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Protein

RNA polymerase sigma factor FliA

Gene

fliA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi207 – 226H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Sigma factor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor FliAUniRule annotation
Alternative name(s):
RNA polymerase sigma factor for flagellar operonUniRule annotation
Sigma FUniRule annotation
Sigma-28UniRule annotation
Gene namesi
Name:fliAUniRule annotation
Ordered Locus Names:Z3012, ECs2661
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000939821 – 239RNA polymerase sigma factor FliAAdd BLAST239

Proteomic databases

PRIDEiP0AEM8.

Interactioni

Protein-protein interaction databases

STRINGi155864.Z3012.

Structurei

3D structure databases

ProteinModelPortaliP0AEM8.
SMRiP0AEM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 88Sigma-70 factor domain-2UniRule annotationAdd BLAST73
Regioni96 – 166Sigma-70 factor domain-3UniRule annotationAdd BLAST71
Regioni185 – 233Sigma-70 factor domain-4UniRule annotationAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 46Interaction with polymerase core subunit RpoC4

Sequence similaritiesi

Belongs to the sigma-70 factor family. FliA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DN4. Bacteria.
COG1191. LUCA.
HOGENOMiHOG000270271.
KOiK02405.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
HAMAPiMF_00962. Sigma70_FliA. 1 hit.
InterProiView protein in InterPro
IPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR012845. RNA_pol_sigma_FliA_WhiG.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR028617. Sigma70_FliA.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
PIRSFiPIRSF000770. RNA_pol_sigma-SigE/K. 1 hit.
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02479. FliA_WhiG. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEiView protein in PROSITE
PS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AEM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSLYTAEGV MDKHSLWQRY VPLVRHEALR LQVRLPASVE LDDLLQAGGI
60 70 80 90 100
GLLNAVERYD ALQGTAFTTY AVQRIRGAML DELRSRDWVP RSVRRNAREV
110 120 130 140 150
AQAIGQLEQE LGRNATETEV AERLGIDIAD YRQMLLDTNN SQLFSYDEWR
160 170 180 190 200
EEHGDSIELV TDDHQRENPL QQLLDSNLRQ RVMEAIETLP EREKLVLTLY
210 220 230
YQEELNLKEI GAVLEVGESR VSQLHSQAIK RLRTKLGKL
Length:239
Mass (Da):27,521
Last modified:December 20, 2005 - v1
Checksum:iB2930B44E1F24A33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG56937.1.
BA000007 Genomic DNA. Translation: BAB36084.1.
PIRiE85809.
E90961.
RefSeqiNP_310688.1. NC_002695.1.
WP_001087467.1. NZ_MWVM01000031.1.

Genome annotation databases

EnsemblBacteriaiAAG56937; AAG56937; Z3012.
BAB36084; BAB36084; BAB36084.
GeneIDi914052.
KEGGiece:Z3012.
ecs:ECs2661.
PATRICifig|386585.9.peg.2788.

Similar proteinsi

Entry informationi

Entry nameiFLIA_ECO57
AccessioniPrimary (citable) accession number: P0AEM8
Secondary accession number(s): P31804
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 27, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families