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Protein

Negative regulator of flagellin synthesis

Gene

flgM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

GO - Molecular functioni

  • sigma factor antagonist activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processBacterial flagellum biogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G369-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Negative regulator of flagellin synthesis
Alternative name(s):
Anti-sigma-28 factor
Gene namesi
Name:flgM
Ordered Locus Names:b1071, JW1058
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12664. flgM.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000872831 – 97Negative regulator of flagellin synthesisAdd BLAST97

Proteomic databases

PaxDbiP0AEM4.
PRIDEiP0AEM4.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
fliAP0AEM64EBI-1121952,EBI-549807

Protein-protein interaction databases

IntActiP0AEM4. 13 interactors.
STRINGi316385.ECDH10B_1142.

Structurei

3D structure databases

ProteinModelPortaliP0AEM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FlgM family.Curated

Phylogenomic databases

eggNOGiENOG4105M9M. Bacteria.
COG2747. LUCA.
HOGENOMiHOG000265658.
KOiK02398.

Family and domain databases

Gene3Di1.10.287.1160. 1 hit.
InterProiView protein in InterPro
IPR035890. Anti-sigma-28_factor_FlgM_sf.
IPR007412. FlgM.
IPR031316. FlgM_C.
PfamiView protein in Pfam
PF04316. FlgM. 1 hit.
SUPFAMiSSF101498. SSF101498. 1 hit.
TIGRFAMsiTIGR03824. FlgM_jcvi. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AEM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIDRTSPLK PVSTVQPRET TDAPVTNSRA AKTTASTSTS VTLSDAQAKL
60 70 80 90
MQPGSSDINL ERVEALKLAI RNGELKMDTG KIADALINEA QQDLQSN
Length:97
Mass (Da):10,341
Last modified:December 20, 2005 - v1
Checksum:i367D6F63324BF75D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19773 Genomic DNA. Translation: AAA61762.1.
U00096 Genomic DNA. Translation: AAC74155.1.
AP009048 Genomic DNA. Translation: BAA35879.1.
PIRiD64850.
RefSeqiNP_415589.1. NC_000913.3.
WP_000020880.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74155; AAC74155; b1071.
BAA35879; BAA35879; BAA35879.
GeneIDi946684.
KEGGiecj:JW1058.
eco:b1071.
PATRICifig|1411691.4.peg.1197.

Similar proteinsi

Entry informationi

Entry nameiFLGM_ECOLI
AccessioniPrimary (citable) accession number: P0AEM4
Secondary accession number(s): P43532
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: October 25, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families