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Protein

Exodeoxyribonuclease 10

Gene

exoX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Capable of degrading both single-strand and double-strand DNA with 3' to 5' polarity. Has higher affinity for ssDNA ends than for dsDNA.

Cofactori

GO - Molecular functioni

  • 3'-5' exonuclease activity Source: EcoCyc
  • nucleic acid binding Source: InterPro

GO - Biological processi

  • mismatch repair Source: EcoCyc
  • nucleic acid phosphodiester bond hydrolysis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciEcoCyc:G7016-MONOMER.
ECOL316407:JW1833-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 10 (EC:3.1.11.-)
Alternative name(s):
Exodeoxyribonuclease X
Short name:
Exo X
Short name:
Exonuclease X
Gene namesi
Name:exoX
Synonyms:yobC
Ordered Locus Names:b1844, JW1833
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14031. exoX.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Exodeoxyribonuclease 10PRO_0000087136Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi511145.b1844.

Structurei

Secondary structure

1
220
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 1110Combined sources
Beta strandi16 – 2510Combined sources
Beta strandi28 – 369Combined sources
Helixi45 – 517Combined sources
Helixi55 – 584Combined sources
Helixi64 – 674Combined sources
Helixi68 – 714Combined sources
Beta strandi75 – 817Combined sources
Helixi82 – 887Combined sources
Beta strandi93 – 986Combined sources
Helixi99 – 1068Combined sources
Helixi114 – 1207Combined sources
Helixi136 – 15419Combined sources
Helixi158 – 1658Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FZXX-ray2.30C/D1-167[»]
4FZYX-ray2.50A/B1-167[»]
4FZZX-ray2.80A/B1-167[»]
ProteinModelPortaliP0AEK0.
SMRiP0AEK0. Positions 1-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0847.
HOGENOMiHOG000121240.
InParanoidiP0AEK0.
KOiK10857.
OMAiMAIHKIT.
OrthoDBiEOG696BTR.
PhylomeDBiP0AEK0.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AEK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRIIDTETC GLQGGIVEIA SVDVIDGKIV NPMSHLVRPD RPISPQAMAI
60 70 80 90 100
HRITEAMVAD KPWIEDVIPH YYGSEWYVAH NASFDRRVLP EMPGEWICTM
110 120 130 140 150
KLARRLWPGI KYSNMALYKT RKLNVQTPPG LHHHRALYDC YITAALLIDI
160 170 180 190 200
MNTSGWTAEQ MADITGRPSL MTTFTFGKYR GKAVSDVAER DPGYLRWLFN
210 220
NLDSMSPELR LTLKHYLENT
Length:220
Mass (Da):25,133
Last modified:December 20, 2005 - v1
Checksum:iA1863A22C8C57A6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194116 Genomic DNA. Translation: AAF04847.1.
U00096 Genomic DNA. Translation: AAC74914.1.
AP009048 Genomic DNA. Translation: BAE76547.1.
PIRiD64946.
RefSeqiNP_416358.1. NC_000913.3.
WP_000944256.1. NZ_CP010445.1.

Genome annotation databases

EnsemblBacteriaiAAC74914; AAC74914; b1844.
BAE76547; BAE76547; BAE76547.
GeneIDi946361.
KEGGieco:b1844.
PATRICi32119009. VBIEscCol129921_1922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194116 Genomic DNA. Translation: AAF04847.1.
U00096 Genomic DNA. Translation: AAC74914.1.
AP009048 Genomic DNA. Translation: BAE76547.1.
PIRiD64946.
RefSeqiNP_416358.1. NC_000913.3.
WP_000944256.1. NZ_CP010445.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FZXX-ray2.30C/D1-167[»]
4FZYX-ray2.50A/B1-167[»]
4FZZX-ray2.80A/B1-167[»]
ProteinModelPortaliP0AEK0.
SMRiP0AEK0. Positions 1-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511145.b1844.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74914; AAC74914; b1844.
BAE76547; BAE76547; BAE76547.
GeneIDi946361.
KEGGieco:b1844.
PATRICi32119009. VBIEscCol129921_1922.

Organism-specific databases

EchoBASEiEB3785.
EcoGeneiEG14031. exoX.

Phylogenomic databases

eggNOGiCOG0847.
HOGENOMiHOG000121240.
InParanoidiP0AEK0.
KOiK10857.
OMAiMAIHKIT.
OrthoDBiEOG696BTR.
PhylomeDBiP0AEK0.

Enzyme and pathway databases

BioCyciEcoCyc:G7016-MONOMER.
ECOL316407:JW1833-MONOMER.

Miscellaneous databases

PROiP0AEK0.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Exonuclease X of Escherichia coli. A novel 3'-5' DNase and DnaQ superfamily member involved in DNA repair."
    Viswanathan M., Lovett S.T.
    J. Biol. Chem. 274:30094-30100(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiEXOX_ECOLI
AccessioniPrimary (citable) accession number: P0AEK0
Secondary accession number(s): P76281, Q2MB09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: July 22, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.