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Protein

Dipeptide transport system permease protein DppC

Gene

dppC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:DPPC-MONOMER.
ECOL316407:JW3511-MONOMER.
MetaCyc:DPPC-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptide transport system permease protein DppC
Gene namesi
Name:dppC
Ordered Locus Names:b3542, JW3511
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12626. dppC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31CytoplasmicSequence analysisAdd BLAST31
Transmembranei32 – 52HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini53 – 101PeriplasmicSequence analysisAdd BLAST49
Transmembranei102 – 122HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini123 – 136CytoplasmicSequence analysisAdd BLAST14
Transmembranei137 – 157HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini158 – 206PeriplasmicSequence analysisAdd BLAST49
Transmembranei207 – 227HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini228 – 230CytoplasmicSequence analysis3
Transmembranei231 – 251HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini252 – 265PeriplasmicSequence analysisAdd BLAST14
Transmembranei266 – 286HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini287 – 300CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000600091 – 300Dipeptide transport system permease protein DppCAdd BLAST300

Proteomic databases

PaxDbiP0AEG1.
PRIDEiP0AEG1.

Interactioni

Protein-protein interaction databases

BioGridi4262184. 246 interactors.
DIPiDIP-9469N.
IntActiP0AEG1. 1 interactor.
MINTiMINT-1282303.
STRINGi511145.b3542.

Structurei

3D structure databases

ProteinModelPortaliP0AEG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 287ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST190

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C2T. Bacteria.
COG1173. LUCA.
HOGENOMiHOG000171368.
InParanoidiP0AEG1.
KOiK12370.
OMAiSVMSEKN.
PhylomeDBiP0AEG1.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
IPR025966. OppC_N.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
PF12911. OppC_N. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AEG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQVTENKVI SAPVPMTPLQ EFWHYFKRNK GAVVGLVYVV IVLFIAIFAN
60 70 80 90 100
WIAPYNPAEQ FRDALLAPPA WQEGGSMAHL LGTDDVGRDV LSRLMYGARL
110 120 130 140 150
SLLVGCLVVV LSLIMGVILG LIAGYFGGLV DNIIMRVVDI MLALPSLLLA
160 170 180 190 200
LVLVAIFGPS IGNAALALTF VALPHYVRLT RAAVLVEVNR DYVTASRVAG
210 220 230 240 250
AGAMRQMFIN IFPNCLAPLI VQASLGFSNA ILDMAALGFL GMGAQPPTPE
260 270 280 290 300
WGTMLSDVLQ FAQSAWWVVT FPGLAILLTV LAFNLMGDGL RDALDPKLKQ
Length:300
Mass (Da):32,308
Last modified:December 6, 2005 - v1
Checksum:iC4DD7BD82286EE62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08399 Genomic DNA. Translation: AAA23704.1.
U00039 Genomic DNA. Translation: AAB18520.1.
U00096 Genomic DNA. Translation: AAC76567.1.
AP009048 Genomic DNA. Translation: BAE77752.1.
PIRiS47764.
RefSeqiNP_417999.1. NC_000913.3.
WP_000084677.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76567; AAC76567; b3542.
BAE77752; BAE77752; BAE77752.
GeneIDi948064.
KEGGiecj:JW3511.
eco:b3542.
PATRICi32122552. VBIEscCol129921_3654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08399 Genomic DNA. Translation: AAA23704.1.
U00039 Genomic DNA. Translation: AAB18520.1.
U00096 Genomic DNA. Translation: AAC76567.1.
AP009048 Genomic DNA. Translation: BAE77752.1.
PIRiS47764.
RefSeqiNP_417999.1. NC_000913.3.
WP_000084677.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AEG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262184. 246 interactors.
DIPiDIP-9469N.
IntActiP0AEG1. 1 interactor.
MINTiMINT-1282303.
STRINGi511145.b3542.

Proteomic databases

PaxDbiP0AEG1.
PRIDEiP0AEG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76567; AAC76567; b3542.
BAE77752; BAE77752; BAE77752.
GeneIDi948064.
KEGGiecj:JW3511.
eco:b3542.
PATRICi32122552. VBIEscCol129921_3654.

Organism-specific databases

EchoBASEiEB2510.
EcoGeneiEG12626. dppC.

Phylogenomic databases

eggNOGiENOG4105C2T. Bacteria.
COG1173. LUCA.
HOGENOMiHOG000171368.
InParanoidiP0AEG1.
KOiK12370.
OMAiSVMSEKN.
PhylomeDBiP0AEG1.

Enzyme and pathway databases

BioCyciEcoCyc:DPPC-MONOMER.
ECOL316407:JW3511-MONOMER.
MetaCyc:DPPC-MONOMER.

Miscellaneous databases

PROiP0AEG1.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
IPR025966. OppC_N.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
PF12911. OppC_N. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPPC_ECOLI
AccessioniPrimary (citable) accession number: P0AEG1
Secondary accession number(s): P37315, Q2M7K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.