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Protein

Glutamate/aspartate import permease protein GltJ

Gene

gltJ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for the translocation of the substrate across the membrane.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:GLTJ-MONOMER.
ECOL316407:JW0649-MONOMER.
MetaCyc:GLTJ-MONOMER.

Protein family/group databases

TCDBi3.A.1.3.4. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate/aspartate import permease protein GltJCurated
Gene namesi
Name:gltJ
Ordered Locus Names:b0654, JW0649
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12661. gltJ.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence analysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence analysisAdd
BLAST
Transmembranei179 – 19618HelicalSequence analysisAdd
BLAST
Transmembranei212 – 23221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: InterPro
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Glutamate/aspartate import permease protein GltJPRO_0000060035Add
BLAST

Proteomic databases

PaxDbiP0AER3.
PRIDEiP0AER3.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (GltL), two transmembrane proteins (GltJ and GltK) and a solute-binding protein (GltI).1 Publication

Protein-protein interaction databases

BioGridi4259914. 3 interactions.
DIPiDIP-35965N.
IntActiP0AER3. 6 interactions.
MINTiMINT-1264109.
STRINGi511145.b0654.

Structurei

3D structure databases

ProteinModelPortaliP0AER3.
SMRiP0AER3. Positions 27-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 230202ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EAD. Bacteria.
COG0765. LUCA.
HOGENOMiHOG000267552.
InParanoidiP0AER3.
KOiK10003.
OMAiIMLVMNL.
PhylomeDBiP0AER3.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR010065. AA_ABC_transptr_permease_3TM.
IPR030202. GltJ/AatQ.
IPR000515. MetI-like.
[Graphical view]
PANTHERiPTHR30085:SF4. PTHR30085:SF4. 1 hit.
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01726. HEQRo_perm_3TM. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AER3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIDWNWGIF LQQAPFGNTT YLGWIWSGFQ VTIALSICAW IIAFLVGSFF
60 70 80 90 100
GILRTVPNRF LSGLGTLYVE LFRNVPLIVQ FFTWYLVIPE LLPEKIGMWF
110 120 130 140 150
KAELDPNIQF FLSSMLCLGL FTAARVCEQV RAAIQSLPRG QKNAALAMGL
160 170 180 190 200
TLPQAYRYVL LPNAYRVIVP PMTSEMMNLV KNSAIASTIG LVDMAAQAGK
210 220 230 240
LLDYSAHAWE SFTAITLAYV LINAFIMLVM TLVERKVRLP GNMGGK
Length:246
Mass (Da):27,503
Last modified:December 20, 2005 - v1
Checksum:iE9E5CAF26BD252B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10981 Genomic DNA. Translation: AAA60980.1.
U82598 Genomic DNA. Translation: AAB40855.1.
U00096 Genomic DNA. Translation: AAC73755.1.
AP009048 Genomic DNA. Translation: BAA35306.1.
PIRiD64800.
RefSeqiNP_415187.1. NC_000913.3.
WP_000020941.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73755; AAC73755; b0654.
BAA35306; BAA35306; BAA35306.
GeneIDi945443.
KEGGiecj:JW0649.
eco:b0654.
PATRICi32116491. VBIEscCol129921_0685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10981 Genomic DNA. Translation: AAA60980.1.
U82598 Genomic DNA. Translation: AAB40855.1.
U00096 Genomic DNA. Translation: AAC73755.1.
AP009048 Genomic DNA. Translation: BAA35306.1.
PIRiD64800.
RefSeqiNP_415187.1. NC_000913.3.
WP_000020941.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AER3.
SMRiP0AER3. Positions 27-238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259914. 3 interactions.
DIPiDIP-35965N.
IntActiP0AER3. 6 interactions.
MINTiMINT-1264109.
STRINGi511145.b0654.

Protein family/group databases

TCDBi3.A.1.3.4. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0AER3.
PRIDEiP0AER3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73755; AAC73755; b0654.
BAA35306; BAA35306; BAA35306.
GeneIDi945443.
KEGGiecj:JW0649.
eco:b0654.
PATRICi32116491. VBIEscCol129921_0685.

Organism-specific databases

EchoBASEiEB2527.
EcoGeneiEG12661. gltJ.

Phylogenomic databases

eggNOGiENOG4105EAD. Bacteria.
COG0765. LUCA.
HOGENOMiHOG000267552.
InParanoidiP0AER3.
KOiK10003.
OMAiIMLVMNL.
PhylomeDBiP0AER3.

Enzyme and pathway databases

BioCyciEcoCyc:GLTJ-MONOMER.
ECOL316407:JW0649-MONOMER.
MetaCyc:GLTJ-MONOMER.

Miscellaneous databases

PROiP0AER3.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR010065. AA_ABC_transptr_permease_3TM.
IPR030202. GltJ/AatQ.
IPR000515. MetI-like.
[Graphical view]
PANTHERiPTHR30085:SF4. PTHR30085:SF4. 1 hit.
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01726. HEQRo_perm_3TM. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLTJ_ECOLI
AccessioniPrimary (citable) accession number: P0AER3
Secondary accession number(s): P41074
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.