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P0AEK0

- EXOX_ECOLI

UniProt

P0AEK0 - EXOX_ECOLI

Protein

Exodeoxyribonuclease 10

Gene

exoX

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (11 Jun 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Capable of degrading both single-strand and double-strand DNA with 3' to 5' polarity. Has higher affinity for ssDNA ends than for dsDNA.

    Cofactori

    Magnesium.

    GO - Molecular functioni

    1. 3'-5' exonuclease activity Source: EcoCyc
    2. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. mismatch repair Source: EcoCyc
    2. nucleic acid phosphodiester bond hydrolysis Source: GOC

    Keywords - Molecular functioni

    Exonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    BioCyciEcoCyc:G7016-MONOMER.
    ECOL316407:JW1833-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exodeoxyribonuclease 10 (EC:3.1.11.-)
    Alternative name(s):
    Exodeoxyribonuclease X
    Short name:
    Exo X
    Short name:
    Exonuclease X
    Gene namesi
    Name:exoX
    Synonyms:yobC
    Ordered Locus Names:b1844, JW1833
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG14031. exoX.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220Exodeoxyribonuclease 10PRO_0000087136Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP0AEK0.

    Interactioni

    Protein-protein interaction databases

    STRINGi511145.b1844.

    Structurei

    Secondary structure

    1
    220
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 1110
    Beta strandi16 – 2510
    Beta strandi28 – 369
    Helixi45 – 517
    Helixi55 – 584
    Helixi64 – 674
    Helixi68 – 714
    Beta strandi75 – 817
    Helixi82 – 887
    Beta strandi93 – 986
    Helixi99 – 1068
    Helixi114 – 1207
    Helixi136 – 15419
    Helixi158 – 1658

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4FZXX-ray2.30C/D1-167[»]
    4FZYX-ray2.50A/B1-167[»]
    4FZZX-ray2.80A/B1-167[»]
    ProteinModelPortaliP0AEK0.
    SMRiP0AEK0. Positions 1-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0847.
    HOGENOMiHOG000121240.
    KOiK10857.
    OMAiMVEGKPR.
    OrthoDBiEOG696BTR.
    PhylomeDBiP0AEK0.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    InterProiIPR006055. Exonuclease.
    IPR013520. Exonuclease_RNaseT/DNA_pol3.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PfamiPF00929. RNase_T. 1 hit.
    [Graphical view]
    SMARTiSM00479. EXOIII. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0AEK0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRIIDTETC GLQGGIVEIA SVDVIDGKIV NPMSHLVRPD RPISPQAMAI    50
    HRITEAMVAD KPWIEDVIPH YYGSEWYVAH NASFDRRVLP EMPGEWICTM 100
    KLARRLWPGI KYSNMALYKT RKLNVQTPPG LHHHRALYDC YITAALLIDI 150
    MNTSGWTAEQ MADITGRPSL MTTFTFGKYR GKAVSDVAER DPGYLRWLFN 200
    NLDSMSPELR LTLKHYLENT 220
    Length:220
    Mass (Da):25,133
    Last modified:December 20, 2005 - v1
    Checksum:iA1863A22C8C57A6F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF194116 Genomic DNA. Translation: AAF04847.1.
    U00096 Genomic DNA. Translation: AAC74914.1.
    AP009048 Genomic DNA. Translation: BAE76547.1.
    PIRiD64946.
    RefSeqiNP_416358.1. NC_000913.3.
    YP_490106.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC74914; AAC74914; b1844.
    BAE76547; BAE76547; BAE76547.
    GeneIDi12931369.
    946361.
    KEGGiecj:Y75_p1820.
    eco:b1844.
    PATRICi32119009. VBIEscCol129921_1922.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF194116 Genomic DNA. Translation: AAF04847.1 .
    U00096 Genomic DNA. Translation: AAC74914.1 .
    AP009048 Genomic DNA. Translation: BAE76547.1 .
    PIRi D64946.
    RefSeqi NP_416358.1. NC_000913.3.
    YP_490106.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4FZX X-ray 2.30 C/D 1-167 [» ]
    4FZY X-ray 2.50 A/B 1-167 [» ]
    4FZZ X-ray 2.80 A/B 1-167 [» ]
    ProteinModelPortali P0AEK0.
    SMRi P0AEK0. Positions 1-166.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 511145.b1844.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC74914 ; AAC74914 ; b1844 .
    BAE76547 ; BAE76547 ; BAE76547 .
    GeneIDi 12931369.
    946361.
    KEGGi ecj:Y75_p1820.
    eco:b1844.
    PATRICi 32119009. VBIEscCol129921_1922.

    Organism-specific databases

    EchoBASEi EB3785.
    EcoGenei EG14031. exoX.

    Phylogenomic databases

    eggNOGi COG0847.
    HOGENOMi HOG000121240.
    KOi K10857.
    OMAi MVEGKPR.
    OrthoDBi EOG696BTR.
    PhylomeDBi P0AEK0.

    Enzyme and pathway databases

    BioCyci EcoCyc:G7016-MONOMER.
    ECOL316407:JW1833-MONOMER.

    Miscellaneous databases

    PROi P0AEK0.

    Gene expression databases

    Genevestigatori P0AEK0.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    InterProi IPR006055. Exonuclease.
    IPR013520. Exonuclease_RNaseT/DNA_pol3.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    Pfami PF00929. RNase_T. 1 hit.
    [Graphical view ]
    SMARTi SM00479. EXOIII. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Exonuclease X of Escherichia coli. A novel 3'-5' DNase and DnaQ superfamily member involved in DNA repair."
      Viswanathan M., Lovett S.T.
      J. Biol. Chem. 274:30094-30100(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiEXOX_ECOLI
    AccessioniPrimary (citable) accession number: P0AEK0
    Secondary accession number(s): P76281, Q2MB09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 20, 2005
    Last modified: June 11, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3