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P0AEE0

- DCM_ECO57

UniProt

P0AEE0 - DCM_ECO57

Protein

DNA-cytosine methyltransferase

Gene

dcm

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence CCWGG, causes specific methylation on C-2 on both strands.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei177 – 1771PROSITE-ProRule annotation

    GO - Molecular functioni

    1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
    2. DNA binding Source: InterPro

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-2663-MONOMER.
    ECOO157:DCM-MONOMER.

    Protein family/group databases

    REBASEi5589. M.EcoKO157DcmP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-cytosine methyltransferase (EC:2.1.1.37)
    Gene namesi
    Name:dcm
    Ordered Locus Names:Z3054, ECs2699
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472DNA-cytosine methyltransferasePRO_0000087914Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1237409.
    STRINGi155864.Z3054.

    Structurei

    3D structure databases

    ProteinModelPortaliP0AEE0.
    SMRiP0AEE0. Positions 15-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini87 – 457371SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
    Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0270.
    HOGENOMiHOG000225506.
    KOiK00558.
    OMAiIDGRHFL.
    OrthoDBiEOG6PZXGV.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10629. PTHR10629. 1 hit.
    PfamiPF00145. DNA_methylase. 1 hit.
    [Graphical view]
    PRINTSiPR00105. C5METTRFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00675. dcm. 1 hit.
    PROSITEiPS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0AEE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQENISVTDS YSTGNAAQAM LEKLLQIYDV KTLVAQLNGV GENHWSAAIL    50
    KRALANDSAW HRLSEKEFAH LQTLLPKPPA HHPHYAFRFI DLFAGIGGIR 100
    RGFESIGGQC VFTSEWNKHA VRTYKANHYC DPATHHFNED IRDITLSHKE 150
    GVSDEAAAEH IRQHIPEHDV LLAGFPCQPF SLAGVSKKNS LGRAHGFACD 200
    TQGTLFFDVV RIIDARRPAM FVLENVKNLK SHDQGKTFRI IMQTLDELGY 250
    DVADAEDNGP DDPKIIDGKH FLPQHRERIV LVGFRRDLNL KADFTLRDIS 300
    ECFPAQRVTL AQLLDPMVEA KYILTPVLWK YLYRYAKKHQ ARGNGFGYGM 350
    VYPNNPQSVT RTLSARYYKD GAEILIDRGW DMATGEKDFD DPLNQQHRPR 400
    RLTPRECARL MGFEAPGEAK FRIPVSDTQA YRQFGNSVVV PVFAAVAKLL 450
    EPKIKQAVAL RQQEAQHGRR SR 472
    Length:472
    Mass (Da):53,465
    Last modified:December 6, 2005 - v1
    Checksum:i3635BFC001CF94B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG56975.1.
    BA000007 Genomic DNA. Translation: BAB36122.1.
    PIRiC85814.
    C90966.
    RefSeqiNP_288421.1. NC_002655.2.
    NP_310726.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG56975; AAG56975; Z3054.
    BAB36122; BAB36122; BAB36122.
    GeneIDi913056.
    961961.
    KEGGiece:Z3054.
    ecs:ECs2699.
    PATRICi18354786. VBIEscCol44059_2601.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG56975.1 .
    BA000007 Genomic DNA. Translation: BAB36122.1 .
    PIRi C85814.
    C90966.
    RefSeqi NP_288421.1. NC_002655.2.
    NP_310726.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali P0AEE0.
    SMRi P0AEE0. Positions 15-466.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1237409.
    STRINGi 155864.Z3054.

    Protein family/group databases

    REBASEi 5589. M.EcoKO157DcmP.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG56975 ; AAG56975 ; Z3054 .
    BAB36122 ; BAB36122 ; BAB36122 .
    GeneIDi 913056.
    961961.
    KEGGi ece:Z3054.
    ecs:ECs2699.
    PATRICi 18354786. VBIEscCol44059_2601.

    Phylogenomic databases

    eggNOGi COG0270.
    HOGENOMi HOG000225506.
    KOi K00558.
    OMAi IDGRHFL.
    OrthoDBi EOG6PZXGV.

    Enzyme and pathway databases

    BioCyci ECOL386585:GJFA-2663-MONOMER.
    ECOO157:DCM-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10629. PTHR10629. 1 hit.
    Pfami PF00145. DNA_methylase. 1 hit.
    [Graphical view ]
    PRINTSi PR00105. C5METTRFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00675. dcm. 1 hit.
    PROSITEi PS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiDCM_ECO57
    AccessioniPrimary (citable) accession number: P0AEE0
    Secondary accession number(s): P11876
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3