P0AEH5 (ELAB_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein ElaB

Gene names

Name:	elaB
Synonyms:	yfbD
Ordered Locus Names:	b2266, JW2261

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Upon overexpression binds to ribosomes.
Subcellular location	Cell inner membrane; Single-pass membrane protein Potential.
Induction	Maximally expressed between 6 and 12 hours of growth, in early stationary phase. Ref.8
Sequence similarities	Belongs to the ElaB/YgaM/YqjD family.
Sequence caution	The sequence Z50849 differs from that shown. Reason: Frameshift at position 73.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to DNA damage stimulus Inferred from expression pattern PubMed 11967071. Source: EcoliWiki
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 101	101	Protein ElaB		PRO_0000086947
Regions
	Transmembrane	80 – 99	20	Helical; Potential
Amino acid modifications
	Modified residue	35	1	N6-acetyllysine Ref.7

Sequences

	Sequence		Length	Mass (Da)
	P0AEH5 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: B934E815C373CF6F	FASTA	101	11,306
	10 20 30 40 50 60 MSNQFGDTRI DDDLTLLSET LEEVLRSSGD PADQKYVELK ARAEKALDDV KKRVSQASDS 70 80 90 100 YYYRAKQAVY RADDYVHEKP WQGIGVGAAV GLVLGLLLAR R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An isochorismate hydroxymutase isogene in Escherichia coli." Mueller R., Dahm C., Schulte G., Leistner E. FEBS Lett. 378:131-134(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.
[2]	"Characterization of the ela locus from Escherichia coli." Huisman G.W. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[3]	"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T. , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T. DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[5]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]	Rudd K.E. Unpublished observations (MAR-1996) Cited for: IDENTIFICATION.
[7]	"Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli." Zhang J., Sprung R., Pei J., Tan X., Kim S., Zhu H., Liu C.F., Grishin N.V., Zhao Y. Mol. Cell. Proteomics 8:215-225(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-35, MASS SPECTROMETRY. Strain: K12 / JW1106 and K12 / MG1655 / ATCC 47076.
[8]	"YqjD is an inner membrane protein associated with stationary-phase ribosomes in Escherichia coli." Yoshida H., Maki Y., Furuike S., Sakai A., Ueta M., Wada A. J. Bacteriol. 194:4178-4183(2012) [PubMed] [Europe PMC] [Abstract] Cited for: RIBOSOME-BINDING, INDUCTION. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z50849 Genomic DNA. No translation available. U58768 Genomic DNA. Translation: AAB02730.1. U00096 Genomic DNA. Translation: AAC75326.1. AP009048 Genomic DNA. Translation: BAA16093.1.
PIR	H64997.
RefSeq	NP_416769.1. NC_000913.2. YP_490506.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P0AEH5.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-47919N.
IntAct	P0AEH5. 10 interactions.
MINT	MINT-1311168.
STRING	511145.b2266.
Proteomic databases
PaxDb	P0AEH5.
PRIDE	P0AEH5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC75326; AAC75326; b2266. BAA16093; BAA16093; BAA16093.
GeneID	12931526. 946751.
KEGG	ecj:Y75_p2230. eco:b2266.
PATRIC	32119899. VBIEscCol129921_2359.
Organism-specific databases
EchoBASE	EB2977.
EcoGene	EG13185. elaB.
Phylogenomic databases
eggNOG	COG4575.
HOGENOM	HOG000256775.
KO	K05594.
OMA	ENPWQTI.
ProtClustDB	PRK10404.
Enzyme and pathway databases
BioCyc	EcoCyc:G7173-MONOMER. ECOL316407:JW2261-MONOMER.
Gene expression databases
Genevestigator	P0AEH5.
Family and domain databases
InterPro	IPR010279. DUF883_ElaB. [Graphical view]
Pfam	PF05957. DUF883. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ELAB_ECOLI

Accession

Primary (citable) accession number: P0AEH5
Secondary accession number(s): P52084, Q47010

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program