Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Exodeoxyribonuclease 10

Gene

exoX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Capable of degrading both single-strand and double-strand DNA with 3' to 5' polarity. Has higher affinity for ssDNA ends than for dsDNA.

Cofactori

GO - Molecular functioni

  • 3'-5' exonuclease activity Source: EcoCyc
  • nucleic acid binding Source: InterPro

GO - Biological processi

  • mismatch repair Source: EcoCyc

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandMagnesium

Enzyme and pathway databases

BioCyciEcoCyc:G7016-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 10 (EC:3.1.11.-)
Alternative name(s):
Exodeoxyribonuclease X
Short name:
Exo X
Short name:
Exonuclease X
Gene namesi
Name:exoX
Synonyms:yobC
Ordered Locus Names:b1844, JW1833
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14031 exoX

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000871361 – 220Exodeoxyribonuclease 10Add BLAST220

Proteomic databases

PaxDbiP0AEK0
PRIDEiP0AEK0

Interactioni

Protein-protein interaction databases

BioGridi4260363, 106 interactors
STRINGi316385.ECDH10B_1985

Structurei

Secondary structure

1220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 11Combined sources10
Beta strandi16 – 25Combined sources10
Beta strandi28 – 36Combined sources9
Helixi45 – 51Combined sources7
Helixi55 – 58Combined sources4
Helixi64 – 67Combined sources4
Helixi68 – 71Combined sources4
Beta strandi75 – 81Combined sources7
Helixi82 – 88Combined sources7
Beta strandi93 – 98Combined sources6
Helixi99 – 106Combined sources8
Helixi114 – 120Combined sources7
Helixi136 – 154Combined sources19
Helixi158 – 165Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FZXX-ray2.30C/D1-167[»]
4FZYX-ray2.50A/B1-167[»]
4FZZX-ray2.80A/B1-167[»]
ProteinModelPortaliP0AEK0
SMRiP0AEK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105UMD Bacteria
COG0847 LUCA
HOGENOMiHOG000121240
InParanoidiP0AEK0
KOiK10857
OMAiYYVAHNA
PhylomeDBiP0AEK0

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00929 RNase_T, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

P0AEK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRIIDTETC GLQGGIVEIA SVDVIDGKIV NPMSHLVRPD RPISPQAMAI
60 70 80 90 100
HRITEAMVAD KPWIEDVIPH YYGSEWYVAH NASFDRRVLP EMPGEWICTM
110 120 130 140 150
KLARRLWPGI KYSNMALYKT RKLNVQTPPG LHHHRALYDC YITAALLIDI
160 170 180 190 200
MNTSGWTAEQ MADITGRPSL MTTFTFGKYR GKAVSDVAER DPGYLRWLFN
210 220
NLDSMSPELR LTLKHYLENT
Length:220
Mass (Da):25,133
Last modified:December 20, 2005 - v1
Checksum:iA1863A22C8C57A6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194116 Genomic DNA Translation: AAF04847.1
U00096 Genomic DNA Translation: AAC74914.1
AP009048 Genomic DNA Translation: BAE76547.1
PIRiD64946
RefSeqiNP_416358.1, NC_000913.3
WP_000944256.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74914; AAC74914; b1844
BAE76547; BAE76547; BAE76547
GeneIDi946361
KEGGiecj:JW1833
eco:b1844
PATRICifig|511145.12.peg.1922

Similar proteinsi

Entry informationi

Entry nameiEXOX_ECOLI
AccessioniPrimary (citable) accession number: P0AEK0
Secondary accession number(s): P76281, Q2MB09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health