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Protein

Histidine transport system permease protein HisM

Gene

hisM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:HISM-MONOMER

Protein family/group databases

TCDBi3.A.1.3.29 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine transport system permease protein HisM
Gene namesi
Name:hisM
Ordered Locus Names:b2307, JW2304
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10007 hisM

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26PeriplasmicSequence analysisAdd BLAST26
Transmembranei27 – 47HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini48 – 58CytoplasmicSequence analysisAdd BLAST11
Transmembranei59 – 79HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini80 – 104PeriplasmicSequence analysisAdd BLAST25
Transmembranei105 – 125HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini126 – 157CytoplasmicSequence analysisAdd BLAST32
Transmembranei158 – 178HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini179 – 200PeriplasmicSequence analysisAdd BLAST22
Transmembranei201 – 221HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini222 – 238CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: InterPro
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000600441 – 238Histidine transport system permease protein HisMAdd BLAST238

Proteomic databases

PaxDbiP0AEU3
PRIDEiP0AEU3

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ or ArgT).By similarity

Protein-protein interaction databases

BioGridi4260522, 5 interactors
STRINGi316385.ECDH10B_2469

Structurei

3D structure databases

ProteinModelPortaliP0AEU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 221ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST199

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4106YG3 Bacteria
COG4160 LUCA
HOGENOMiHOG000267552
InParanoidiP0AEU3
KOiK10015
OMAiKVRYAEF
PhylomeDBiP0AEU3

Family and domain databases

CDDicd06261 TM_PBP2, 1 hit
Gene3Di1.10.3720.10, 1 hit
InterProiView protein in InterPro
IPR010065 AA_ABC_transptr_permease_3TM
IPR000515 MetI-like
IPR035906 MetI-like_sf
PfamiView protein in Pfam
PF00528 BPD_transp_1, 1 hit
SUPFAMiSSF161098 SSF161098, 1 hit
TIGRFAMsiTIGR01726 HEQRo_perm_3TM, 1 hit
PROSITEiView protein in PROSITE
PS50928 ABC_TM1, 1 hit

Sequencei

Sequence statusi: Complete.

P0AEU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEILHEYWK PLLWTDGYRF TGVAITLWLL ILSVVIGGVL ALFLAIGRVS
60 70 80 90 100
SNKYIQFPIW LFTYIFRGTP LYVQLLVFYS GMYTLEIVKG TEFLNAFFRS
110 120 130 140 150
GLNCTVLALT LNTCAYTTEI FAGAIRSVPH GEIEAARAYG FSTFKMYRCI
160 170 180 190 200
ILPSALRIAL PAYSNEVILM LHSTALAFTA TVPDLLKIAR DINAATYQPF
210 220 230
TAFGIAAVLY LIISYVLISL FRRAEKRWLQ HVKPSSTH
Length:238
Mass (Da):26,870
Last modified:December 20, 2005 - v1
Checksum:i0307840A94836348
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75367.1
AP009048 Genomic DNA Translation: BAA16153.1
U47027 Genomic DNA Translation: AAA85771.1
Y00455 Genomic DNA Translation: CAA68510.1
PIRiA65003 B27835
RefSeqiNP_416810.1, NC_000913.3
WP_000569958.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75367; AAC75367; b2307
BAA16153; BAA16153; BAA16153
GeneIDi946790
KEGGiecj:JW2304
eco:b2307
PATRICifig|1411691.4.peg.4427

Similar proteinsi

Entry informationi

Entry nameiHISM_ECOLI
AccessioniPrimary (citable) accession number: P0AEU3
Secondary accession number(s): P20091, P76936
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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