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P0AEM8

- FLIA_ECO57

UniProt

P0AEM8 - FLIA_ECO57

Protein

RNA polymerase sigma factor FliA

Gene

fliA

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi207 – 22620H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. DNA-directed RNA polymerase activity Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. sigma factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. transcription initiation from bacterial-type RNA polymerase promoter Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Sigma factor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-2628-MONOMER.
    ECOO157:FLIA-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase sigma factor FliAUniRule annotation
    Alternative name(s):
    RNA polymerase sigma factor for flagellar operonUniRule annotation
    Sigma FUniRule annotation
    Sigma-28UniRule annotation
    Gene namesi
    Name:fliAUniRule annotation
    Ordered Locus Names:Z3012, ECs2661
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239RNA polymerase sigma factor FliAPRO_0000093982Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi155864.Z3012.

    Structurei

    3D structure databases

    ProteinModelPortaliP0AEM8.
    SMRiP0AEM8. Positions 11-236.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni16 – 8873Sigma-70 factor domain-2UniRule annotationAdd
    BLAST
    Regioni96 – 16671Sigma-70 factor domain-3UniRule annotationAdd
    BLAST
    Regioni185 – 23349Sigma-70 factor domain-4UniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 464Interaction with polymerase core subunit RpoC

    Sequence similaritiesi

    Belongs to the sigma-70 factor family. FliA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1191.
    HOGENOMiHOG000270271.
    KOiK02405.
    OMAiNPLHQLM.
    OrthoDBiEOG661H9F.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    HAMAPiMF_00962. Sigma70_FliA.
    InterProiIPR014284. RNA_pol_sigma-70_dom.
    IPR000943. RNA_pol_sigma70.
    IPR007627. RNA_pol_sigma70_r2.
    IPR007624. RNA_pol_sigma70_r3.
    IPR007630. RNA_pol_sigma70_r4.
    IPR012845. RNA_pol_sigma_FliA_WhiG.
    IPR013325. RNA_pol_sigma_r2.
    IPR013324. RNA_pol_sigma_r3_r4.
    IPR028617. Sigma70_FliA.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF04542. Sigma70_r2. 1 hit.
    PF04539. Sigma70_r3. 1 hit.
    PF04545. Sigma70_r4. 1 hit.
    [Graphical view]
    PRINTSiPR00046. SIGMA70FCT.
    SUPFAMiSSF88659. SSF88659. 2 hits.
    SSF88946. SSF88946. 1 hit.
    TIGRFAMsiTIGR02479. FliA_WhiG. 1 hit.
    TIGR02937. sigma70-ECF. 1 hit.
    PROSITEiPS00715. SIGMA70_1. 1 hit.
    PS00716. SIGMA70_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0AEM8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSLYTAEGV MDKHSLWQRY VPLVRHEALR LQVRLPASVE LDDLLQAGGI    50
    GLLNAVERYD ALQGTAFTTY AVQRIRGAML DELRSRDWVP RSVRRNAREV 100
    AQAIGQLEQE LGRNATETEV AERLGIDIAD YRQMLLDTNN SQLFSYDEWR 150
    EEHGDSIELV TDDHQRENPL QQLLDSNLRQ RVMEAIETLP EREKLVLTLY 200
    YQEELNLKEI GAVLEVGESR VSQLHSQAIK RLRTKLGKL 239
    Length:239
    Mass (Da):27,521
    Last modified:December 20, 2005 - v1
    Checksum:iB2930B44E1F24A33
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG56937.1.
    BA000007 Genomic DNA. Translation: BAB36084.1.
    PIRiE85809.
    E90961.
    RefSeqiNP_288383.1. NC_002655.2.
    NP_310688.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG56937; AAG56937; Z3012.
    BAB36084; BAB36084; BAB36084.
    GeneIDi914052.
    961920.
    KEGGiece:Z3012.
    ecs:ECs2661.
    PATRICi18354706. VBIEscCol44059_2561.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG56937.1 .
    BA000007 Genomic DNA. Translation: BAB36084.1 .
    PIRi E85809.
    E90961.
    RefSeqi NP_288383.1. NC_002655.2.
    NP_310688.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali P0AEM8.
    SMRi P0AEM8. Positions 11-236.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z3012.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG56937 ; AAG56937 ; Z3012 .
    BAB36084 ; BAB36084 ; BAB36084 .
    GeneIDi 914052.
    961920.
    KEGGi ece:Z3012.
    ecs:ECs2661.
    PATRICi 18354706. VBIEscCol44059_2561.

    Phylogenomic databases

    eggNOGi COG1191.
    HOGENOMi HOG000270271.
    KOi K02405.
    OMAi NPLHQLM.
    OrthoDBi EOG661H9F.

    Enzyme and pathway databases

    BioCyci ECOL386585:GJFA-2628-MONOMER.
    ECOO157:FLIA-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    HAMAPi MF_00962. Sigma70_FliA.
    InterProi IPR014284. RNA_pol_sigma-70_dom.
    IPR000943. RNA_pol_sigma70.
    IPR007627. RNA_pol_sigma70_r2.
    IPR007624. RNA_pol_sigma70_r3.
    IPR007630. RNA_pol_sigma70_r4.
    IPR012845. RNA_pol_sigma_FliA_WhiG.
    IPR013325. RNA_pol_sigma_r2.
    IPR013324. RNA_pol_sigma_r3_r4.
    IPR028617. Sigma70_FliA.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF04542. Sigma70_r2. 1 hit.
    PF04539. Sigma70_r3. 1 hit.
    PF04545. Sigma70_r4. 1 hit.
    [Graphical view ]
    PRINTSi PR00046. SIGMA70FCT.
    SUPFAMi SSF88659. SSF88659. 2 hits.
    SSF88946. SSF88946. 1 hit.
    TIGRFAMsi TIGR02479. FliA_WhiG. 1 hit.
    TIGR02937. sigma70-ECF. 1 hit.
    PROSITEi PS00715. SIGMA70_1. 1 hit.
    PS00716. SIGMA70_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiFLIA_ECO57
    AccessioniPrimary (citable) accession number: P0AEM8
    Secondary accession number(s): P31804
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3