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Protein

Response regulator UvrY

Gene

uvrY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the effects of CsrA on csrB RNA by BarA-dependent and BarA-independent mechanisms.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi167 – 18620H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • phosphorelay response regulator activity Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11140-MONOMER.
ECOL316407:JW1899-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Response regulator UvrY
Gene namesi
Name:uvrY
Synonyms:yecB
Ordered Locus Names:b1914, JW1899
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11140. uvrY.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Response regulator UvrYPRO_0000081292Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 5414-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated and activated by BarA.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0AED5.
PRIDEiP0AED5.

Expressioni

Inductioni

Expression is regulated by SidA.

Interactioni

Protein-protein interaction databases

BioGridi4261107. 99 interactions.
DIPiDIP-35922N.
IntActiP0AED5. 37 interactions.
MINTiMINT-1243107.
STRINGi511145.b1914.

Structurei

3D structure databases

ProteinModelPortaliP0AED5.
SMRiP0AED5. Positions 2-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 119117Response regulatoryPROSITE-ProRule annotationAdd
BLAST
Domaini143 – 20866HTH luxR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105WH1. Bacteria.
COG2197. LUCA.
HOGENOMiHOG000034813.
InParanoidiP0AED5.
KOiK07689.
OMAiVICAIRS.
PhylomeDBiP0AED5.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AED5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINVLLVDDH ELVRAGIRRI LEDIKGIKVV GEASCGEDAV KWCRTNAVDV
60 70 80 90 100
VLMDMSMPGI GGLEATRKIA RSTADVKIIM LTVHTENPLP AKVMQAGAAG
110 120 130 140 150
YLSKGAAPQE VVSAIRSVYS GQRYIASDIA QQMALSQIEP EKTESPFASL
160 170 180 190 200
SERELQIMLM ITKGQKVNEI SEQLNLSPKT VNSYRYRMFS KLNIHGDVEL
210
THLAIRHGLC NAETLSSQ
Length:218
Mass (Da):23,893
Last modified:December 6, 2005 - v1
Checksum:i708E52D8BFA97716
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 92DD → MT in CAA27328 (PubMed:3515318).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24615 Genomic DNA. Translation: AAA24755.1.
U00096 Genomic DNA. Translation: AAC74981.1.
AP009048 Genomic DNA. Translation: BAA15734.1.
X05398 Genomic DNA. Translation: CAA28982.1.
X03691 Genomic DNA. Translation: CAA27328.1.
PIRiA26750. QQEC24.
RefSeqiNP_416424.1. NC_000913.3.
WP_000611335.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74981; AAC74981; b1914.
BAA15734; BAA15734; BAA15734.
GeneIDi946424.
KEGGiecj:JW1899.
eco:b1914.
PATRICi32119161. VBIEscCol129921_1995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24615 Genomic DNA. Translation: AAA24755.1.
U00096 Genomic DNA. Translation: AAC74981.1.
AP009048 Genomic DNA. Translation: BAA15734.1.
X05398 Genomic DNA. Translation: CAA28982.1.
X03691 Genomic DNA. Translation: CAA27328.1.
PIRiA26750. QQEC24.
RefSeqiNP_416424.1. NC_000913.3.
WP_000611335.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AED5.
SMRiP0AED5. Positions 2-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261107. 99 interactions.
DIPiDIP-35922N.
IntActiP0AED5. 37 interactions.
MINTiMINT-1243107.
STRINGi511145.b1914.

Proteomic databases

PaxDbiP0AED5.
PRIDEiP0AED5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74981; AAC74981; b1914.
BAA15734; BAA15734; BAA15734.
GeneIDi946424.
KEGGiecj:JW1899.
eco:b1914.
PATRICi32119161. VBIEscCol129921_1995.

Organism-specific databases

EchoBASEiEB1130.
EcoGeneiEG11140. uvrY.

Phylogenomic databases

eggNOGiENOG4105WH1. Bacteria.
COG2197. LUCA.
HOGENOMiHOG000034813.
InParanoidiP0AED5.
KOiK07689.
OMAiVICAIRS.
PhylomeDBiP0AED5.

Enzyme and pathway databases

BioCyciEcoCyc:EG11140-MONOMER.
ECOL316407:JW1899-MONOMER.

Miscellaneous databases

PROiP0AED5.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUVRY_ECOLI
AccessioniPrimary (citable) accession number: P0AED5
Secondary accession number(s): P07027
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.