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P0AEG5 (DSBA_ECO57) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thiol:disulfide interchange protein DsbA
Gene names
Name:dsbA
Ordered Locus Names:Z5392, ECs4783
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis By similarity.

Subcellular location

Periplasm By similarity.

Sequence similarities

Belongs to the thioredoxin family. DsbA subfamily.

Contains 1 thioredoxin domain.

Ontologies

Keywords
   Cellular componentPeriplasm
   DomainRedox-active center
Signal
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular componentperiplasmic space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein disulfide oxidoreductase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 208189Thiol:disulfide interchange protein DsbA
PRO_0000043367

Regions

Domain20 – 150131Thioredoxin

Amino acid modifications

Disulfide bond49 ↔ 52Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
P0AEG5 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 10527E876FCAEE55

FASTA20823,105
        10         20         30         40         50         60 
MKKIWLALAG LVLAFSASAA QYEDGKQYTT LEKPVAGAPQ VLEFFSFFCP HCYQFEEVLH 

        70         80         90        100        110        120 
ISDNVKKKLP EGVKMTKYHV NFMGGDLGKD LTQAWAVAMA LGVEDKVTVP LFEGVQKTQT 

       130        140        150        160        170        180 
IRSASDIRDV FINAGIKGEE YDAAWNSFVV KSLVAQQEKA AADVQLRGVP AMFVNGKYQL 

       190        200 
NPQGMDTSNM DVFVQQYADT VKYLSEKK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005174 Genomic DNA. Translation: AAG59049.1.
BA000007 Genomic DNA. Translation: BAB38206.1.
PIRE86073.
G91226.
RefSeqNP_290485.1. NC_002655.2.
NP_312810.1. NC_002695.1.

3D structure databases

ProteinModelPortalP0AEG5.
SMRP0AEG5. Positions 20-207.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-1247926.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000027537; EBESCP00000026430; EBESCG00000026589.
EBESCT00000058235; EBESCP00000056063; EBESCG00000057283.
GeneID915115.
960300.
GenomeReviewsGene locus Z5392 in contig AE005174_GR.
Gene locus ECs4783 in contig BA000007_GR.
KEGGece:Z5392.
ecs:ECs4783.
PATRIC18359201. VBIEscCol44059_4750.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000010220.
HOGENOMHBG680642.
OMAMFEAVQK.
ProtClustDBPRK10954.

Enzyme and pathway databases

BioCycECOL83334:ECS4783-MONOMER.

Family and domain databases

InterProIPR001853. DSBA-like_thioredoxin_dom.
IPR023205. Thiol:disulphide_interchange.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 2 hits.
KOK03673.
PfamPF01323. DSBA. 1 hit.
[Graphical view]
PIRSFPIRSF001488. Tdi_protein. 1 hit.
SUPFAMSSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDSBA_ECO57
AccessionPrimary (citable) accession number: P0AEG5
Secondary accession number(s): P24991, Q46951, Q46952
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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