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Protein

Cell division protein FtsL

Gene

ftsL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. Can also mediate Zn2+-sensitivity probably by increasing the permeability of the inner membrane.UniRule annotation3 Publications

GO - Biological processi

  • FtsZ-dependent cytokinesis Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciEcoCyc:EG11086-MONOMER.
ECOL316407:JW0081-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsLUniRule annotation
Gene namesi
Name:ftsLUniRule annotation
Synonyms:mraR, yabD
Ordered Locus Names:b0083, JW0081
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11086. ftsL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434CytoplasmicUniRule annotationAdd
BLAST
Transmembranei35 – 5723HelicalUniRule annotationAdd
BLAST
Topological domaini58 – 12164PeriplasmicUniRule annotationAdd
BLAST

GO - Cellular componenti

  • cell division site Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutants show inhibition of cell division, formation of long, nonseptate filaments, ultimate cessation of growth and lysis.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi70 – 701L → H: Impairs both localization and function, and reduces the efficiency of dimerization. 1 Publication
Mutagenesisi84 – 841L → D: Impairs both localization and function, and reduces the efficiency of dimerization. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 121121Cell division protein FtsLPRO_0000087371Add
BLAST

Proteomic databases

PaxDbiP0AEN4.

Interactioni

Subunit structurei

Part of a complex composed of FtsB, FtsL and FtsQ. The complex can be formed before its localization to the division site. This tripartite complex can be divided further into a subcomplex of FtsB and FtsL, which forms in the absence of FtsQ. Interacts also with FtsI, FtsN and YmgF. Homodimer in vitro. May form multimers.UniRule annotation5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
blrP569763EBI-1119082,EBI-6419495
ftsBP0A6S518EBI-1119082,EBI-1113953
ftsIP0AD684EBI-1119082,EBI-548564
ftsQP0613611EBI-1119082,EBI-1130157
ymgFP580343EBI-1119082,EBI-1214577

Protein-protein interaction databases

BioGridi4261638. 326 interactions.
DIPiDIP-47987N.
IntActiP0AEN4. 17 interactions.
MINTiMINT-1031895.
STRINGi511145.b0083.

Structurei

3D structure databases

ProteinModelPortaliP0AEN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili63 – 9129Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi58 – 8528Leucine zipper-likeAdd
BLAST

Domaini

The cytoplasmic region is involved in recruitment of the downstream cell division protein FtsW. The transmembrane segment and the membrane-proximal periplasmic region form a coiled-coil structure and are required for septal localization and interaction with FtsB. The C-terminal region is required for interaction with FtsQ. Contains a leucine zipper-like (LZ) motif, which is required for optimal interaction with FtsB.2 Publications

Sequence similaritiesi

Belongs to the FtsL family.UniRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41063Y6. Bacteria.
COG3116. LUCA.
HOGENOMiHOG000255861.
InParanoidiP0AEN4.
KOiK03586.
OMAiVWITHQT.

Family and domain databases

HAMAPiMF_00910. FtsL. 1 hit.
InterProiIPR011922. Cell_div_FtsL.
[Graphical view]
PfamiPF04999. FtsL. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02209. ftsL_broad. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AEN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISRVTEALS KVKGSMGSHE RHALPGVIGD DLLRFGKLPL CLFICIILTA
60 70 80 90 100
VTVVTTAHHT RLLTAQREQL VLERDALDIE WRNLILEENA LGDHSRVERI
110 120
ATEKLQMQHV DPSQENIVVQ K
Length:121
Mass (Da):13,627
Last modified:December 20, 2005 - v1
Checksum:i6DD5DF7B2ECB7090
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S49875 Genomic DNA. Translation: AAB24309.1.
S49802 Genomic DNA. Translation: AAB24311.1.
X55034 Genomic DNA. Translation: CAA38860.1.
U00096 Genomic DNA. Translation: AAC73194.1.
AP009048 Genomic DNA. Translation: BAB96651.2.
K00137 Genomic DNA. Translation: AAA24299.1.
X52063 Genomic DNA. Translation: CAA36285.1.
PIRiA45278.
RefSeqiNP_414625.1. NC_000913.3.
WP_000625658.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73194; AAC73194; b0083.
BAB96651; BAB96651; BAB96651.
GeneIDi944803.
KEGGiecj:JW0081.
eco:b0083.
PATRICi32115271. VBIEscCol129921_0087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S49875 Genomic DNA. Translation: AAB24309.1.
S49802 Genomic DNA. Translation: AAB24311.1.
X55034 Genomic DNA. Translation: CAA38860.1.
U00096 Genomic DNA. Translation: AAC73194.1.
AP009048 Genomic DNA. Translation: BAB96651.2.
K00137 Genomic DNA. Translation: AAA24299.1.
X52063 Genomic DNA. Translation: CAA36285.1.
PIRiA45278.
RefSeqiNP_414625.1. NC_000913.3.
WP_000625658.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AEN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261638. 326 interactions.
DIPiDIP-47987N.
IntActiP0AEN4. 17 interactions.
MINTiMINT-1031895.
STRINGi511145.b0083.

Proteomic databases

PaxDbiP0AEN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73194; AAC73194; b0083.
BAB96651; BAB96651; BAB96651.
GeneIDi944803.
KEGGiecj:JW0081.
eco:b0083.
PATRICi32115271. VBIEscCol129921_0087.

Organism-specific databases

EchoBASEiEB1078.
EcoGeneiEG11086. ftsL.

Phylogenomic databases

eggNOGiENOG41063Y6. Bacteria.
COG3116. LUCA.
HOGENOMiHOG000255861.
InParanoidiP0AEN4.
KOiK03586.
OMAiVWITHQT.

Enzyme and pathway databases

BioCyciEcoCyc:EG11086-MONOMER.
ECOL316407:JW0081-MONOMER.

Miscellaneous databases

PROiP0AEN4.

Family and domain databases

HAMAPiMF_00910. FtsL. 1 hit.
InterProiIPR011922. Cell_div_FtsL.
[Graphical view]
PfamiPF04999. FtsL. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02209. ftsL_broad. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFTSL_ECOLI
AccessioniPrimary (citable) accession number: P0AEN4
Secondary accession number(s): P22187, Q8KMX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.