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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

galU

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in stationary phase survival.

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Cofactori

GO - Molecular functioni

  • magnesium ion binding Source: EcoCyc
  • UTP:glucose-1-phosphate uridylyltransferase activity Source: EcoCyc

GO - Biological processi

  • colanic acid biosynthetic process Source: EcoCyc
  • galactose catabolic process via UDP-galactose Source: EcoCyc
  • lipopolysaccharide biosynthetic process Source: EcoCyc
  • UDP-glucose metabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciEcoCyc:GLUC1PURIDYLTRANS-MONOMER.
ECOL316407:JW1224-MONOMER.
MetaCyc:GLUC1PURIDYLTRANS-MONOMER.
BRENDAi2.7.7.9. 2026.
SABIO-RKP0AEP3.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:galU
Synonyms:ychD
Ordered Locus Names:b1236, JW1224
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11319. galU.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00002013542 – 302UTP--glucose-1-phosphate uridylyltransferaseAdd BLAST301

Proteomic databases

EPDiP0AEP3.
PaxDbiP0AEP3.
PRIDEiP0AEP3.

Interactioni

Subunit structurei

Homotetramer or homopentamer.

Protein-protein interaction databases

BioGridi4260121. 436 interactors.
DIPiDIP-35950N.
IntActiP0AEP3. 3 interactors.
STRINGi511145.b1236.

Structurei

Secondary structure

1302
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 14Combined sources5
Helixi20 – 22Combined sources3
Turni23 – 26Combined sources4
Beta strandi27 – 29Combined sources3
Helixi31 – 33Combined sources3
Helixi41 – 51Combined sources11
Beta strandi56 – 61Combined sources6
Helixi63 – 65Combined sources3
Helixi66 – 72Combined sources7
Helixi76 – 82Combined sources7
Helixi89 – 96Combined sources8
Beta strandi103 – 108Combined sources6
Helixi115 – 121Combined sources7
Helixi123 – 126Combined sources4
Beta strandi131 – 134Combined sources4
Beta strandi138 – 140Combined sources3
Turni147 – 149Combined sources3
Helixi152 – 162Combined sources11
Beta strandi165 – 171Combined sources7
Helixi175 – 177Combined sources3
Beta strandi178 – 182Combined sources5
Beta strandi193 – 196Combined sources4
Beta strandi198 – 202Combined sources5
Turni205 – 207Combined sources3
Beta strandi211 – 220Combined sources10
Helixi224 – 228Combined sources5
Helixi235 – 237Combined sources3
Helixi241 – 251Combined sources11
Beta strandi254 – 258Combined sources5
Beta strandi263 – 265Combined sources3
Helixi269 – 282Combined sources14
Turni284 – 286Combined sources3
Helixi287 – 297Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E3DX-ray1.95A/B/C/D1-302[»]
ProteinModelPortaliP0AEP3.
SMRiP0AEP3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AEP3.

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Phylogenomic databases

eggNOGiENOG4105C3Y. Bacteria.
COG1210. LUCA.
HOGENOMiHOG000283477.
InParanoidiP0AEP3.
KOiK00963.
OMAiIGYMQAF.
PhylomeDBiP0AEP3.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AEP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAINTKVKK AVIPVAGLGT RMLPATKAIP KEMLPLVDKP LIQYVVNECI
60 70 80 90 100
AAGITEIVLV THSSKNSIEN HFDTSFELEA MLEKRVKRQL LDEVQSICPP
110 120 130 140 150
HVTIMQVRQG LAKGLGHAVL CAHPVVGDEP VAVILPDVIL DEYESDLSQD
160 170 180 190 200
NLAEMIRRFD ETGHSQIMVE PVADVTAYGV VDCKGVELAP GESVPMVGVV
210 220 230 240 250
EKPKADVAPS NLAIVGRYVL SADIWPLLAK TPPGAGDEIQ LTDAIDMLIE
260 270 280 290 300
KETVEAYHMK GKSHDCGNKL GYMQAFVEYG IRHNTLGTEF KAWLEEEMGI

KK
Length:302
Mass (Da):32,942
Last modified:January 23, 2007 - v2
Checksum:iADEAEB3F6A1194CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59940 Genomic DNA. Translation: CAA42564.1.
M98830 Unassigned DNA. Translation: AAA20118.1.
U00096 Genomic DNA. Translation: AAC74318.1.
AP009048 Genomic DNA. Translation: BAA36104.1.
PIRiG64870. JC2265.
RefSeqiNP_415752.1. NC_000913.3.
WP_000718995.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74318; AAC74318; b1236.
BAA36104; BAA36104; BAA36104.
GeneIDi945730.
KEGGiecj:JW1224.
eco:b1236.
PATRICi32117728. VBIEscCol129921_1284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59940 Genomic DNA. Translation: CAA42564.1.
M98830 Unassigned DNA. Translation: AAA20118.1.
U00096 Genomic DNA. Translation: AAC74318.1.
AP009048 Genomic DNA. Translation: BAA36104.1.
PIRiG64870. JC2265.
RefSeqiNP_415752.1. NC_000913.3.
WP_000718995.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E3DX-ray1.95A/B/C/D1-302[»]
ProteinModelPortaliP0AEP3.
SMRiP0AEP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260121. 436 interactors.
DIPiDIP-35950N.
IntActiP0AEP3. 3 interactors.
STRINGi511145.b1236.

Proteomic databases

EPDiP0AEP3.
PaxDbiP0AEP3.
PRIDEiP0AEP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74318; AAC74318; b1236.
BAA36104; BAA36104; BAA36104.
GeneIDi945730.
KEGGiecj:JW1224.
eco:b1236.
PATRICi32117728. VBIEscCol129921_1284.

Organism-specific databases

EchoBASEiEB1295.
EcoGeneiEG11319. galU.

Phylogenomic databases

eggNOGiENOG4105C3Y. Bacteria.
COG1210. LUCA.
HOGENOMiHOG000283477.
InParanoidiP0AEP3.
KOiK00963.
OMAiIGYMQAF.
PhylomeDBiP0AEP3.

Enzyme and pathway databases

BioCyciEcoCyc:GLUC1PURIDYLTRANS-MONOMER.
ECOL316407:JW1224-MONOMER.
MetaCyc:GLUC1PURIDYLTRANS-MONOMER.
BRENDAi2.7.7.9. 2026.
SABIO-RKP0AEP3.

Miscellaneous databases

EvolutionaryTraceiP0AEP3.
PROiP0AEP3.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGALU_ECOLI
AccessioniPrimary (citable) accession number: P0AEP3
Secondary accession number(s): P25520
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.