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Protein

Thiol:disulfide interchange protein DsbC

Gene

dsbC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a disulfide isomerase, interacting with incorrectly folded proteins to correct non-native disulfide bonds. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by DsbD.1 Publication

GO - Molecular functioni

  • protein disulfide isomerase activity Source: EcoCyc
  • protein disulfide oxidoreductase activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

BioCyciEcoCyc:DSBC-MONOMER
MetaCyc:DSBC-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol:disulfide interchange protein DsbC
Gene namesi
Name:dsbC
Synonyms:xprA
Ordered Locus Names:b2893, JW2861
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Organism-specific databases

EcoGeneiEG11070 dsbC

Subcellular locationi

  • Periplasm 1 Publication

GO - Cellular componenti

  • outer membrane-bounded periplasmic space Source: EcoCyc
  • periplasmic space Source: EcoliWiki

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi118C → T or A: Loss of activity. 1 Publication1
Mutagenesisi121C → A: Partial loss of activity. 1 Publication1
Mutagenesisi121C → V: Loss of activity. 1 Publication1
Mutagenesisi161C → S: Destabilization of protein. 1 Publication1
Mutagenesisi183C → L: Destabilization of protein. 1 Publication1

Chemistry databases

DrugBankiDB03814 2-(N-Morpholino)-Ethanesulfonic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000003427321 – 236Thiol:disulfide interchange protein DsbCAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi118 ↔ 121Redox-activePROSITE-ProRule annotation1 Publication
Disulfide bondi161 ↔ 1831 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0AEG6
PRIDEiP0AEG6

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi4261304, 500 interactors
DIPiDIP-35818N
IntActiP0AEG6, 9 interactors
STRINGi316385.ECDH10B_3067

Structurei

Secondary structure

1236
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi22 – 31Combined sources10
Beta strandi36 – 41Combined sources6
Beta strandi47 – 52Combined sources6
Beta strandi55 – 60Combined sources6
Beta strandi65 – 69Combined sources5
Beta strandi71 – 73Combined sources3
Beta strandi75 – 78Combined sources4
Helixi82 – 92Combined sources11
Helixi93 – 97Combined sources5
Beta strandi98 – 101Combined sources4
Beta strandi108 – 114Combined sources7
Helixi119 – 125Combined sources7
Helixi128 – 133Combined sources6
Beta strandi136 – 142Combined sources7
Beta strandi148 – 150Combined sources3
Helixi151 – 160Combined sources10
Beta strandi162 – 164Combined sources3
Helixi165 – 173Combined sources9
Helixi187 – 197Combined sources11
Beta strandi201 – 206Combined sources6
Beta strandi212 – 215Combined sources4
Helixi219 – 234Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EEJX-ray1.90A/B21-236[»]
1G0TX-ray2.60A/B21-236[»]
1JZDX-ray2.30A/B20-236[»]
1JZOX-ray1.92A/B21-236[»]
1TJDX-ray2.50A21-236[»]
2IYJX-ray2.00A/B19-91[»]
ProteinModelPortaliP0AEG6
SMRiP0AEG6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AEG6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 231ThioredoxinPROSITE-ProRule annotationAdd BLAST196

Sequence similaritiesi

Belongs to the thioredoxin family. DsbC subfamily.Curated

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiENOG4105T95 Bacteria
COG1651 LUCA
HOGENOMiHOG000222077
InParanoidiP0AEG6
KOiK03981
OMAiQMIVYKA
PhylomeDBiP0AEG6

Family and domain databases

CDDicd03020 DsbA_DsbC_DsbG, 1 hit
Gene3Di3.10.450.70, 1 hit
InterProiView protein in InterPro
IPR033954 DiS-bond_Isoase_DsbC/G
IPR018950 DiS-bond_isomerase_DsbC/G_N
IPR009094 DiS-bond_isomerase_DsbC/G_N_sf
IPR012336 Thioredoxin-like_fold
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF10411 DsbC_N, 1 hit
PF13098 Thioredoxin_2, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF54423 SSF54423, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AEG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKGFMLFTL LAAFSGFAQA DDAAIQQTLA KMGIKSSDIQ PAPVAGMKTV
60 70 80 90 100
LTNSGVLYIT DDGKHIIQGP MYDVSGTAPV NVTNKMLLKQ LNALEKEMIV
110 120 130 140 150
YKAPQEKHVI TVFTDITCGY CHKLHEQMAD YNALGITVRY LAFPRQGLDS
160 170 180 190 200
DAEKEMKAIW CAKDKNKAFD DVMAGKSVAP ASCDVDIADH YALGVQLGVS
210 220 230
GTPAVVLSNG TLVPGYQPPK EMKEFLDEHQ KMTSGK
Length:236
Mass (Da):25,622
Last modified:December 6, 2005 - v1
Checksum:i69A834A666BAA6D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219Missing in AAA62788 (PubMed:1987126).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M54884 Genomic DNA Translation: AAA62788.1
U28375 Genomic DNA Translation: AAA83074.1
U00096 Genomic DNA Translation: AAC75931.1
AP009048 Genomic DNA Translation: BAE76958.1
PIRiE65073
RefSeqiNP_417369.1, NC_000913.3
WP_000715214.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75931; AAC75931; b2893
BAE76958; BAE76958; BAE76958
GeneIDi947363
KEGGiecj:JW2861
eco:b2893
PATRICifig|1411691.4.peg.3840

Similar proteinsi

Entry informationi

Entry nameiDSBC_ECOLI
AccessioniPrimary (citable) accession number: P0AEG6
Secondary accession number(s): P21892, Q2M9U8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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