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Protein

Glutamate/aspartate import permease protein GltK

Gene

gltK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for the translocation of the substrate across the membrane.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:GLTK-MONOMER.
ECOL316407:JW0648-MONOMER.
MetaCyc:GLTK-MONOMER.

Protein family/group databases

TCDBi3.A.1.3.4. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate/aspartate import permease protein GltKCurated
Gene namesi
Name:gltK
Ordered Locus Names:b0653, JW0648
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12662. gltK.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919PeriplasmicCuratedAdd
BLAST
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST
Topological domaini41 – 6727CytoplasmicCuratedAdd
BLAST
Transmembranei68 – 8821HelicalSequence analysisAdd
BLAST
Topological domaini89 – 946PeriplasmicCurated
Transmembranei95 – 11218HelicalSequence analysisAdd
BLAST
Topological domaini113 – 15442CytoplasmicCuratedAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Topological domaini176 – 19621PeriplasmicCuratedAdd
BLAST
Transmembranei197 – 21721HelicalSequence analysisAdd
BLAST
Topological domaini218 – 2247Cytoplasmic1 Publication

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: InterPro
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Glutamate/aspartate import permease protein GltKPRO_0000060037Add
BLAST

Proteomic databases

PaxDbiP0AER5.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (GltL), two transmembrane proteins (GltJ and GltK) and a solute-binding protein (GltI).1 Publication

Protein-protein interaction databases

BioGridi4259913. 8 interactions.
STRINGi511145.b0653.

Structurei

3D structure databases

ProteinModelPortaliP0AER5.
SMRiP0AER5. Positions 5-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 216197ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DRP. Bacteria.
COG0765. LUCA.
HOGENOMiHOG000267552.
InParanoidiP0AER5.
KOiK10002.
OMAiISWFAKL.
OrthoDBiEOG6MM1R5.
PhylomeDBiP0AER5.

Family and domain databases

Gene3Di1.10.3720.10. 1 hit.
InterProiIPR010065. AA_ABC_transptr_permease_3TM.
IPR030205. GltK/AatM.
IPR000515. MetI-like.
[Graphical view]
PANTHERiPTHR30614:SF1. PTHR30614:SF1. 1 hit.
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01726. HEQRo_perm_3TM. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AER5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYEFDWSSIV PSLPYLLDGL VITLKITVTA VVIGILWGTM LAVMRLSSFA
60 70 80 90 100
PVAWFAKAYV NVFRSIPLVM VLLWFYLIVP GFLQNVLGLS PKNDIRLISA
110 120 130 140 150
MVAFSMFEAA YYSEIIRAGI QSISRGQSSA ALALGMTHWQ SMKLIILPQA
160 170 180 190 200
FRAMVPLLLT QGIVLFQDTS LVYVLSLADF FRTASTIGER DGTQVEMILF
210 220
AGFVYFVISL SASLLVSYLK RRTA
Length:224
Mass (Da):24,915
Last modified:December 20, 2005 - v1
Checksum:i01BCB38D387807B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10981 Genomic DNA. Translation: AAA60981.1.
U82598 Genomic DNA. Translation: AAB40854.1.
U00096 Genomic DNA. Translation: AAC73754.1.
AP009048 Genomic DNA. Translation: BAA35305.1.
PIRiC64800.
RefSeqiNP_415186.1. NC_000913.3.
WP_000272824.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73754; AAC73754; b0653.
BAA35305; BAA35305; BAA35305.
GeneIDi947354.
KEGGiecj:JW0648.
eco:b0653.
PATRICi32116489. VBIEscCol129921_0684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10981 Genomic DNA. Translation: AAA60981.1.
U82598 Genomic DNA. Translation: AAB40854.1.
U00096 Genomic DNA. Translation: AAC73754.1.
AP009048 Genomic DNA. Translation: BAA35305.1.
PIRiC64800.
RefSeqiNP_415186.1. NC_000913.3.
WP_000272824.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AER5.
SMRiP0AER5. Positions 5-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259913. 8 interactions.
STRINGi511145.b0653.

Protein family/group databases

TCDBi3.A.1.3.4. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0AER5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73754; AAC73754; b0653.
BAA35305; BAA35305; BAA35305.
GeneIDi947354.
KEGGiecj:JW0648.
eco:b0653.
PATRICi32116489. VBIEscCol129921_0684.

Organism-specific databases

EchoBASEiEB2528.
EcoGeneiEG12662. gltK.

Phylogenomic databases

eggNOGiENOG4105DRP. Bacteria.
COG0765. LUCA.
HOGENOMiHOG000267552.
InParanoidiP0AER5.
KOiK10002.
OMAiISWFAKL.
OrthoDBiEOG6MM1R5.
PhylomeDBiP0AER5.

Enzyme and pathway databases

BioCyciEcoCyc:GLTK-MONOMER.
ECOL316407:JW0648-MONOMER.
MetaCyc:GLTK-MONOMER.

Miscellaneous databases

PROiP0AER5.

Family and domain databases

Gene3Di1.10.3720.10. 1 hit.
InterProiIPR010065. AA_ABC_transptr_permease_3TM.
IPR030205. GltK/AatM.
IPR000515. MetI-like.
[Graphical view]
PANTHERiPTHR30614:SF1. PTHR30614:SF1. 1 hit.
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01726. HEQRo_perm_3TM. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and characterisation of three genes of a glutamate-aspartate binding protein-dependent transport system of Escherichia coli K12."
    Lum D., Wallace B.J.
    Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / BK9MDG.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION.
    Strain: K12 / MG1655 / ATCC 47076.
  7. "The Escherichia coli ATP-binding cassette (ABC) proteins."
    Linton K.J., Higgins C.F.
    Mol. Microbiol. 28:5-13(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiGLTK_ECOLI
AccessioniPrimary (citable) accession number: P0AER5
Secondary accession number(s): P41075
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.