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Protein

Histidine transport system permease protein HisM

Gene

hisM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:HISM-MONOMER.
ECOL316407:JW2304-MONOMER.
MetaCyc:HISM-MONOMER.

Protein family/group databases

TCDBi3.A.1.3.29. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine transport system permease protein HisM
Gene namesi
Name:hisM
Ordered Locus Names:b2307, JW2304
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10007. hisM.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626PeriplasmicSequence analysisAdd
BLAST
Transmembranei27 – 4721HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini48 – 5811CytoplasmicSequence analysisAdd
BLAST
Transmembranei59 – 7921HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini80 – 10425PeriplasmicSequence analysisAdd
BLAST
Transmembranei105 – 12521HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini126 – 15732CytoplasmicSequence analysisAdd
BLAST
Transmembranei158 – 17821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini179 – 20022PeriplasmicSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini222 – 23817CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Histidine transport system permease protein HisMPRO_0000060044Add
BLAST

Proteomic databases

PaxDbiP0AEU3.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ or ArgT).By similarity

Protein-protein interaction databases

BioGridi4260522. 5 interactions.
STRINGi511145.b2307.

Structurei

3D structure databases

ProteinModelPortaliP0AEU3.
SMRiP0AEU3. Positions 21-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 221199ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4106YG3. Bacteria.
COG4160. LUCA.
HOGENOMiHOG000267552.
InParanoidiP0AEU3.
KOiK10015.
OMAiRFSFPVW.
OrthoDBiEOG6MM1R5.
PhylomeDBiP0AEU3.

Family and domain databases

Gene3Di1.10.3720.10. 1 hit.
InterProiIPR010065. AA_ABC_transptr_permease_3TM.
IPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01726. HEQRo_perm_3TM. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AEU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEILHEYWK PLLWTDGYRF TGVAITLWLL ILSVVIGGVL ALFLAIGRVS
60 70 80 90 100
SNKYIQFPIW LFTYIFRGTP LYVQLLVFYS GMYTLEIVKG TEFLNAFFRS
110 120 130 140 150
GLNCTVLALT LNTCAYTTEI FAGAIRSVPH GEIEAARAYG FSTFKMYRCI
160 170 180 190 200
ILPSALRIAL PAYSNEVILM LHSTALAFTA TVPDLLKIAR DINAATYQPF
210 220 230
TAFGIAAVLY LIISYVLISL FRRAEKRWLQ HVKPSSTH
Length:238
Mass (Da):26,870
Last modified:December 20, 2005 - v1
Checksum:i0307840A94836348
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75367.1.
AP009048 Genomic DNA. Translation: BAA16153.1.
U47027 Genomic DNA. Translation: AAA85771.1.
Y00455 Genomic DNA. Translation: CAA68510.1.
PIRiA65003. B27835.
RefSeqiNP_416810.1. NC_000913.3.
WP_000569958.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75367; AAC75367; b2307.
BAA16153; BAA16153; BAA16153.
GeneIDi946790.
KEGGiecj:JW2304.
eco:b2307.
PATRICi32119985. VBIEscCol129921_2402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75367.1.
AP009048 Genomic DNA. Translation: BAA16153.1.
U47027 Genomic DNA. Translation: AAA85771.1.
Y00455 Genomic DNA. Translation: CAA68510.1.
PIRiA65003. B27835.
RefSeqiNP_416810.1. NC_000913.3.
WP_000569958.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AEU3.
SMRiP0AEU3. Positions 21-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260522. 5 interactions.
STRINGi511145.b2307.

Protein family/group databases

TCDBi3.A.1.3.29. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0AEU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75367; AAC75367; b2307.
BAA16153; BAA16153; BAA16153.
GeneIDi946790.
KEGGiecj:JW2304.
eco:b2307.
PATRICi32119985. VBIEscCol129921_2402.

Organism-specific databases

EchoBASEiEB0007.
EcoGeneiEG10007. hisM.

Phylogenomic databases

eggNOGiENOG4106YG3. Bacteria.
COG4160. LUCA.
HOGENOMiHOG000267552.
InParanoidiP0AEU3.
KOiK10015.
OMAiRFSFPVW.
OrthoDBiEOG6MM1R5.
PhylomeDBiP0AEU3.

Enzyme and pathway databases

BioCyciEcoCyc:HISM-MONOMER.
ECOL316407:JW2304-MONOMER.
MetaCyc:HISM-MONOMER.

Miscellaneous databases

PROiP0AEU3.

Family and domain databases

Gene3Di1.10.3720.10. 1 hit.
InterProiIPR010065. AA_ABC_transptr_permease_3TM.
IPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01726. HEQRo_perm_3TM. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Joshi A., Ames G.F.-L.
    Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-93.
    Strain: K12.
  5. "Sequence of the complete P protein gene and part of the M protein gene from the histidine transport operon of Escherichia coli compared to that of Salmonella typhimurium."
    Kraft R., Leinwand L.A.
    Nucleic Acids Res. 15:8568-8568(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 92-238.
    Strain: K12.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiHISM_ECOLI
AccessioniPrimary (citable) accession number: P0AEU3
Secondary accession number(s): P20091, P76936
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: January 20, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.