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Protein

Glycolate oxidase subunit GlcD

Gene

glcD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cofactori

FADCurated

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: InterPro
  • glycolate dehydrogenase activity Source: EcoCyc
  • glycolate oxidase activity Source: InterPro

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • glycolate catabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciEcoCyc:G7545-MONOMER.
ECOL316407:JW2946-MONOMER.
MetaCyc:G7545-MONOMER.
RETL1328306-WGS:GSTH-5078-MONOMER.
RETL1328306-WGS:GSTH-817-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycolate oxidase subunit GlcD
Gene namesi
Name:glcD
Synonyms:gox, yghM
Ordered Locus Names:b2979, JW2946
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12997. glcD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Glycolate oxidase subunit GlcDPRO_0000128181Add
BLAST

Proteomic databases

PaxDbiP0AEP9.

Interactioni

Protein-protein interaction databases

BioGridi4262368. 16 interactions.
IntActiP0AEP9. 3 interactions.
STRINGi511145.b2979.

Structurei

3D structure databases

ProteinModelPortaliP0AEP9.
SMRiP0AEP9. Positions 40-470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 230179FAD-binding PCMH-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CQB. Bacteria.
COG0277. LUCA.
HOGENOMiHOG000230998.
InParanoidiP0AEP9.
KOiK00104.
OMAiTPRTCGE.
OrthoDBiEOG6RZB40.
PhylomeDBiP0AEP9.

Family and domain databases

Gene3Di1.10.45.10. 1 hit.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR016164. FAD-linked_Oxase-like_C.
IPR004113. FAD-linked_oxidase_C.
IPR004490. GlcD.
IPR006094. Oxid_FAD_bind_N.
IPR016171. Vanillyl_alc_oxidase_C-sub2.
[Graphical view]
PfamiPF02913. FAD-oxidase_C. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
SUPFAMiSSF55103. SSF55103. 1 hit.
SSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR00387. glcD. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AEP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILYEERLD GALPDVDRTS VLMALREHVP GLEILHTDEE IIPYECDGLS
60 70 80 90 100
AYRTRPLLVV LPKQMEQVTA ILAVCHRLRV PVVTRGAGTG LSGGALPLEK
110 120 130 140 150
GVLLVMARFK EILDINPVGR RARVQPGVRN LAISQAVAPH NLYYAPDPSS
160 170 180 190 200
QIACSIGGNV AENAGGVHCL KYGLTVHNLL KIEVQTLDGE ALTLGSDALD
210 220 230 240 250
SPGFDLLALF TGSEGMLGVT TEVTVKLLPK PPVARVLLAS FDSVEKAGLA
260 270 280 290 300
VGDIIANGII PGGLEMMDNL SIRAAEDFIH AGYPVDAEAI LLCELDGVES
310 320 330 340 350
DVQEDCERVN DILLKAGATD VRLAQDEAER VRFWAGRKNA FPAVGRISPD
360 370 380 390 400
YYCMDGTIPR RALPGVLEGI ARLSQQYDLR VANVFHAGDG NMHPLILFDA
410 420 430 440 450
NEPGEFARAE ELGGKILELC VEVGGSISGE HGIGREKINQ MCAQFNSDEI
460 470 480 490
TTFHAVKAAF DPDGLLNPGK NIPTLHRCAE FGAMHVHHGH LPFPELERF
Length:499
Mass (Da):53,812
Last modified:December 20, 2005 - v1
Checksum:i2D850E109DD1BA55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43490 Genomic DNA. Translation: AAB02530.1.
U28377 Genomic DNA. Translation: AAA69146.1.
U00096 Genomic DNA. Translation: AAC76015.1.
AP009048 Genomic DNA. Translation: BAE77040.1.
PIRiA65084.
RefSeqiNP_417453.1. NC_000913.3.
WP_000026117.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76015; AAC76015; b2979.
BAE77040; BAE77040; BAE77040.
GeneIDi947353.
KEGGiecj:JW2946.
eco:b2979.
PATRICi32121374. VBIEscCol129921_3074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43490 Genomic DNA. Translation: AAB02530.1.
U28377 Genomic DNA. Translation: AAA69146.1.
U00096 Genomic DNA. Translation: AAC76015.1.
AP009048 Genomic DNA. Translation: BAE77040.1.
PIRiA65084.
RefSeqiNP_417453.1. NC_000913.3.
WP_000026117.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AEP9.
SMRiP0AEP9. Positions 40-470.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262368. 16 interactions.
IntActiP0AEP9. 3 interactions.
STRINGi511145.b2979.

Proteomic databases

PaxDbiP0AEP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76015; AAC76015; b2979.
BAE77040; BAE77040; BAE77040.
GeneIDi947353.
KEGGiecj:JW2946.
eco:b2979.
PATRICi32121374. VBIEscCol129921_3074.

Organism-specific databases

EchoBASEiEB2820.
EcoGeneiEG12997. glcD.

Phylogenomic databases

eggNOGiENOG4105CQB. Bacteria.
COG0277. LUCA.
HOGENOMiHOG000230998.
InParanoidiP0AEP9.
KOiK00104.
OMAiTPRTCGE.
OrthoDBiEOG6RZB40.
PhylomeDBiP0AEP9.

Enzyme and pathway databases

BioCyciEcoCyc:G7545-MONOMER.
ECOL316407:JW2946-MONOMER.
MetaCyc:G7545-MONOMER.
RETL1328306-WGS:GSTH-5078-MONOMER.
RETL1328306-WGS:GSTH-817-MONOMER.

Miscellaneous databases

PROiP0AEP9.

Family and domain databases

Gene3Di1.10.45.10. 1 hit.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR016164. FAD-linked_Oxase-like_C.
IPR004113. FAD-linked_oxidase_C.
IPR004490. GlcD.
IPR006094. Oxid_FAD_bind_N.
IPR016171. Vanillyl_alc_oxidase_C-sub2.
[Graphical view]
PfamiPF02913. FAD-oxidase_C. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
SUPFAMiSSF55103. SSF55103. 1 hit.
SSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR00387. glcD. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "glc locus of Escherichia coli: characterization of genes encoding the subunits of glycolate oxidase and the glc regulator protein."
    Pellicer M.T., Badia J., Aguilar J.T., Baldoma L.
    J. Bacteriol. 178:2051-2059(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiGLCD_ECOLI
AccessioniPrimary (citable) accession number: P0AEP9
Secondary accession number(s): P52075, Q2M9L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: January 20, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.