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P0AEK0

- EXOX_ECOLI

UniProt

P0AEK0 - EXOX_ECOLI

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Protein
Exodeoxyribonuclease 10
Gene
exoX, yobC, b1844, JW1833
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Capable of degrading both single-strand and double-strand DNA with 3' to 5' polarity. Has higher affinity for ssDNA ends than for dsDNA.

Cofactori

Magnesium.

GO - Molecular functioni

  1. 3'-5' exonuclease activity Source: EcoCyc
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. mismatch repair Source: EcoCyc
  2. nucleic acid phosphodiester bond hydrolysis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciEcoCyc:G7016-MONOMER.
ECOL316407:JW1833-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 10 (EC:3.1.11.-)
Alternative name(s):
Exodeoxyribonuclease X
Short name:
Exo X
Short name:
Exonuclease X
Gene namesi
Name:exoX
Synonyms:yobC
Ordered Locus Names:b1844, JW1833
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG14031. exoX.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Exodeoxyribonuclease 10
PRO_0000087136Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP0AEK0.

Interactioni

Protein-protein interaction databases

STRINGi511145.b1844.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 1110
Beta strandi16 – 2510
Beta strandi28 – 369
Helixi45 – 517
Helixi55 – 584
Helixi64 – 674
Helixi68 – 714
Beta strandi75 – 817
Helixi82 – 887
Beta strandi93 – 986
Helixi99 – 1068
Helixi114 – 1207
Helixi136 – 15419
Helixi158 – 1658

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FZXX-ray2.30C/D1-167[»]
4FZYX-ray2.50A/B1-167[»]
4FZZX-ray2.80A/B1-167[»]
ProteinModelPortaliP0AEK0.
SMRiP0AEK0. Positions 1-166.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0847.
HOGENOMiHOG000121240.
KOiK10857.
OMAiMVEGKPR.
OrthoDBiEOG696BTR.
PhylomeDBiP0AEK0.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AEK0-1 [UniParc]FASTAAdd to Basket

« Hide

MLRIIDTETC GLQGGIVEIA SVDVIDGKIV NPMSHLVRPD RPISPQAMAI    50
HRITEAMVAD KPWIEDVIPH YYGSEWYVAH NASFDRRVLP EMPGEWICTM 100
KLARRLWPGI KYSNMALYKT RKLNVQTPPG LHHHRALYDC YITAALLIDI 150
MNTSGWTAEQ MADITGRPSL MTTFTFGKYR GKAVSDVAER DPGYLRWLFN 200
NLDSMSPELR LTLKHYLENT 220
Length:220
Mass (Da):25,133
Last modified:December 20, 2005 - v1
Checksum:iA1863A22C8C57A6F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF194116 Genomic DNA. Translation: AAF04847.1.
U00096 Genomic DNA. Translation: AAC74914.1.
AP009048 Genomic DNA. Translation: BAE76547.1.
PIRiD64946.
RefSeqiNP_416358.1. NC_000913.3.
YP_490106.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74914; AAC74914; b1844.
BAE76547; BAE76547; BAE76547.
GeneIDi12931369.
946361.
KEGGiecj:Y75_p1820.
eco:b1844.
PATRICi32119009. VBIEscCol129921_1922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF194116 Genomic DNA. Translation: AAF04847.1 .
U00096 Genomic DNA. Translation: AAC74914.1 .
AP009048 Genomic DNA. Translation: BAE76547.1 .
PIRi D64946.
RefSeqi NP_416358.1. NC_000913.3.
YP_490106.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4FZX X-ray 2.30 C/D 1-167 [» ]
4FZY X-ray 2.50 A/B 1-167 [» ]
4FZZ X-ray 2.80 A/B 1-167 [» ]
ProteinModelPortali P0AEK0.
SMRi P0AEK0. Positions 1-166.
ModBasei Search...

Protein-protein interaction databases

STRINGi 511145.b1844.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74914 ; AAC74914 ; b1844 .
BAE76547 ; BAE76547 ; BAE76547 .
GeneIDi 12931369.
946361.
KEGGi ecj:Y75_p1820.
eco:b1844.
PATRICi 32119009. VBIEscCol129921_1922.

Organism-specific databases

EchoBASEi EB3785.
EcoGenei EG14031. exoX.

Phylogenomic databases

eggNOGi COG0847.
HOGENOMi HOG000121240.
KOi K10857.
OMAi MVEGKPR.
OrthoDBi EOG696BTR.
PhylomeDBi P0AEK0.

Enzyme and pathway databases

BioCyci EcoCyc:G7016-MONOMER.
ECOL316407:JW1833-MONOMER.

Miscellaneous databases

PROi P0AEK0.

Gene expression databases

Genevestigatori P0AEK0.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
InterProi IPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF00929. RNase_T. 1 hit.
[Graphical view ]
SMARTi SM00479. EXOIII. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Exonuclease X of Escherichia coli. A novel 3'-5' DNase and DnaQ superfamily member involved in DNA repair."
    Viswanathan M., Lovett S.T.
    J. Biol. Chem. 274:30094-30100(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiEXOX_ECOLI
AccessioniPrimary (citable) accession number: P0AEK0
Secondary accession number(s): P76281, Q2MB09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

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