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Protein

RNA polymerase sigma factor FliA

Gene

fliA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi207 – 226H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Sigma factor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor FliAUniRule annotation
Alternative name(s):
RNA polymerase sigma factor for flagellar operonUniRule annotation
Sigma FUniRule annotation
Sigma-28UniRule annotation
Gene namesi
Name:fliAUniRule annotation
Ordered Locus Names:Z3012, ECs2661
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000939821 – 239RNA polymerase sigma factor FliAAdd BLAST239

Proteomic databases

PRIDEiP0AEM8

Interactioni

Protein-protein interaction databases

STRINGi155864.Z3012

Structurei

3D structure databases

ProteinModelPortaliP0AEM8
SMRiP0AEM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 88Sigma-70 factor domain-2UniRule annotationAdd BLAST73
Regioni96 – 166Sigma-70 factor domain-3UniRule annotationAdd BLAST71
Regioni185 – 233Sigma-70 factor domain-4UniRule annotationAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 46Interaction with polymerase core subunit RpoC4

Sequence similaritiesi

Belongs to the sigma-70 factor family. FliA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DN4 Bacteria
COG1191 LUCA
HOGENOMiHOG000270271
KOiK02405
OMAiIKFETYA

Family and domain databases

HAMAPiMF_00962 Sigma70_FliA, 1 hit
InterProiView protein in InterPro
IPR014284 RNA_pol_sigma-70_dom
IPR000943 RNA_pol_sigma70
IPR007627 RNA_pol_sigma70_r2
IPR007624 RNA_pol_sigma70_r3
IPR007630 RNA_pol_sigma70_r4
IPR012845 RNA_pol_sigma_FliA_WhiG
IPR013325 RNA_pol_sigma_r2
IPR013324 RNA_pol_sigma_r3/r4-like
IPR028617 Sigma70_FliA
PfamiView protein in Pfam
PF04542 Sigma70_r2, 1 hit
PF04539 Sigma70_r3, 1 hit
PF04545 Sigma70_r4, 1 hit
PIRSFiPIRSF000770 RNA_pol_sigma-SigE/K, 1 hit
PRINTSiPR00046 SIGMA70FCT
SUPFAMiSSF88659 SSF88659, 2 hits
SSF88946 SSF88946, 1 hit
TIGRFAMsiTIGR02479 FliA_WhiG, 1 hit
TIGR02937 sigma70-ECF, 1 hit
PROSITEiView protein in PROSITE
PS00715 SIGMA70_1, 1 hit
PS00716 SIGMA70_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0AEM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSLYTAEGV MDKHSLWQRY VPLVRHEALR LQVRLPASVE LDDLLQAGGI
60 70 80 90 100
GLLNAVERYD ALQGTAFTTY AVQRIRGAML DELRSRDWVP RSVRRNAREV
110 120 130 140 150
AQAIGQLEQE LGRNATETEV AERLGIDIAD YRQMLLDTNN SQLFSYDEWR
160 170 180 190 200
EEHGDSIELV TDDHQRENPL QQLLDSNLRQ RVMEAIETLP EREKLVLTLY
210 220 230
YQEELNLKEI GAVLEVGESR VSQLHSQAIK RLRTKLGKL
Length:239
Mass (Da):27,521
Last modified:December 20, 2005 - v1
Checksum:iB2930B44E1F24A33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG56937.1
BA000007 Genomic DNA Translation: BAB36084.1
PIRiE85809
E90961
RefSeqiNP_310688.1, NC_002695.1
WP_001087467.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG56937; AAG56937; Z3012
BAB36084; BAB36084; BAB36084
GeneIDi914052
KEGGiece:Z3012
ecs:ECs2661
PATRICifig|386585.9.peg.2788

Similar proteinsi

Entry informationi

Entry nameiFLIA_ECO57
AccessioniPrimary (citable) accession number: P0AEM8
Secondary accession number(s): P31804
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health