ID FEOA_ECOLI Reviewed; 75 AA. AC P0AEL3; P33649; Q2M773; DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot. DT 20-DEC-2005, sequence version 1. DT 24-JAN-2024, entry version 117. DE RecName: Full=Fe(2+) transport protein A {ECO:0000305}; DE AltName: Full=Ferrous iron transport protein A; GN Name=feoA; OrderedLocusNames=b3408, JW3371; OS Escherichia coli (strain K12). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=83333; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE. RC STRAIN=K12 / MC4100; RX PubMed=8407793; DOI=10.1128/jb.175.19.6212-6219.1993; RA Kammler M., Schoen C., Hantke K.; RT "Characterization of the ferrous iron uptake system of Escherichia coli."; RL J. Bacteriol. 175:6212-6219(1993). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., RA Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1462(1997). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=16738553; DOI=10.1038/msb4100049; RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 RT and W3110."; RL Mol. Syst. Biol. 2:E1-E5(2006). RN [4] RP INDUCTION BY HYDROXYUREA. RC STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574; RX PubMed=20005847; DOI=10.1016/j.molcel.2009.11.024; RA Davies B.W., Kohanski M.A., Simmons L.A., Winkler J.A., Collins J.J., RA Walker G.C.; RT "Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia RT coli."; RL Mol. Cell 36:845-860(2009). RN [5] {ECO:0007744|PDB:2LX9} RP STRUCTURE BY NMR, SUBUNIT, AND SUBCELLULAR LOCATION. RC STRAIN=K12; RX PubMed=23104801; DOI=10.1128/jb.01121-12; RA Lau C.K., Ishida H., Liu Z., Vogel H.J.; RT "Solution structure of Escherichia coli FeoA and its potential role in RT bacterial ferrous iron transport."; RL J. Bacteriol. 195:46-55(2013). CC -!- FUNCTION: Involved in Fe(2+) ion uptake (PubMed:8407793). Does not CC stimulate the GTPase activity of the N-terminus of FeoB (residues 1- CC 276). {ECO:0000269|PubMed:23104801, ECO:0000269|PubMed:8407793}. CC -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:23104801}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:23104801}. CC -!- INDUCTION: Induced by hydroxyurea (PubMed:20005847). CC {ECO:0000269|PubMed:20005847}. CC -!- DISRUPTION PHENOTYPE: Reduced uptake of Fe(2+). CC {ECO:0000269|PubMed:8407793}. CC -!- SIMILARITY: Belongs to the FeoA family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X71063; CAA50386.1; -; Genomic_DNA. DR EMBL; U18997; AAA58206.1; -; Genomic_DNA. DR EMBL; U00096; AAC76433.1; -; Genomic_DNA. DR EMBL; AP009048; BAE77883.1; -; Genomic_DNA. DR PIR; B36932; B36932. DR RefSeq; NP_417867.1; NC_000913.3. DR RefSeq; WP_001200455.1; NZ_SSZK01000008.1. DR PDB; 2LX9; NMR; -; A=1-75. DR PDBsum; 2LX9; -. DR AlphaFoldDB; P0AEL3; -. DR BMRB; P0AEL3; -. DR SMR; P0AEL3; -. DR BioGRID; 4261724; 9. DR BioGRID; 852218; 2. DR IntAct; P0AEL3; 4. DR STRING; 511145.b3408; -. DR TCDB; 9.A.8.1.1; the ferrous iron uptake (feob) family. DR PaxDb; 511145-b3408; -. DR EnsemblBacteria; AAC76433; AAC76433; b3408. DR GeneID; 83578378; -. DR GeneID; 947909; -. DR KEGG; ecj:JW3371; -. DR KEGG; eco:b3408; -. DR PATRIC; fig|1411691.4.peg.3321; -. DR EchoBASE; EB2025; -. DR eggNOG; COG1918; Bacteria. DR HOGENOM; CLU_150646_13_0_6; -. DR InParanoid; P0AEL3; -. DR OMA; MGDPVQI; -. DR OrthoDB; 9811076at2; -. DR PhylomeDB; P0AEL3; -. DR BioCyc; EcoCyc:EG12101-MONOMER; -. DR EvolutionaryTrace; P0AEL3; -. DR PRO; PR:P0AEL3; -. DR Proteomes; UP000000318; Chromosome. DR Proteomes; UP000000625; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro. DR GO; GO:0006974; P:DNA damage response; IEP:EcoliWiki. DR GO; GO:0006826; P:iron ion transport; IEA:UniProtKB-KW. DR Gene3D; 2.30.30.90; -; 1. DR InterPro; IPR007167; Fe-transptr_FeoA. DR InterPro; IPR038157; FeoA_core_dom. DR InterPro; IPR008988; Transcriptional_repressor_C. DR PANTHER; PTHR42954; FE(2+) TRANSPORT PROTEIN A; 1. DR PANTHER; PTHR42954:SF2; FE(2+) TRANSPORT PROTEIN A; 1. DR Pfam; PF04023; FeoA; 1. DR SMART; SM00899; FeoA; 1. DR SUPFAM; SSF50037; C-terminal domain of transcriptional repressors; 1. PE 1: Evidence at protein level; KW 3D-structure; Cytoplasm; Ion transport; Iron; Iron transport; KW Reference proteome; Transport. FT CHAIN 1..75 FT /note="Fe(2+) transport protein A" FT /id="PRO_0000087222" FT STRAND 8..13 FT /evidence="ECO:0007829|PDB:2LX9" FT STRAND 16..18 FT /evidence="ECO:0007829|PDB:2LX9" FT HELIX 20..28 FT /evidence="ECO:0007829|PDB:2LX9" FT STRAND 33..42 FT /evidence="ECO:0007829|PDB:2LX9" FT TURN 44..46 FT /evidence="ECO:0007829|PDB:2LX9" FT STRAND 49..52 FT /evidence="ECO:0007829|PDB:2LX9" FT STRAND 57..60 FT /evidence="ECO:0007829|PDB:2LX9" FT HELIX 62..67 FT /evidence="ECO:0007829|PDB:2LX9" FT STRAND 68..72 FT /evidence="ECO:0007829|PDB:2LX9" SQ SEQUENCE 75 AA; 8371 MW; 945AC2E01C24CC92 CRC64; MQYTPDTAWK ITGFSREISP AYRQKLLSLG MLPGSSFNVV RVAPLGDPIH IETRRVSLVL RKKDLALLEV EAVSC //