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Protein

Ferrous iron transport protein A

Gene

feoA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Not known. Involved in Fe2+ ion uptake.

GO - Molecular functioni

  1. transition metal ion binding Source: InterPro

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: EcoliWiki
  2. ferrous iron import Source: EcoCyc
  3. iron ion homeostasis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciEcoCyc:EG12101-MONOMER.
ECOL316407:JW3371-MONOMER.

Protein family/group databases

TCDBi9.A.8.1.1. the ferrous iron uptake (feob) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferrous iron transport protein A
Gene namesi
Name:feoA
Ordered Locus Names:b3408, JW3371
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12101. feoA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7575Ferrous iron transport protein APRO_0000087222Add
BLAST

Proteomic databases

PaxDbiP0AEL3.

Expressioni

Gene expression databases

GenevestigatoriP0AEL3.

Interactioni

Protein-protein interaction databases

IntActiP0AEL3. 4 interactions.
STRINGi511145.b3408.

Structurei

Secondary structure

1
75
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 136Combined sources
Beta strandi16 – 183Combined sources
Helixi20 – 289Combined sources
Beta strandi33 – 4210Combined sources
Turni44 – 463Combined sources
Beta strandi49 – 524Combined sources
Beta strandi57 – 604Combined sources
Helixi62 – 676Combined sources
Beta strandi68 – 725Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GCXNMR-A1-73[»]
2LX9NMR-A1-75[»]
ProteinModelPortaliP0AEL3.
SMRiP0AEL3. Positions 1-74.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AEL3.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1918.
HOGENOMiHOG000053908.
InParanoidiP0AEL3.
KOiK04758.
OMAiIETRRVN.
OrthoDBiEOG6J48SS.
PhylomeDBiP0AEL3.

Family and domain databases

InterProiIPR007167. Fe-transptr_FeoA.
IPR008988. Transcriptional_repressor_C.
[Graphical view]
PfamiPF04023. FeoA. 1 hit.
[Graphical view]
SMARTiSM00899. FeoA. 1 hit.
[Graphical view]
SUPFAMiSSF50037. SSF50037. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AEL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQYTPDTAWK ITGFSREISP AYRQKLLSLG MLPGSSFNVV RVAPLGDPIH
60 70
IETRRVSLVL RKKDLALLEV EAVSC
Length:75
Mass (Da):8,371
Last modified:December 20, 2005 - v1
Checksum:i945AC2E01C24CC92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71063 Genomic DNA. Translation: CAA50386.1.
U18997 Genomic DNA. Translation: AAA58206.1.
U00096 Genomic DNA. Translation: AAC76433.1.
AP009048 Genomic DNA. Translation: BAE77883.1.
PIRiB36932.
RefSeqiNP_417867.1. NC_000913.3.
YP_492024.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC76433; AAC76433; b3408.
BAE77883; BAE77883; BAE77883.
GeneIDi12932730.
947909.
KEGGiecj:Y75_p3768.
eco:b3408.
PATRICi32122252. VBIEscCol129921_3503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71063 Genomic DNA. Translation: CAA50386.1.
U18997 Genomic DNA. Translation: AAA58206.1.
U00096 Genomic DNA. Translation: AAC76433.1.
AP009048 Genomic DNA. Translation: BAE77883.1.
PIRiB36932.
RefSeqiNP_417867.1. NC_000913.3.
YP_492024.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GCXNMR-A1-73[»]
2LX9NMR-A1-75[»]
ProteinModelPortaliP0AEL3.
SMRiP0AEL3. Positions 1-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0AEL3. 4 interactions.
STRINGi511145.b3408.

Protein family/group databases

TCDBi9.A.8.1.1. the ferrous iron uptake (feob) family.

Proteomic databases

PaxDbiP0AEL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76433; AAC76433; b3408.
BAE77883; BAE77883; BAE77883.
GeneIDi12932730.
947909.
KEGGiecj:Y75_p3768.
eco:b3408.
PATRICi32122252. VBIEscCol129921_3503.

Organism-specific databases

EchoBASEiEB2025.
EcoGeneiEG12101. feoA.

Phylogenomic databases

eggNOGiCOG1918.
HOGENOMiHOG000053908.
InParanoidiP0AEL3.
KOiK04758.
OMAiIETRRVN.
OrthoDBiEOG6J48SS.
PhylomeDBiP0AEL3.

Enzyme and pathway databases

BioCyciEcoCyc:EG12101-MONOMER.
ECOL316407:JW3371-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0AEL3.
PROiP0AEL3.

Gene expression databases

GenevestigatoriP0AEL3.

Family and domain databases

InterProiIPR007167. Fe-transptr_FeoA.
IPR008988. Transcriptional_repressor_C.
[Graphical view]
PfamiPF04023. FeoA. 1 hit.
[Graphical view]
SMARTiSM00899. FeoA. 1 hit.
[Graphical view]
SUPFAMiSSF50037. SSF50037. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the ferrous iron uptake system of Escherichia coli."
    Kammler M., Schoen C., Hantke K.
    J. Bacteriol. 175:6212-6219(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiFEOA_ECOLI
AccessioniPrimary (citable) accession number: P0AEL3
Secondary accession number(s): P33649, Q2M773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: January 7, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.