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Reviewed, UniProtKB/Swiss-Prot P0AEJ6 (EUTB_ECOLI)

Last modified June 16, 2009. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ethanolamine ammonia-lyase heavy chain
    EC=4.3.1.7
Alternative name(s):
    Ethanolamine ammonia-lyase large subunit
Gene names
Name: eutB
Ordered Locus Names: b2441, JW2434
OrganismEscherichia coli (strain K12) [Complete proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

Ethanolamine = acetaldehyde + NH3.

Cofactor

Adenosylcobalamin.

Pathway

Amine and polyamine degradation; ethanolamine degradation.

Subunit structure

Heterodimer of two non-identical chains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

groLP0A6F51EBI-1128853,EBI-543750

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Ethanolamine ammonia-lyase heavy chain
PRO_0000087081

Sequences

Sequence LengthMass (Da)Tools
P0AEJ6-1 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 21C14FC469716060

FASTA45349,403
        10         20         30         40         50         60 
MKLKTTLFGN VYQFKDVKEV LAKANELRSG DVLAGVAAAS SQERVAAKQV LSEMTVADIR 

        70         80         90        100        110        120 
NNPVIAYEDD CVTRLIQDDV NETAYNQIKN WSISELREYV LSDETSVDDI AFTRKGLTSE 

       130        140        150        160        170        180 
VVAAVAKICS NADLIYGAKK MPVIKKANTT IGIPGTFSAR LQPNDTRDDV QSIAAQIYEG 

       190        200        210        220        230        240 
LSFGVGDAVI GVNPVTDDVE NLSRVLDTIY GVIDKFNIPT QGCVLAHVTT QIEAIRRGAP 

       250        260        270        280        290        300 
GGLIFQSICG SEKGLKEFGV ELAMLDEARA VGAEFNRIAG ENCLYFETGQ GSALSAGANF 

       310        320        330        340        350        360 
GADQVTMEAR NYGLARHYDP FIVNTVVGFI GPEYLYNDRQ IIRAGLEDHF MGKLSGISMG 

       370        380        390        400        410        420 
CDCCYTNHAD ADQNLNENLM ILLATAGCNY IMGMPLGDDI MLNYQTTAFH DTATVRQLLN 

       430        440        450 
LRPSPEFERW LESMGIMANG RLTKRAGDPS LFF 

« Hide

References

« Hide 'large scale' references
[1]"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T. expand/collapse author list , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
DNA Res. 4:91-113(1997) [PubMed: 9205837] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Cloning, sequencing, and expression of the genes encoding the adenosylcobalamin-dependent ethanolamine ammonia-lyase of Salmonella typhimurium."
Faust L.R.P., Connor J.A., Roof D.M., Hoch J.A., Babior B.M.
J. Biol. Chem. 265:12462-12466(1990) [PubMed: 2197274] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-30.

Cross-references

Sequence databases

U00096 Genomic DNA. Translation: AAC75494.1. Different initiation.
AP009048 Genomic DNA. Translation: BAA16323.1.
PIRH65018.
RefSeqAP_003035.1.
NP_416936.4.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActP0AEJ6. 1 interaction.

Genome annotation databases

GeneID946924.
GenomeReviewsGene locus JW2434 in contig AP009048_GR.
Gene locus b2441 in contig U00096_GR.
KEGGecj:JW2434.
eco:b2441.

Organism-specific databases

EchoBASEEB4299.
EcoGeneEG50006. eutB.
CMRSearch...

Phylogenomic databases

HOGENOMP0AEJ6.
OMAP0AEJ6. EARCYGL.

Enzyme and pathway databases

BioCycEcoCyc:EUTB-MON.
MetaCyc:EUTB-MON.

Family and domain databases

InterProIPR010628. EutB.
[Graphical view]
PfamPF06751. EutB. 1 hit.
[Graphical view]
PIRSFPIRSF018788. EutB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameEUTB_ECOLI
AccessionPrimary (citable) accession number: P0AEJ6
Secondary accession number(s): P19635, P78094, P78300
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: June 16, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PATHWAY comments

Index of metabolic and biosynthesis pathways

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents