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P0AEL6 (FEPB_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrienterobactin-binding periplasmic protein
Gene names
Name:fepB
Ordered Locus Names:b0592, JW0584
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds ferrienterobactin; part of the binding-protein-dependent transport system for uptake of ferrienterobactin.

Subcellular location

Periplasm.

Induction

Controlled in part by the amount of available iron.

Sequence similarities

Belongs to the bacterial solute-binding protein 8 family.

Contains 1 Fe/B12 periplasmic-binding domain.

Ontologies

Keywords
   Biological processIon transport
Iron transport
Transport
   Cellular componentPeriplasm
   DomainSignal
   LigandIron
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to DNA damage stimulus

Inferred from expression pattern PubMed 11967071. Source: EcoliWiki

ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperiplasmic space

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 318292Ferrienterobactin-binding periplasmic protein
PRO_0000031821

Regions

Domain48 – 318271Fe/B12 periplasmic-binding

Secondary structure

...................................................... 318
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0AEL6 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 807676D03A508079

FASTA31834,283
        10         20         30         40         50         60 
MRLAPLYRNA LLLTGLLLSG IAAVQAADWP RQITDSRGTH TLESQPQRIV STSVTLTGSL 

        70         80         90        100        110        120 
LAIDAPVIAS GATTPNNRVA DDQGFLRQWS KVAKERKLQR LYIGEPSAEA VAAQMPDLIL 

       130        140        150        160        170        180 
ISATGGDSAL ALYDQLSTIA PTLIINYDDK SWQSLLTQLG EITGHEKQAA ERIAQFDKQL 

       190        200        210        220        230        240 
AAAKEQIKLP PQPVTAIVYT AAAHSANLWT PESAQGQMLE QLGFTLAKLP AGLNASQSQG 

       250        260        270        280        290        300 
KRHDIIQLGG ENLAAGLNGE SLFLFAGDQK DADAIYANPL LAHLPAVQNK QVYALGTETF 

       310 
RLDYYSAMQV LDRLKALF 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence and regulation of the Escherichia coli gene for ferrienterobactin transport protein FepB."
Elkins M.F., Earhart C.F.
J. Bacteriol. 171:5443-5451(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"Sequence of minutes 4-25 of Escherichia coli."
Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"Regulation of divergent transcription from the iron-responsive fepB-entC promoter-operator regions in Escherichia coli."
Brickman T.J., Ozenberger B.A., McIntosh M.A.
J. Mol. Biol. 212:669-682(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-57.
[6]"Escherichia coli periplasmic protein FepB binds ferrienterobactin."
Stephens D.L., Choe M.D., Earhart C.F.
Microbiology 141:1647-1654(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M29730 Genomic DNA. Translation: AAA83853.1.
U82598 Genomic DNA. Translation: AAB40791.1.
U00096 Genomic DNA. Translation: AAC73693.1.
AP009048 Genomic DNA. Translation: BAE76347.1.
X53274 Genomic DNA. Translation: CAA37370.1.
PIRJV0045.
RefSeqNP_415124.1. NC_000913.3.
YP_488881.1. NC_007779.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2M6KNMR-A27-318[»]
2M6LNMR-A27-318[»]
3TLKX-ray1.85A/B/C1-318[»]
ProteinModelPortalP0AEL6.
SMRP0AEL6. Positions 27-318.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-9593N.
IntActP0AEL6. 14 interactions.
STRING511145.b0592.

Proteomic databases

PaxDbP0AEL6.
PRIDEP0AEL6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC73693; AAC73693; b0592.
BAE76347; BAE76347; BAE76347.
GeneID12931986.
947538.
KEGGecj:Y75_p0581.
eco:b0592.
PATRIC32116360. VBIEscCol129921_0620.

Organism-specific databases

EchoBASEEB0290.
EcoGeneEG10294. fepB.

Phylogenomic databases

eggNOGCOG4592.
HOGENOMHOG000117867.
KOK02016.
OMAWTAESAQ.
OrthoDBEOG61CM39.
PhylomeDBP0AEL6.

Enzyme and pathway databases

BioCycEcoCyc:FEPB-MONOMER.
ECOL316407:JW0584-MONOMER.
MetaCyc:FEPB-MONOMER.

Gene expression databases

GenevestigatorP0AEL6.

Family and domain databases

InterProIPR002491. ABC_transptr_periplasmic_BD.
[Graphical view]
PfamPF01497. Peripla_BP_2. 1 hit.
[Graphical view]
PROSITEPS50983. FE_B12_PBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP0AEL6.

Entry information

Entry nameFEPB_ECOLI
AccessionPrimary (citable) accession number: P0AEL6
Secondary accession number(s): P14609, Q2MBK9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene