P0AEN2 (FRE_ECOL6) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 49.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: NAD(P)H-flavin reductase EC=1.16.1.3 EC=1.5.1.41 Alternative name(s): Aquacobalamin reductase FMN reductase Ferrisiderophore reductase C NAD(P)H:flavin oxidoreductase Riboflavin reductase [NAD(P)H] | ||||||
| Gene names |
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| Organism | Escherichia coli O6 [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 217992 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 233 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. Seems to reduces the complexed Fe3+ iron of siderophores to Fe2+, thus releasing it from the chelator By similarity. |
| Catalytic activity | Reduced riboflavin + NAD(P)+ = riboflavin + NAD(P)H. 2 cob(II)alamin + NAD+ = 2 aquacob(III)alamin + NADH. |
| Subunit structure | Monomer By similarity. |
| Sequence similarities | Belongs to the fre/luxG FAD/NAD(P) flavoprotein oxidoreductase family. Contains 1 FAD-binding FR-type domain. |
| Sequence caution | The sequence AAN83224.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ion transport Iron transport Transport |
| Ligand | FAD FMN Flavoprotein Iron NAD NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | ion transport Inferred from electronic annotation. Source: UniProtKB-KW iron ion homeostasisInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | aquacobalamin reductase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed: 12471157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O6:H1 / CFT073 / ATCC 700928 / UPEC. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE014075 Genomic DNA. Translation: AAN83224.1. Different initiation. |
| RefSeq | NP_756650.2. NC_004431.1. |
3D structure databases | |
| ProteinModelPortal | P0AEN2. |
| SMR | P0AEN2. Positions 2-233. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000044962; EBESCP00000043311; EBESCG00000044012. |
| GeneID | 1035669. |
| GenomeReviews | Gene locus c4791 in contig AE014075_GR. |
| KEGG | ecc:c4791. |
| PATRIC | 18287265. VBIEscCol75197_4496. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000009405. |
| HOGENOM | HBG625960. |
| OMA | ARDLFCN. |
| ProtClustDB | PRK08051. |
Family and domain databases | |
| InterPro | IPR017927. Fd_Rdtase_FAD-bd. IPR008333. OxRdtase_FAD-bd_dom. IPR001433. OxRdtase_FAD/NAD-bd. IPR001221. Phe_hydroxylase. IPR017938. Riboflavin_synthase-like_b-brl. [Graphical view] |
| KO | K05368. |
| Pfam | PF00970. FAD_binding_6. 1 hit. PF00175. NAD_binding_1. 1 hit. [Graphical view] |
| PRINTS | PR00410. PHEHYDRXLASE. |
| SUPFAM | SSF63380. Riboflavin_synthase_like_b-brl. 1 hit. |
| PROSITE | PS51384. FAD_FR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FRE_ECOL6 | ||||||||
| Accession | Primary (citable) accession number: P0AEN2 Secondary accession number(s): P23486, P76768 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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