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P0AEM8

- FLIA_ECO57

UniProt

P0AEM8 - FLIA_ECO57

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Protein

RNA polymerase sigma factor FliA

Gene

fliA

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi207 – 22620H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. DNA-directed RNA polymerase activity Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. sigma factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. transcription initiation from bacterial-type RNA polymerase promoter Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Sigma factor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciECOL386585:GJFA-2628-MONOMER.
ECOO157:FLIA-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor FliAUniRule annotation
Alternative name(s):
RNA polymerase sigma factor for flagellar operonUniRule annotation
Sigma FUniRule annotation
Sigma-28UniRule annotation
Gene namesi
Name:fliAUniRule annotation
Ordered Locus Names:Z3012, ECs2661
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239RNA polymerase sigma factor FliAPRO_0000093982Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi155864.Z3012.

Structurei

3D structure databases

ProteinModelPortaliP0AEM8.
SMRiP0AEM8. Positions 11-236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni16 – 8873Sigma-70 factor domain-2UniRule annotationAdd
BLAST
Regioni96 – 16671Sigma-70 factor domain-3UniRule annotationAdd
BLAST
Regioni185 – 23349Sigma-70 factor domain-4UniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 464Interaction with polymerase core subunit RpoC

Sequence similaritiesi

Belongs to the sigma-70 factor family. FliA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1191.
HOGENOMiHOG000270271.
KOiK02405.
OMAiNPLHQLM.
OrthoDBiEOG661H9F.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
HAMAPiMF_00962. Sigma70_FliA.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR012845. RNA_pol_sigma_FliA_WhiG.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR028617. Sigma70_FliA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view]
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02479. FliA_WhiG. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AEM8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSLYTAEGV MDKHSLWQRY VPLVRHEALR LQVRLPASVE LDDLLQAGGI
60 70 80 90 100
GLLNAVERYD ALQGTAFTTY AVQRIRGAML DELRSRDWVP RSVRRNAREV
110 120 130 140 150
AQAIGQLEQE LGRNATETEV AERLGIDIAD YRQMLLDTNN SQLFSYDEWR
160 170 180 190 200
EEHGDSIELV TDDHQRENPL QQLLDSNLRQ RVMEAIETLP EREKLVLTLY
210 220 230
YQEELNLKEI GAVLEVGESR VSQLHSQAIK RLRTKLGKL
Length:239
Mass (Da):27,521
Last modified:December 20, 2005 - v1
Checksum:iB2930B44E1F24A33
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG56937.1.
BA000007 Genomic DNA. Translation: BAB36084.1.
PIRiE85809.
E90961.
RefSeqiNP_288383.1. NC_002655.2.
NP_310688.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG56937; AAG56937; Z3012.
BAB36084; BAB36084; BAB36084.
GeneIDi914052.
961920.
KEGGiece:Z3012.
ecs:ECs2661.
PATRICi18354706. VBIEscCol44059_2561.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG56937.1 .
BA000007 Genomic DNA. Translation: BAB36084.1 .
PIRi E85809.
E90961.
RefSeqi NP_288383.1. NC_002655.2.
NP_310688.1. NC_002695.1.

3D structure databases

ProteinModelPortali P0AEM8.
SMRi P0AEM8. Positions 11-236.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z3012.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG56937 ; AAG56937 ; Z3012 .
BAB36084 ; BAB36084 ; BAB36084 .
GeneIDi 914052.
961920.
KEGGi ece:Z3012.
ecs:ECs2661.
PATRICi 18354706. VBIEscCol44059_2561.

Phylogenomic databases

eggNOGi COG1191.
HOGENOMi HOG000270271.
KOi K02405.
OMAi NPLHQLM.
OrthoDBi EOG661H9F.

Enzyme and pathway databases

BioCyci ECOL386585:GJFA-2628-MONOMER.
ECOO157:FLIA-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
HAMAPi MF_00962. Sigma70_FliA.
InterProi IPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR012845. RNA_pol_sigma_FliA_WhiG.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR028617. Sigma70_FliA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view ]
PRINTSi PR00046. SIGMA70FCT.
SUPFAMi SSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsi TIGR02479. FliA_WhiG. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEi PS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiFLIA_ECO57
AccessioniPrimary (citable) accession number: P0AEM8
Secondary accession number(s): P31804
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3