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P0AEL6

- FEPB_ECOLI

UniProt

P0AEL6 - FEPB_ECOLI

Protein

Ferrienterobactin-binding periplasmic protein

Gene

fepB

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Binds ferrienterobactin; part of the binding-protein-dependent transport system for uptake of ferrienterobactin.

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: EcoliWiki
    2. ion transport Source: UniProtKB-KW
    3. iron ion homeostasis Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Iron transport, Transport

    Keywords - Ligandi

    Iron

    Enzyme and pathway databases

    BioCyciEcoCyc:FEPB-MONOMER.
    ECOL316407:JW0584-MONOMER.
    MetaCyc:FEPB-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferrienterobactin-binding periplasmic protein
    Gene namesi
    Name:fepB
    Ordered Locus Names:b0592, JW0584
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG10294. fepB.

    Subcellular locationi

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 318292Ferrienterobactin-binding periplasmic proteinPRO_0000031821Add
    BLAST

    Proteomic databases

    PaxDbiP0AEL6.
    PRIDEiP0AEL6.

    Expressioni

    Inductioni

    Controlled in part by the amount of available iron.

    Gene expression databases

    GenevestigatoriP0AEL6.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-9593N.
    IntActiP0AEL6. 14 interactions.
    STRINGi511145.b0592.

    Structurei

    Secondary structure

    1
    318
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi30 – 356
    Beta strandi38 – 425
    Beta strandi47 – 526
    Helixi54 – 629
    Beta strandi67 – 726
    Turni77 – 793
    Helixi87 – 893
    Helixi90 – 956
    Beta strandi99 – 1057
    Helixi108 – 1125
    Beta strandi117 – 1259
    Helixi130 – 1323
    Helixi133 – 1375
    Beta strandi142 – 1454
    Beta strandi148 – 1503
    Helixi152 – 16312
    Helixi166 – 18621
    Beta strandi191 – 20010
    Turni201 – 2044
    Beta strandi205 – 2095
    Beta strandi211 – 2133
    Helixi214 – 2218
    Helixi233 – 2364
    Beta strandi243 – 2486
    Helixi252 – 2565
    Beta strandi259 – 2646
    Helixi269 – 2779
    Helixi279 – 2813
    Helixi285 – 2884
    Beta strandi292 – 2943
    Helixi297 – 2993
    Helixi304 – 31815

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2M6KNMR-A27-318[»]
    2M6LNMR-A27-318[»]
    3TLKX-ray1.85A/B/C1-318[»]
    ProteinModelPortaliP0AEL6.
    SMRiP0AEL6. Positions 27-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 318271Fe/B12 periplasmic-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Fe/B12 periplasmic-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4592.
    HOGENOMiHOG000117867.
    KOiK02016.
    OMAiWTAESAQ.
    OrthoDBiEOG61CM39.
    PhylomeDBiP0AEL6.

    Family and domain databases

    InterProiIPR002491. ABC_transptr_periplasmic_BD.
    [Graphical view]
    PfamiPF01497. Peripla_BP_2. 1 hit.
    [Graphical view]
    PROSITEiPS50983. FE_B12_PBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0AEL6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLAPLYRNA LLLTGLLLSG IAAVQAADWP RQITDSRGTH TLESQPQRIV    50
    STSVTLTGSL LAIDAPVIAS GATTPNNRVA DDQGFLRQWS KVAKERKLQR 100
    LYIGEPSAEA VAAQMPDLIL ISATGGDSAL ALYDQLSTIA PTLIINYDDK 150
    SWQSLLTQLG EITGHEKQAA ERIAQFDKQL AAAKEQIKLP PQPVTAIVYT 200
    AAAHSANLWT PESAQGQMLE QLGFTLAKLP AGLNASQSQG KRHDIIQLGG 250
    ENLAAGLNGE SLFLFAGDQK DADAIYANPL LAHLPAVQNK QVYALGTETF 300
    RLDYYSAMQV LDRLKALF 318
    Length:318
    Mass (Da):34,283
    Last modified:December 20, 2005 - v1
    Checksum:i807676D03A508079
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29730 Genomic DNA. Translation: AAA83853.1.
    U82598 Genomic DNA. Translation: AAB40791.1.
    U00096 Genomic DNA. Translation: AAC73693.1.
    AP009048 Genomic DNA. Translation: BAE76347.1.
    X53274 Genomic DNA. Translation: CAA37370.1.
    PIRiJV0045.
    RefSeqiNP_415124.1. NC_000913.3.
    YP_488881.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC73693; AAC73693; b0592.
    BAE76347; BAE76347; BAE76347.
    GeneIDi12931986.
    947538.
    KEGGiecj:Y75_p0581.
    eco:b0592.
    PATRICi32116360. VBIEscCol129921_0620.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29730 Genomic DNA. Translation: AAA83853.1 .
    U82598 Genomic DNA. Translation: AAB40791.1 .
    U00096 Genomic DNA. Translation: AAC73693.1 .
    AP009048 Genomic DNA. Translation: BAE76347.1 .
    X53274 Genomic DNA. Translation: CAA37370.1 .
    PIRi JV0045.
    RefSeqi NP_415124.1. NC_000913.3.
    YP_488881.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2M6K NMR - A 27-318 [» ]
    2M6L NMR - A 27-318 [» ]
    3TLK X-ray 1.85 A/B/C 1-318 [» ]
    ProteinModelPortali P0AEL6.
    SMRi P0AEL6. Positions 27-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-9593N.
    IntActi P0AEL6. 14 interactions.
    STRINGi 511145.b0592.

    Proteomic databases

    PaxDbi P0AEL6.
    PRIDEi P0AEL6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC73693 ; AAC73693 ; b0592 .
    BAE76347 ; BAE76347 ; BAE76347 .
    GeneIDi 12931986.
    947538.
    KEGGi ecj:Y75_p0581.
    eco:b0592.
    PATRICi 32116360. VBIEscCol129921_0620.

    Organism-specific databases

    EchoBASEi EB0290.
    EcoGenei EG10294. fepB.

    Phylogenomic databases

    eggNOGi COG4592.
    HOGENOMi HOG000117867.
    KOi K02016.
    OMAi WTAESAQ.
    OrthoDBi EOG61CM39.
    PhylomeDBi P0AEL6.

    Enzyme and pathway databases

    BioCyci EcoCyc:FEPB-MONOMER.
    ECOL316407:JW0584-MONOMER.
    MetaCyc:FEPB-MONOMER.

    Miscellaneous databases

    PROi P0AEL6.

    Gene expression databases

    Genevestigatori P0AEL6.

    Family and domain databases

    InterProi IPR002491. ABC_transptr_periplasmic_BD.
    [Graphical view ]
    Pfami PF01497. Peripla_BP_2. 1 hit.
    [Graphical view ]
    PROSITEi PS50983. FE_B12_PBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and regulation of the Escherichia coli gene for ferrienterobactin transport protein FepB."
      Elkins M.F., Earhart C.F.
      J. Bacteriol. 171:5443-5451(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12.
    2. "Sequence of minutes 4-25 of Escherichia coli."
      Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    5. "Regulation of divergent transcription from the iron-responsive fepB-entC promoter-operator regions in Escherichia coli."
      Brickman T.J., Ozenberger B.A., McIntosh M.A.
      J. Mol. Biol. 212:669-682(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-57.
    6. "Escherichia coli periplasmic protein FepB binds ferrienterobactin."
      Stephens D.L., Choe M.D., Earhart C.F.
      Microbiology 141:1647-1654(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiFEPB_ECOLI
    AccessioniPrimary (citable) accession number: P0AEL6
    Secondary accession number(s): P14609, Q2MBK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3