P0AEL3 (FEOA_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferrous iron transport protein A

Gene names

Name:	feoA
Ordered Locus Names:	b3408, JW3371

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	75 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

Not known. Involved in Fe2+ ion uptake.

Ontologies

Keywords
Biological process	Ion transport Iron transport Transport
Ligand	Iron
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ferrous iron import Inferred from mutant phenotype Ref.1. Source: EcoCyc iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW response to DNA damage stimulus Inferred from expression pattern PubMed 11967071. Source: EcoliWiki
Molecular_function	transition metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 75

75

Ferrous iron transport protein A

PRO_0000087222

Secondary structure

1

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75

Helix Strand Turn

Details...

Beta strand

7 – 12

6

Beta strand

16 – 18

3

Helix

20 – 26

7

Turn

27 – 29

3

Beta strand

33 – 39

7

Turn

44 – 46

3

Beta strand

48 – 53

6

Beta strand

56 – 61

6

Turn

62 – 67

6

Beta strand

68 – 72

5

Sequences

	Sequence		Length	Mass (Da)
	P0AEL3 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 945AC2E01C24CC92	FASTA	75	8,371
	10 20 30 40 50 60 MQYTPDTAWK ITGFSREISP AYRQKLLSLG MLPGSSFNVV RVAPLGDPIH IETRRVSLVL 70 RKKDLALLEV EAVSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the ferrous iron uptake system of Escherichia coli." Kammler M., Schoen C., Hantke K. J. Bacteriol. 175:6212-6219(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X71063 Genomic DNA. Translation: CAA50386.1.
U18997 Genomic DNA. Translation: AAA58206.1.
U00096 Genomic DNA. Translation: AAC76433.1.
AP009048 Genomic DNA. Translation: BAE77883.1.

PIR

B36932.

RefSeq

NP_417867.1. NC_000913.2.
YP_492024.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2GCX	NMR	-	A	1-73	[»]
2LX9	NMR	-	A	1-74	[»]

ProteinModelPortal

P0AEL3.

SMR

P0AEL3. Positions 1-74.

ModBase

Search...

Protein-protein interaction databases

IntAct

P0AEL3. 2 interactions.

STRING

511145.b3408.

Proteomic databases

PaxDb

P0AEL3.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAC76433; AAC76433; b3408.
BAE77883; BAE77883; BAE77883.

GeneID

12932730.
947909.

KEGG

ecj:Y75_p3768.
eco:b3408.

PATRIC

32122252. VBIEscCol129921_3503.

Organism-specific databases

EchoBASE

EB2025.

EcoGene

EG12101. feoA.

Phylogenomic databases

eggNOG

COG1918.

HOGENOM

HOG000053908.

KO

K04758.

OMA

ALLNIEP.

ProtClustDB

PRK09555.

Enzyme and pathway databases

BioCyc

EcoCyc:EG12101-MONOMER.
ECOL316407:JW3371-MONOMER.

Gene expression databases

Genevestigator

P0AEL3.

Family and domain databases

InterPro

IPR007167. Fe-transptr_FeoA.
[Graphical view]

Pfam

PF04023. FeoA. 1 hit.
[Graphical view]

SMART

SM00899. FeoA. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P0AEL3.

Entry information

Entry name

FEOA_ECOLI

Accession

Primary (citable) accession number: P0AEL3
Secondary accession number(s): P33649, Q2M773

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program