P0AEG1 (DPPC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dipeptide transport system permease protein DppC

Gene names

Name:	dppC
Ordered Locus Names:	b3542, JW3511

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane.
Subcellular location	Cell inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. Contains 1 ABC transmembrane type-1 domain.

Ontologies

Keywords
Biological process	Peptide transport Protein transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	ATP-binding cassette (ABC) transporter complex Inferred from sequence or structural similarity Ref.1. Source: EcoCyc integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	dipeptide transporter activity Inferred from genetic interaction PubMed 1702779. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 300	300	Dipeptide transport system permease protein DppC		PRO_0000060009
Regions
	Topological domain	1 – 31	31	Cytoplasmic Potential
	Transmembrane	32 – 52	21	Helical; Potential
	Topological domain	53 – 101	49	Periplasmic Potential
	Transmembrane	102 – 122	21	Helical; Potential
	Topological domain	123 – 136	14	Cytoplasmic Potential
	Transmembrane	137 – 157	21	Helical; Potential
	Topological domain	158 – 206	49	Periplasmic Potential
	Transmembrane	207 – 227	21	Helical; Potential
	Topological domain	228 – 230	3	Cytoplasmic Potential
	Transmembrane	231 – 251	21	Helical; Potential
	Topological domain	252 – 265	14	Periplasmic Potential
	Transmembrane	266 – 286	21	Helical; Potential
	Topological domain	287 – 300	14	Cytoplasmic Potential
	Domain	98 – 287	190	ABC transmembrane type-1

Sequences

	Sequence		Length	Mass (Da)
	P0AEG1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: C4DD7BD82286EE62	FASTA	300	32,308
	10 20 30 40 50 60 MSQVTENKVI SAPVPMTPLQ EFWHYFKRNK GAVVGLVYVV IVLFIAIFAN WIAPYNPAEQ 70 80 90 100 110 120 FRDALLAPPA WQEGGSMAHL LGTDDVGRDV LSRLMYGARL SLLVGCLVVV LSLIMGVILG 130 140 150 160 170 180 LIAGYFGGLV DNIIMRVVDI MLALPSLLLA LVLVAIFGPS IGNAALALTF VALPHYVRLT 190 200 210 220 230 240 RAAVLVEVNR DYVTASRVAG AGAMRQMFIN IFPNCLAPLI VQASLGFSNA ILDMAALGFL 250 260 270 280 290 300 GMGAQPPTPE WGTMLSDVLQ FAQSAWWVVT FPGLAILLTV LAFNLMGDGL RDALDPKLKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The dipeptide permease of Escherichia coli closely resembles other bacterial transport systems and shows growth-phase-dependent expression." Abouhamad W.N., Manson M.D. Mol. Microbiol. 14:1077-1092(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / MM500.
[2]	"Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes." Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R. Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Global topology analysis of the Escherichia coli inner membrane proteome." Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G. Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: K12 / MG1655 / ATCC 47076.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L08399 Genomic DNA. Translation: AAA23704.1. U00039 Genomic DNA. Translation: AAB18520.1. U00096 Genomic DNA. Translation: AAC76567.1. AP009048 Genomic DNA. Translation: BAE77752.1.
PIR	S47764.
RefSeq	NP_417999.1. NC_000913.2. YP_491893.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P0AEG1.
ModBase	Search...
Protein-protein interaction databases
IntAct	P0AEG1. 1 interaction.
MINT	MINT-1282303.
STRING	511145.b3542.
Proteomic databases
PRIDE	P0AEG1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC76567; AAC76567; b3542. BAE77752; BAE77752; BAE77752.
GeneID	12933190. 948064.
KEGG	ecj:Y75_p3634. eco:b3542.
PATRIC	32122552. VBIEscCol129921_3654.
Organism-specific databases
EchoBASE	EB2510.
EcoGene	EG12626. dppC.
Phylogenomic databases
eggNOG	COG1173.
HOGENOM	HOG000171368.
KO	K12370.
OMA	NPADQFR.
ProtClustDB	PRK10913.
Enzyme and pathway databases
BioCyc	EcoCyc:DPPC-MONOMER. ECOL316407:JW3511-MONOMER.
Gene expression databases
Genevestigator	P0AEG1.
Family and domain databases
InterPro	IPR000515. BPD_transp. IPR025966. OppC_N. [Graphical view]
Pfam	PF00528. BPD_transp_1. 1 hit. PF12911. OppC_N. 1 hit. [Graphical view]
PROSITE	PS50928. ABC_TM1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DPPC_ECOLI

Accession

Primary (citable) accession number: P0AEG1
Secondary accession number(s): P37315, Q2M7K4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program