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P0AEP1 (GALP_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Galactose-proton symporter
Alternative name(s):
Galactose transporter
Gene names
Name:galP
Ordered Locus Names:b2943, JW2910
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length464 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Uptake of galactose across the boundary membrane with the concomitant transport of protons into the cell (symport system).

Subcellular location

Cell inner membrane; Multi-pass membrane protein Ref.4.

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 464464Galactose-proton symporter
PRO_0000050292

Regions

Topological domain1 – 1515Cytoplasmic Potential
Transmembrane16 – 3621Helical; Name=1; Potential
Topological domain37 – 5620Periplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 847Cytoplasmic Potential
Transmembrane85 – 10521Helical; Name=3; Potential
Topological domain106 – 1127Periplasmic Potential
Transmembrane113 – 13321Helical; Name=4; Potential
Topological domain134 – 1396Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=5; Potential
Topological domain161 – 17111Periplasmic Potential
Transmembrane172 – 19221Helical; Name=6; Potential
Topological domain193 – 25058Cytoplasmic Potential
Transmembrane251 – 27121Helical; Name=7; Potential
Topological domain272 – 29019Periplasmic Potential
Transmembrane291 – 31121Helical; Name=8; Potential
Topological domain312 – 32110Cytoplasmic Potential
Transmembrane322 – 34221Helical; Name=9; Potential
Topological domain343 – 3519Periplasmic Potential
Transmembrane352 – 37221Helical; Name=10; Potential
Topological domain373 – 39422Cytoplasmic Potential
Transmembrane395 – 41521Helical; Name=11; Potential
Topological domain4161Periplasmic Potential
Transmembrane417 – 43721Helical; Name=12; Potential
Topological domain438 – 46427Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P0AEP1 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 07E08935BD8E3F8E

FASTA46450,983
        10         20         30         40         50         60 
MPDAKKQGRS NKAMTFFVCF LAALAGLLFG LDIGVIAGAL PFIADEFQIT SHTQEWVVSS 

        70         80         90        100        110        120 
MMFGAAVGAV GSGWLSFKLG RKKSLMIGAI LFVAGSLFSA AAPNVEVLIL SRVLLGLAVG 

       130        140        150        160        170        180 
VASYTAPLYL SEIAPEKIRG SMISMYQLMI TIGILGAYLS DTAFSYTGAW RWMLGVIIIP 

       190        200        210        220        230        240 
AILLLIGVFF LPDSPRWFAA KRRFVDAERV LLRLRDTSAE AKRELDEIRE SLQVKQSGWA 

       250        260        270        280        290        300 
LFKENSNFRR AVFLGVLLQV MQQFTGMNVI MYYAPKIFEL AGYTNTTEQM WGTVIVGLTN 

       310        320        330        340        350        360 
VLATFIAIGL VDRWGRKPTL TLGFLVMAAG MGVLGTMMHI GIHSPSAQYF AIAMLLMFIV 

       370        380        390        400        410        420 
GFAMSAGPLI WVLCSEIQPL KGRDFGITCS TATNWIANMI VGATFLTMLN TLGNANTFWV 

       430        440        450        460 
YAALNVLFIL LTLWLVPETK HVSLEHIERN LMKGRKLREI GAHD

« Hide

References

« Hide 'large scale' references
[1]Roberts P.E.
Thesis (1992), University of Cambridge, United Kingdom
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Global topology analysis of the Escherichia coli inner membrane proteome."
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U28377 Genomic DNA. Translation: AAA69110.1.
U00096 Genomic DNA. Translation: AAC75980.1.
AP009048 Genomic DNA. Translation: BAE77006.1.
PIRF65079.
RefSeqNP_417418.1. NC_000913.2.
YP_491142.1. NC_007779.1.

3D structure databases

ProteinModelPortalP0AEP1.
SMRP0AEP1. Positions 11-448.
ModBaseSearch...

Protein-protein interaction databases

STRING511145.b2943.

Protein family/group databases

TCDB2.A.1.1.1. major facilitator superfamily (MFS).

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC75980; AAC75980; b2943.
BAE77006; BAE77006; BAE77006.
GeneID12931664.
947434.
KEGGecj:Y75_p2873.
eco:b2943.
PATRIC32121296. VBIEscCol129921_3036.

Organism-specific databases

EchoBASEEB2068.
EcoGeneEG12148. galP.

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000202868.
KOK08137.
OMAIFWAYNF.
ProtClustDBCLSK880537.

Enzyme and pathway databases

BioCycEcoCyc:GALP-MONOMER.
ECOL316407:JW2910-MONOMER.

Gene expression databases

GenevestigatorP0AEP1.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR00171. SUGRTRNSPORT.
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGALP_ECOLI
AccessionPrimary (citable) accession number: P0AEP1
Secondary accession number(s): P37021, Q2M9Q0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

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