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Protein

Dipeptide transport system permease protein DppB

Gene

dppB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:DPPB-MONOMER.
ECOL316407:JW3512-MONOMER.
MetaCyc:DPPB-MONOMER.
RETL1328306-WGS:GSTH-2068-MONOMER.
RETL1328306-WGS:GSTH-4082-MONOMER.
RETL1328306-WGS:GSTH-4924-MONOMER.
RETL1328306-WGS:GSTH-749-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptide transport system permease protein DppB
Gene namesi
Name:dppB
Ordered Locus Names:b3543, JW3512
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12625. dppB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99PeriplasmicSequence analysis
Transmembranei10 – 3021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini31 – 10272CytoplasmicSequence analysisAdd
BLAST
Transmembranei103 – 12321HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini124 – 13512PeriplasmicSequence analysisAdd
BLAST
Transmembranei136 – 15621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini157 – 17115CytoplasmicSequence analysisAdd
BLAST
Transmembranei172 – 19221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini193 – 2008PeriplasmicSequence analysis
Transmembranei201 – 22121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini222 – 25938CytoplasmicSequence analysisAdd
BLAST
Transmembranei260 – 28021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini281 – 30929PeriplasmicSequence analysisAdd
BLAST
Transmembranei310 – 33021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini331 – 3399CytoplasmicSequence analysis

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • integral component of membrane Source: EcoCyc
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Dipeptide transport system permease protein DppBPRO_0000060005Add
BLAST

Proteomic databases

PaxDbiP0AEF8.

Interactioni

Protein-protein interaction databases

BioGridi4262535. 115 interactions.
DIPiDIP-47927N.
IntActiP0AEF8. 2 interactions.
MINTiMINT-1309644.
STRINGi511145.b3543.

Structurei

3D structure databases

ProteinModelPortaliP0AEF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 328233ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CJM. Bacteria.
COG0601. LUCA.
HOGENOMiHOG000170242.
InParanoidiP0AEF8.
KOiK12369.
OMAiITRYTRS.
PhylomeDBiP0AEF8.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 2 hits.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 2 hits.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AEF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQFILRRLG LVIPTFIGIT LLTFAFVHMI PGDPVMIMAG ERGISPERHA
60 70 80 90 100
QLLAELGLDK PMWQQYLHYI WGVMHGDLGI SMKSRIPVWE EFVPRFQATL
110 120 130 140 150
ELGVCAMIFA TAVGIPVGVL AAVKRGSIFD HTAVGLALTG YSMPIFWWGM
160 170 180 190 200
MLIMLVSVHW NLTPVSGRVS DMVFLDDSNP LTGFMLIDTA IWGEDGNFID
210 220 230 240 250
AVAHMILPAI VLGTIPLAVI VRMTRSSMLE VLGEDYIRTA RAKGLTRMRV
260 270 280 290 300
IIVHALRNAM LPVVTVIGLQ VGTLLAGAIL TETIFSWPGL GRWLIDALQR
310 320 330
RDYPVVQGGV LLVATMIILV NLLVDLLYGV VNPRIRHKK
Length:339
Mass (Da):37,497
Last modified:December 6, 2005 - v1
Checksum:iB4B9D2965C365AD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08399 Genomic DNA. Translation: AAA23703.1.
U00039 Genomic DNA. Translation: AAB18521.1.
U00096 Genomic DNA. Translation: AAC76568.1.
AP009048 Genomic DNA. Translation: BAE77751.1.
PIRiS47765.
RefSeqiNP_418000.1. NC_000913.3.
WP_000938855.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76568; AAC76568; b3543.
BAE77751; BAE77751; BAE77751.
GeneIDi948063.
KEGGiecj:JW3512.
eco:b3543.
PATRICi32122554. VBIEscCol129921_3655.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08399 Genomic DNA. Translation: AAA23703.1.
U00039 Genomic DNA. Translation: AAB18521.1.
U00096 Genomic DNA. Translation: AAC76568.1.
AP009048 Genomic DNA. Translation: BAE77751.1.
PIRiS47765.
RefSeqiNP_418000.1. NC_000913.3.
WP_000938855.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AEF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262535. 115 interactions.
DIPiDIP-47927N.
IntActiP0AEF8. 2 interactions.
MINTiMINT-1309644.
STRINGi511145.b3543.

Proteomic databases

PaxDbiP0AEF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76568; AAC76568; b3543.
BAE77751; BAE77751; BAE77751.
GeneIDi948063.
KEGGiecj:JW3512.
eco:b3543.
PATRICi32122554. VBIEscCol129921_3655.

Organism-specific databases

EchoBASEiEB2509.
EcoGeneiEG12625. dppB.

Phylogenomic databases

eggNOGiENOG4105CJM. Bacteria.
COG0601. LUCA.
HOGENOMiHOG000170242.
InParanoidiP0AEF8.
KOiK12369.
OMAiITRYTRS.
PhylomeDBiP0AEF8.

Enzyme and pathway databases

BioCyciEcoCyc:DPPB-MONOMER.
ECOL316407:JW3512-MONOMER.
MetaCyc:DPPB-MONOMER.
RETL1328306-WGS:GSTH-2068-MONOMER.
RETL1328306-WGS:GSTH-4082-MONOMER.
RETL1328306-WGS:GSTH-4924-MONOMER.
RETL1328306-WGS:GSTH-749-MONOMER.

Miscellaneous databases

PROiP0AEF8.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 2 hits.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 2 hits.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPPB_ECOLI
AccessioniPrimary (citable) accession number: P0AEF8
Secondary accession number(s): P37316, Q2M7K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.