Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate/aspartate import permease protein GltK

Gene

gltK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for the translocation of the substrate across the membrane.1 Publication

GO - Molecular functioni

GO - Biological processi

  • toxin transport Source: EcoCyc

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:GLTK-MONOMER
MetaCyc:GLTK-MONOMER

Protein family/group databases

TCDBi3.A.1.3.4 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate/aspartate import permease protein GltKCurated
Gene namesi
Name:gltK
Ordered Locus Names:b0653, JW0648
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12662 gltK

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19PeriplasmicCuratedAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 67CytoplasmicCuratedAdd BLAST27
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 94PeriplasmicCurated6
Transmembranei95 – 112HelicalSequence analysisAdd BLAST18
Topological domaini113 – 154CytoplasmicCuratedAdd BLAST42
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 196PeriplasmicCuratedAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 224Cytoplasmic1 Publication7

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: InterPro
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000600371 – 224Glutamate/aspartate import permease protein GltKAdd BLAST224

Proteomic databases

PaxDbiP0AER5
PRIDEiP0AER5

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (GltL), two transmembrane proteins (GltJ and GltK) and a solute-binding protein (GltI).1 Publication

Protein-protein interaction databases

BioGridi4259913, 8 interactors
STRINGi316385.ECDH10B_0722

Structurei

3D structure databases

ProteinModelPortaliP0AER5
SMRiP0AER5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 216ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST197

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DRP Bacteria
COG0765 LUCA
HOGENOMiHOG000267552
InParanoidiP0AER5
KOiK10002
OMAiVFESAMI
PhylomeDBiP0AER5

Family and domain databases

CDDicd06261 TM_PBP2, 1 hit
Gene3Di1.10.3720.10, 1 hit
InterProiView protein in InterPro
IPR010065 AA_ABC_transptr_permease_3TM
IPR030205 GltK/AatM
IPR000515 MetI-like
IPR035906 MetI-like_sf
PANTHERiPTHR30614:SF1 PTHR30614:SF1, 1 hit
PfamiView protein in Pfam
PF00528 BPD_transp_1, 1 hit
SUPFAMiSSF161098 SSF161098, 1 hit
TIGRFAMsiTIGR01726 HEQRo_perm_3TM, 1 hit
PROSITEiView protein in PROSITE
PS50928 ABC_TM1, 1 hit

Sequencei

Sequence statusi: Complete.

P0AER5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYEFDWSSIV PSLPYLLDGL VITLKITVTA VVIGILWGTM LAVMRLSSFA
60 70 80 90 100
PVAWFAKAYV NVFRSIPLVM VLLWFYLIVP GFLQNVLGLS PKNDIRLISA
110 120 130 140 150
MVAFSMFEAA YYSEIIRAGI QSISRGQSSA ALALGMTHWQ SMKLIILPQA
160 170 180 190 200
FRAMVPLLLT QGIVLFQDTS LVYVLSLADF FRTASTIGER DGTQVEMILF
210 220
AGFVYFVISL SASLLVSYLK RRTA
Length:224
Mass (Da):24,915
Last modified:December 20, 2005 - v1
Checksum:i01BCB38D387807B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10981 Genomic DNA Translation: AAA60981.1
U82598 Genomic DNA Translation: AAB40854.1
U00096 Genomic DNA Translation: AAC73754.1
AP009048 Genomic DNA Translation: BAA35305.1
PIRiC64800
RefSeqiNP_415186.1, NC_000913.3
WP_000272824.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73754; AAC73754; b0653
BAA35305; BAA35305; BAA35305
GeneIDi947354
KEGGiecj:JW0648
eco:b0653
PATRICifig|1411691.4.peg.1615

Similar proteinsi

Entry informationi

Entry nameiGLTK_ECOLI
AccessioniPrimary (citable) accession number: P0AER5
Secondary accession number(s): P41075
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health