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P0AEL6

- FEPB_ECOLI

UniProt

P0AEL6 - FEPB_ECOLI

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Protein

Ferrienterobactin-binding periplasmic protein

Gene

fepB

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Binds ferrienterobactin; part of the binding-protein-dependent transport system for uptake of ferrienterobactin.

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: EcoliWiki
  2. ion transport Source: UniProtKB-KW
  3. iron ion homeostasis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciEcoCyc:FEPB-MONOMER.
ECOL316407:JW0584-MONOMER.
MetaCyc:FEPB-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferrienterobactin-binding periplasmic protein
Gene namesi
Name:fepB
Ordered Locus Names:b0592, JW0584
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10294. fepB.

Subcellular locationi

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 318292Ferrienterobactin-binding periplasmic proteinPRO_0000031821Add
BLAST

Proteomic databases

PaxDbiP0AEL6.
PRIDEiP0AEL6.

Expressioni

Inductioni

Controlled in part by the amount of available iron.

Gene expression databases

GenevestigatoriP0AEL6.

Interactioni

Protein-protein interaction databases

DIPiDIP-9593N.
IntActiP0AEL6. 14 interactions.
STRINGi511145.b0592.

Structurei

Secondary structure

1
318
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 356
Beta strandi38 – 425
Beta strandi47 – 526
Helixi54 – 629
Beta strandi67 – 726
Turni77 – 793
Helixi87 – 893
Helixi90 – 956
Beta strandi99 – 1057
Helixi108 – 1125
Beta strandi117 – 1259
Helixi130 – 1323
Helixi133 – 1375
Beta strandi142 – 1454
Beta strandi148 – 1503
Helixi152 – 16312
Helixi166 – 18621
Beta strandi191 – 20010
Turni201 – 2044
Beta strandi205 – 2095
Beta strandi211 – 2133
Helixi214 – 2218
Helixi233 – 2364
Beta strandi243 – 2486
Helixi252 – 2565
Beta strandi259 – 2646
Helixi269 – 2779
Helixi279 – 2813
Helixi285 – 2884
Beta strandi292 – 2943
Helixi297 – 2993
Helixi304 – 31815

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2M6KNMR-A27-318[»]
2M6LNMR-A27-318[»]
3TLKX-ray1.85A/B/C1-318[»]
ProteinModelPortaliP0AEL6.
SMRiP0AEL6. Positions 27-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 318271Fe/B12 periplasmic-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Fe/B12 periplasmic-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4592.
HOGENOMiHOG000117867.
InParanoidiP0AEL6.
KOiK02016.
OMAiWTAESAQ.
OrthoDBiEOG61CM39.
PhylomeDBiP0AEL6.

Family and domain databases

InterProiIPR002491. ABC_transptr_periplasmic_BD.
[Graphical view]
PfamiPF01497. Peripla_BP_2. 1 hit.
[Graphical view]
PROSITEiPS50983. FE_B12_PBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AEL6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLAPLYRNA LLLTGLLLSG IAAVQAADWP RQITDSRGTH TLESQPQRIV
60 70 80 90 100
STSVTLTGSL LAIDAPVIAS GATTPNNRVA DDQGFLRQWS KVAKERKLQR
110 120 130 140 150
LYIGEPSAEA VAAQMPDLIL ISATGGDSAL ALYDQLSTIA PTLIINYDDK
160 170 180 190 200
SWQSLLTQLG EITGHEKQAA ERIAQFDKQL AAAKEQIKLP PQPVTAIVYT
210 220 230 240 250
AAAHSANLWT PESAQGQMLE QLGFTLAKLP AGLNASQSQG KRHDIIQLGG
260 270 280 290 300
ENLAAGLNGE SLFLFAGDQK DADAIYANPL LAHLPAVQNK QVYALGTETF
310
RLDYYSAMQV LDRLKALF
Length:318
Mass (Da):34,283
Last modified:December 20, 2005 - v1
Checksum:i807676D03A508079
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29730 Genomic DNA. Translation: AAA83853.1.
U82598 Genomic DNA. Translation: AAB40791.1.
U00096 Genomic DNA. Translation: AAC73693.1.
AP009048 Genomic DNA. Translation: BAE76347.1.
X53274 Genomic DNA. Translation: CAA37370.1.
PIRiJV0045.
RefSeqiNP_415124.1. NC_000913.3.
YP_488881.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73693; AAC73693; b0592.
BAE76347; BAE76347; BAE76347.
GeneIDi12931986.
947538.
KEGGiecj:Y75_p0581.
eco:b0592.
PATRICi32116360. VBIEscCol129921_0620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29730 Genomic DNA. Translation: AAA83853.1 .
U82598 Genomic DNA. Translation: AAB40791.1 .
U00096 Genomic DNA. Translation: AAC73693.1 .
AP009048 Genomic DNA. Translation: BAE76347.1 .
X53274 Genomic DNA. Translation: CAA37370.1 .
PIRi JV0045.
RefSeqi NP_415124.1. NC_000913.3.
YP_488881.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2M6K NMR - A 27-318 [» ]
2M6L NMR - A 27-318 [» ]
3TLK X-ray 1.85 A/B/C 1-318 [» ]
ProteinModelPortali P0AEL6.
SMRi P0AEL6. Positions 27-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-9593N.
IntActi P0AEL6. 14 interactions.
STRINGi 511145.b0592.

Proteomic databases

PaxDbi P0AEL6.
PRIDEi P0AEL6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC73693 ; AAC73693 ; b0592 .
BAE76347 ; BAE76347 ; BAE76347 .
GeneIDi 12931986.
947538.
KEGGi ecj:Y75_p0581.
eco:b0592.
PATRICi 32116360. VBIEscCol129921_0620.

Organism-specific databases

EchoBASEi EB0290.
EcoGenei EG10294. fepB.

Phylogenomic databases

eggNOGi COG4592.
HOGENOMi HOG000117867.
InParanoidi P0AEL6.
KOi K02016.
OMAi WTAESAQ.
OrthoDBi EOG61CM39.
PhylomeDBi P0AEL6.

Enzyme and pathway databases

BioCyci EcoCyc:FEPB-MONOMER.
ECOL316407:JW0584-MONOMER.
MetaCyc:FEPB-MONOMER.

Miscellaneous databases

PROi P0AEL6.

Gene expression databases

Genevestigatori P0AEL6.

Family and domain databases

InterProi IPR002491. ABC_transptr_periplasmic_BD.
[Graphical view ]
Pfami PF01497. Peripla_BP_2. 1 hit.
[Graphical view ]
PROSITEi PS50983. FE_B12_PBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and regulation of the Escherichia coli gene for ferrienterobactin transport protein FepB."
    Elkins M.F., Earhart C.F.
    J. Bacteriol. 171:5443-5451(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Regulation of divergent transcription from the iron-responsive fepB-entC promoter-operator regions in Escherichia coli."
    Brickman T.J., Ozenberger B.A., McIntosh M.A.
    J. Mol. Biol. 212:669-682(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-57.
  6. "Escherichia coli periplasmic protein FepB binds ferrienterobactin."
    Stephens D.L., Choe M.D., Earhart C.F.
    Microbiology 141:1647-1654(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiFEPB_ECOLI
AccessioniPrimary (citable) accession number: P0AEL6
Secondary accession number(s): P14609, Q2MBK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3