNQRLPE 250 260 270 280 290 300 LGALLKQVNH LLRQANLPGQ FPLLVGYYHR ELKNLILVSA GLNATLNTGE HQVQISNGVP 310 320 330 LGTLGNAYLN QLSQRCDAWQ CQIWGTGGRL RLMLSAE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Contreras A. Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"Organization and functions of genes in the upstream region of tyrT of Escherichia coli: phenotypes of mutants with partial deletion of a new gene (tgs)." Boesl M., Kersten H. J. Bacteriol. 176:221-231(1994) [PubMed: 8282700] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[3]	"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T. DNA Res. 3:137-155(1996) [PubMed: 8905232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[5]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X66003 Genomic DNA. Translation: CAA46802.1.
M64675 Unassigned DNA. No translation available.
U00096 Genomic DNA. Translation: AAC74317.1.
AP009048 Genomic DNA. Translation: BAA36103.1.

PIR

A36871.

RefSeq

NP_415751.1. NC_000913.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3EOD	X-ray	1.75	A	1-130	[»]

ProteinModelPortal

P0AEV1.

SMR

P0AEV1. Positions 3-337.

ModBase

Search...

Protein-protein interaction databases

IntAct

P0AEV1. 1 interaction.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBESCT00000002730; EBESCP00000002730; EBESCG00000002226.
EBESCT00000002731; EBESCP00000002731; EBESCG00000002226.
EBESCT00000016710; EBESCP00000016001; EBESCG00000015769.

GeneID

945855.

GenomeReviews

Gene locus JW1223 in contig AP009048_GR.
Gene locus b1235 in contig U00096_GR.

KEGG

ecj:JW1223.
eco:b1235.

PATRIC

32117726. VBIEscCol129921_1283.

Organism-specific databases

EchoBASE

EB2042.

EcoGene

EG12121. hnr.

Phylogenomic databases

eggNOG

COG0784.

GeneTree

EBGT00050000008648.

HOGENOM

HBG416104.

OMA

NQISQRC.

PhylomeDB

P0AEV1.

ProtClustDB

PRK10693.

Enzyme and pathway databases

BioCyc

EcoCyc:EG12121-MONOMER.

Gene expression databases

Genevestigator

P0AEV1.

Family and domain databases

InterPro

IPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]

KO

K02485.

Pfam

PF00072. Response_reg. 1 hit.
[Graphical view]

SMART

SM00448. REC. 1 hit.
[Graphical view]

SUPFAM

SSF52172. CheY_like. 1 hit.

PROSITE

PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

HNR_ECOLI

Accession

Primary (citable) accession number: P0AEV1
Secondary accession number(s): P37055

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program