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P0AEK0 (EXOX_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exodeoxyribonuclease 10

EC=3.1.11.-
Alternative name(s):
Exodeoxyribonuclease X
Short name=Exo X
Short name=Exonuclease X
Gene names
Name:exoX
Synonyms:yobC
Ordered Locus Names:b1844, JW1833
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Capable of degrading both single-strand and double-strand DNA with 3' to 5' polarity. Has higher affinity for ssDNA ends than for dsDNA.

Cofactor

Magnesium.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Exodeoxyribonuclease 10
PRO_0000087136

Secondary structure

.......................... 220
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0AEK0 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: A1863A22C8C57A6F

FASTA22025,133
        10         20         30         40         50         60 
MLRIIDTETC GLQGGIVEIA SVDVIDGKIV NPMSHLVRPD RPISPQAMAI HRITEAMVAD 

        70         80         90        100        110        120 
KPWIEDVIPH YYGSEWYVAH NASFDRRVLP EMPGEWICTM KLARRLWPGI KYSNMALYKT 

       130        140        150        160        170        180 
RKLNVQTPPG LHHHRALYDC YITAALLIDI MNTSGWTAEQ MADITGRPSL MTTFTFGKYR 

       190        200        210        220 
GKAVSDVAER DPGYLRWLFN NLDSMSPELR LTLKHYLENT 

« Hide

References

« Hide 'large scale' references
[1]"Exonuclease X of Escherichia coli. A novel 3'-5' DNase and DnaQ superfamily member involved in DNA repair."
Viswanathan M., Lovett S.T.
J. Biol. Chem. 274:30094-30100(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF194116 Genomic DNA. Translation: AAF04847.1.
U00096 Genomic DNA. Translation: AAC74914.1.
AP009048 Genomic DNA. Translation: BAE76547.1.
PIRD64946.
RefSeqNP_416358.1. NC_000913.3.
YP_490106.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4FZXX-ray2.30C/D1-167[»]
4FZYX-ray2.50A/B1-167[»]
4FZZX-ray2.80A/B1-167[»]
ProteinModelPortalP0AEK0.
SMRP0AEK0. Positions 1-167.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING511145.b1844.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC74914; AAC74914; b1844.
BAE76547; BAE76547; BAE76547.
GeneID12931369.
946361.
KEGGecj:Y75_p1820.
eco:b1844.
PATRIC32119009. VBIEscCol129921_1922.

Organism-specific databases

EchoBASEEB3785.
EcoGeneEG14031. exoX.

Phylogenomic databases

eggNOGCOG0847.
HOGENOMHOG000121240.
KOK10857.
OMAPGYLRWM.
OrthoDBEOG696BTR.
PhylomeDBP0AEK0.
ProtClustDBPRK07983.

Enzyme and pathway databases

BioCycEcoCyc:G7016-MONOMER.
ECOL316407:JW1833-MONOMER.

Gene expression databases

GenevestigatorP0AEK0.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
InterProIPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMSSF53098. SSF53098. 1 hit.
ProtoNetSearch...

Other

PROP0AEK0.

Entry information

Entry nameEXOX_ECOLI
AccessionPrimary (citable) accession number: P0AEK0
Secondary accession number(s): P76281, Q2MB09
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene