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Protein

Ethanolamine ammonia-lyase heavy chain

Gene

eutB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Ethanolamine = acetaldehyde + NH3.

Cofactori

Pathwayi: ethanolamine degradation

This protein is involved in the pathway ethanolamine degradation, which is part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the pathway ethanolamine degradation and in Amine and polyamine degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Cobalt

Enzyme and pathway databases

BioCyciEcoCyc:EUTB-MONOMER.
ECOL316407:JW2434-MONOMER.
MetaCyc:EUTB-MONOMER.
UniPathwayiUPA00560.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethanolamine ammonia-lyase heavy chain (EC:4.3.1.7)
Alternative name(s):
Ethanolamine ammonia-lyase large subunit
Gene namesi
Name:eutB
Ordered Locus Names:b2441, JW2434
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG50006. eutB.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • ethanolamine ammonia-lyase complex Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Ethanolamine ammonia-lyase heavy chainPRO_0000087081Add
BLAST

Proteomic databases

PaxDbiP0AEJ6.
PRIDEiP0AEJ6.

Interactioni

Subunit structurei

Heterodimer of two non-identical chains.

Protein-protein interaction databases

BioGridi4260578. 8 interactions.
IntActiP0AEJ6. 1 interaction.
STRINGi511145.b2441.

Structurei

Secondary structure

1
453
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 74Combined sources
Beta strandi10 – 134Combined sources
Helixi17 – 237Combined sources
Helixi29 – 335Combined sources
Helixi41 – 5313Combined sources
Helixi56 – 605Combined sources
Helixi67 – 693Combined sources
Helixi71 – 788Combined sources
Helixi82 – 887Combined sources
Helixi93 – 1019Combined sources
Helixi107 – 1137Combined sources
Helixi114 – 1163Combined sources
Helixi119 – 1279Combined sources
Helixi131 – 1399Combined sources
Beta strandi145 – 1517Combined sources
Beta strandi158 – 1614Combined sources
Helixi170 – 18112Combined sources
Turni182 – 1843Combined sources
Beta strandi190 – 1923Combined sources
Helixi199 – 21517Combined sources
Beta strandi222 – 2243Combined sources
Helixi228 – 2369Combined sources
Beta strandi244 – 2474Combined sources
Helixi252 – 2587Combined sources
Helixi262 – 27514Combined sources
Beta strandi279 – 2813Combined sources
Beta strandi284 – 2885Combined sources
Helixi292 – 2954Combined sources
Helixi304 – 31613Combined sources
Beta strandi321 – 3266Combined sources
Turni332 – 3343Combined sources
Helixi338 – 35417Combined sources
Beta strandi359 – 3624Combined sources
Helixi373 – 38513Combined sources
Beta strandi390 – 3945Combined sources
Helixi395 – 3973Combined sources
Turni400 – 4034Combined sources
Helixi409 – 41911Combined sources
Helixi425 – 4339Combined sources
Beta strandi436 – 4383Combined sources
Helixi449 – 4524Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ABOX-ray2.10A/C1-453[»]
3ABQX-ray2.05A/C1-453[»]
3ABRX-ray2.10A/C1-453[»]
3ABSX-ray2.25A/C1-453[»]
3ANYX-ray2.10A/C1-453[»]
3AO0X-ray2.25A/C1-453[»]
ProteinModelPortaliP0AEJ6.
SMRiP0AEJ6. Positions 1-453.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AEJ6.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105CPD. Bacteria.
COG4303. LUCA.
HOGENOMiHOG000288958.
InParanoidiP0AEJ6.
KOiK03735.
OMAiSIPTQGC.
PhylomeDBiP0AEJ6.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR010628. EutB.
[Graphical view]
PfamiPF06751. EutB. 1 hit.
[Graphical view]
PIRSFiPIRSF018788. EutB. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AEJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLKTTLFGN VYQFKDVKEV LAKANELRSG DVLAGVAAAS SQERVAAKQV
60 70 80 90 100
LSEMTVADIR NNPVIAYEDD CVTRLIQDDV NETAYNQIKN WSISELREYV
110 120 130 140 150
LSDETSVDDI AFTRKGLTSE VVAAVAKICS NADLIYGAKK MPVIKKANTT
160 170 180 190 200
IGIPGTFSAR LQPNDTRDDV QSIAAQIYEG LSFGVGDAVI GVNPVTDDVE
210 220 230 240 250
NLSRVLDTIY GVIDKFNIPT QGCVLAHVTT QIEAIRRGAP GGLIFQSICG
260 270 280 290 300
SEKGLKEFGV ELAMLDEARA VGAEFNRIAG ENCLYFETGQ GSALSAGANF
310 320 330 340 350
GADQVTMEAR NYGLARHYDP FIVNTVVGFI GPEYLYNDRQ IIRAGLEDHF
360 370 380 390 400
MGKLSGISMG CDCCYTNHAD ADQNLNENLM ILLATAGCNY IMGMPLGDDI
410 420 430 440 450
MLNYQTTAFH DTATVRQLLN LRPSPEFERW LESMGIMANG RLTKRAGDPS

LFF
Length:453
Mass (Da):49,403
Last modified:December 20, 2005 - v1
Checksum:i21C14FC469716060
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75494.2.
AP009048 Genomic DNA. Translation: BAA16323.1.
PIRiH65018.
RefSeqiNP_416936.4. NC_000913.3.
WP_000769961.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75494; AAC75494; b2441.
BAA16323; BAA16323; BAA16323.
GeneIDi946924.
KEGGiecj:JW2434.
eco:b2441.
PATRICi32120267. VBIEscCol129921_2536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75494.2.
AP009048 Genomic DNA. Translation: BAA16323.1.
PIRiH65018.
RefSeqiNP_416936.4. NC_000913.3.
WP_000769961.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ABOX-ray2.10A/C1-453[»]
3ABQX-ray2.05A/C1-453[»]
3ABRX-ray2.10A/C1-453[»]
3ABSX-ray2.25A/C1-453[»]
3ANYX-ray2.10A/C1-453[»]
3AO0X-ray2.25A/C1-453[»]
ProteinModelPortaliP0AEJ6.
SMRiP0AEJ6. Positions 1-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260578. 8 interactions.
IntActiP0AEJ6. 1 interaction.
STRINGi511145.b2441.

Proteomic databases

PaxDbiP0AEJ6.
PRIDEiP0AEJ6.

Protocols and materials databases

DNASUi946924.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75494; AAC75494; b2441.
BAA16323; BAA16323; BAA16323.
GeneIDi946924.
KEGGiecj:JW2434.
eco:b2441.
PATRICi32120267. VBIEscCol129921_2536.

Organism-specific databases

EchoBASEiEB4299.
EcoGeneiEG50006. eutB.

Phylogenomic databases

eggNOGiENOG4105CPD. Bacteria.
COG4303. LUCA.
HOGENOMiHOG000288958.
InParanoidiP0AEJ6.
KOiK03735.
OMAiSIPTQGC.
PhylomeDBiP0AEJ6.

Enzyme and pathway databases

UniPathwayiUPA00560.
BioCyciEcoCyc:EUTB-MONOMER.
ECOL316407:JW2434-MONOMER.
MetaCyc:EUTB-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0AEJ6.
PROiP0AEJ6.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR010628. EutB.
[Graphical view]
PfamiPF06751. EutB. 1 hit.
[Graphical view]
PIRSFiPIRSF018788. EutB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEUTB_ECOLI
AccessioniPrimary (citable) accession number: P0AEJ6
Secondary accession number(s): P19635, P78094, P78300
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.