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Protein

Ferrienterobactin-binding periplasmic protein

Gene

fepB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds ferrienterobactin; part of the binding-protein-dependent transport system for uptake of ferrienterobactin.

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • ion transport Source: UniProtKB-KW
  • iron ion homeostasis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciEcoCyc:FEPB-MONOMER.
ECOL316407:JW0584-MONOMER.
MetaCyc:FEPB-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferrienterobactin-binding periplasmic protein
Gene namesi
Name:fepB
Ordered Locus Names:b0592, JW0584
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10294. fepB.

Subcellular locationi

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • outer membrane-bounded periplasmic space Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003182127 – 318Ferrienterobactin-binding periplasmic proteinAdd BLAST292

Proteomic databases

EPDiP0AEL6.
PaxDbiP0AEL6.
PRIDEiP0AEL6.

Expressioni

Inductioni

Controlled in part by the amount of available iron. Induced by hydroxyurea (PubMed:20005847).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260980. 351 interactors.
DIPiDIP-9593N.
IntActiP0AEL6. 14 interactors.
STRINGi511145.b0592.

Structurei

Secondary structure

1318
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 35Combined sources6
Beta strandi38 – 42Combined sources5
Beta strandi47 – 52Combined sources6
Helixi54 – 62Combined sources9
Beta strandi67 – 72Combined sources6
Turni77 – 79Combined sources3
Helixi87 – 89Combined sources3
Helixi90 – 95Combined sources6
Beta strandi99 – 105Combined sources7
Helixi108 – 112Combined sources5
Beta strandi117 – 125Combined sources9
Helixi130 – 132Combined sources3
Helixi133 – 137Combined sources5
Beta strandi142 – 145Combined sources4
Beta strandi148 – 150Combined sources3
Helixi152 – 163Combined sources12
Helixi166 – 186Combined sources21
Beta strandi191 – 200Combined sources10
Turni201 – 204Combined sources4
Beta strandi205 – 209Combined sources5
Beta strandi211 – 213Combined sources3
Helixi214 – 221Combined sources8
Helixi233 – 236Combined sources4
Beta strandi243 – 248Combined sources6
Helixi252 – 256Combined sources5
Beta strandi259 – 264Combined sources6
Helixi269 – 277Combined sources9
Helixi279 – 281Combined sources3
Helixi285 – 288Combined sources4
Beta strandi292 – 294Combined sources3
Helixi297 – 299Combined sources3
Helixi304 – 318Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M6KNMR-A27-318[»]
2M6LNMR-A27-318[»]
3TLKX-ray1.85A/B/C1-318[»]
ProteinModelPortaliP0AEL6.
SMRiP0AEL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 318Fe/B12 periplasmic-bindingPROSITE-ProRule annotationAdd BLAST271

Sequence similaritiesi

Contains 1 Fe/B12 periplasmic-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105PEC. Bacteria.
COG4592. LUCA.
HOGENOMiHOG000117867.
InParanoidiP0AEL6.
KOiK02016.
OMAiEIAPTIM.
PhylomeDBiP0AEL6.

Family and domain databases

InterProiIPR002491. ABC_transptr_periplasmic_BD.
[Graphical view]
PfamiPF01497. Peripla_BP_2. 1 hit.
[Graphical view]
PROSITEiPS50983. FE_B12_PBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AEL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLAPLYRNA LLLTGLLLSG IAAVQAADWP RQITDSRGTH TLESQPQRIV
60 70 80 90 100
STSVTLTGSL LAIDAPVIAS GATTPNNRVA DDQGFLRQWS KVAKERKLQR
110 120 130 140 150
LYIGEPSAEA VAAQMPDLIL ISATGGDSAL ALYDQLSTIA PTLIINYDDK
160 170 180 190 200
SWQSLLTQLG EITGHEKQAA ERIAQFDKQL AAAKEQIKLP PQPVTAIVYT
210 220 230 240 250
AAAHSANLWT PESAQGQMLE QLGFTLAKLP AGLNASQSQG KRHDIIQLGG
260 270 280 290 300
ENLAAGLNGE SLFLFAGDQK DADAIYANPL LAHLPAVQNK QVYALGTETF
310
RLDYYSAMQV LDRLKALF
Length:318
Mass (Da):34,283
Last modified:December 20, 2005 - v1
Checksum:i807676D03A508079
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29730 Genomic DNA. Translation: AAA83853.1.
U82598 Genomic DNA. Translation: AAB40791.1.
U00096 Genomic DNA. Translation: AAC73693.1.
AP009048 Genomic DNA. Translation: BAE76347.1.
X53274 Genomic DNA. Translation: CAA37370.1.
PIRiJV0045.
RefSeqiNP_415124.1. NC_000913.3.
WP_001234311.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73693; AAC73693; b0592.
BAE76347; BAE76347; BAE76347.
GeneIDi947538.
KEGGiecj:JW0584.
eco:b0592.
PATRICi32116360. VBIEscCol129921_0620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29730 Genomic DNA. Translation: AAA83853.1.
U82598 Genomic DNA. Translation: AAB40791.1.
U00096 Genomic DNA. Translation: AAC73693.1.
AP009048 Genomic DNA. Translation: BAE76347.1.
X53274 Genomic DNA. Translation: CAA37370.1.
PIRiJV0045.
RefSeqiNP_415124.1. NC_000913.3.
WP_001234311.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M6KNMR-A27-318[»]
2M6LNMR-A27-318[»]
3TLKX-ray1.85A/B/C1-318[»]
ProteinModelPortaliP0AEL6.
SMRiP0AEL6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260980. 351 interactors.
DIPiDIP-9593N.
IntActiP0AEL6. 14 interactors.
STRINGi511145.b0592.

Proteomic databases

EPDiP0AEL6.
PaxDbiP0AEL6.
PRIDEiP0AEL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73693; AAC73693; b0592.
BAE76347; BAE76347; BAE76347.
GeneIDi947538.
KEGGiecj:JW0584.
eco:b0592.
PATRICi32116360. VBIEscCol129921_0620.

Organism-specific databases

EchoBASEiEB0290.
EcoGeneiEG10294. fepB.

Phylogenomic databases

eggNOGiENOG4105PEC. Bacteria.
COG4592. LUCA.
HOGENOMiHOG000117867.
InParanoidiP0AEL6.
KOiK02016.
OMAiEIAPTIM.
PhylomeDBiP0AEL6.

Enzyme and pathway databases

BioCyciEcoCyc:FEPB-MONOMER.
ECOL316407:JW0584-MONOMER.
MetaCyc:FEPB-MONOMER.

Miscellaneous databases

PROiP0AEL6.

Family and domain databases

InterProiIPR002491. ABC_transptr_periplasmic_BD.
[Graphical view]
PfamiPF01497. Peripla_BP_2. 1 hit.
[Graphical view]
PROSITEiPS50983. FE_B12_PBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFEPB_ECOLI
AccessioniPrimary (citable) accession number: P0AEL6
Secondary accession number(s): P14609, Q2MBK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.