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Protein

UPF0053 inner membrane protein YoaE

Gene

yoaE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G6997-MONOMER.
ECOL316407:JW1805-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0053 inner membrane protein YoaE
Gene namesi
Name:yoaE
Ordered Locus Names:b1816, JW1805
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13517. yoaE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence analysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Topological domaini35 – 4814PeriplasmicSequence analysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence analysisAdd
BLAST
Topological domaini70 – 789CytoplasmicSequence analysis
Transmembranei79 – 9921HelicalSequence analysisAdd
BLAST
Topological domaini100 – 12425PeriplasmicSequence analysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence analysisAdd
BLAST
Topological domaini146 – 1494CytoplasmicSequence analysis
Transmembranei150 – 17021HelicalSequence analysisAdd
BLAST
Topological domaini171 – 18414PeriplasmicSequence analysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence analysisAdd
BLAST
Topological domaini206 – 2061CytoplasmicSequence analysis
Transmembranei207 – 22721HelicalSequence analysisAdd
BLAST
Topological domaini228 – 354127PeriplasmicSequence analysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence analysisAdd
BLAST
Topological domaini376 – 518143CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518UPF0053 inner membrane protein YoaEPRO_0000088359Add
BLAST

Proteomic databases

PaxDbiP0AEC0.

Interactioni

Protein-protein interaction databases

BioGridi4260347. 12 interactions.
IntActiP0AEC0. 1 interaction.
STRINGi511145.b1816.

Structurei

3D structure databases

ProteinModelPortaliP0AEC0.
SMRiP0AEC0. Positions 280-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini304 – 36360CBS 1PROSITE-ProRule annotationAdd
BLAST
Domaini367 – 42761CBS 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0053 family.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EE5. Bacteria.
COG0861. LUCA.
COG1253. LUCA.
HOGENOMiHOG000279402.
InParanoidiP0AEC0.
OMAiMRFINRH.
OrthoDBiEOG6F297P.
PhylomeDBiP0AEC0.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005496. Integral_membrane_TerC.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF03471. CorC_HlyC. 1 hit.
PF03741. TerC. 1 hit.
[Graphical view]
SMARTiSM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AEC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFLMDPSIW AGLLTLVVLE IVLGIDNLVF IAILADKLPP KQRDKARLLG
60 70 80 90 100
LSLALIMRLG LLSLISWMVT LTKPLFTVMD FSFSGRDLIM LFGGIFLLFK
110 120 130 140 150
ATTELHERLE NRDHDSGHGK GYASFWVVVT QIVILDAVFS LDAVITAVGM
160 170 180 190 200
VNHLPVMMAA VVIAMAVMLL ASKPLTRFVN QHPTVVVLCL SFLLMIGLSL
210 220 230 240 250
VAEGFGFHIP KGYLYAAIGF SIIIEVFNQI ARRNFIRHQS TLPLRARTAD
260 270 280 290 300
AILRLMGGKR QANVQHDADN PMPMPIPEGA FAEEERYMIN GVLTLASRSL
310 320 330 340 350
RGIMTPRGEI SWVDANLGVD EIREQLLSSP HSLFPVCRGE LDEIIGIVRA
360 370 380 390 400
KELLVALEEG VDVAAIASAS PAIIVPETLD PINLLGVLRR ARGSFVIVTN
410 420 430 440 450
EFGVVQGLVT PLDVLEAIAG EFPDADETPE IITDGDGWLV KGGTDLHALQ
460 470 480 490 500
QALDVEHLAD DDDIATVAGL VISANGHIPR VGDVIDVGPL HITIIEANDY
510
RVDLVRIVKE QPAHDEDE
Length:518
Mass (Da):56,528
Last modified:December 6, 2005 - v1
Checksum:i90DF7C9A092F1ECC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74886.1.
AP009048 Genomic DNA. Translation: BAA15623.1.
PIRiH64942.
RefSeqiNP_416330.1. NC_000913.3.
WP_000394983.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74886; AAC74886; b1816.
BAA15623; BAA15623; BAA15623.
GeneIDi946335.
KEGGiecj:JW1805.
eco:b1816.
PATRICi32118951. VBIEscCol129921_1893.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74886.1.
AP009048 Genomic DNA. Translation: BAA15623.1.
PIRiH64942.
RefSeqiNP_416330.1. NC_000913.3.
WP_000394983.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AEC0.
SMRiP0AEC0. Positions 280-507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260347. 12 interactions.
IntActiP0AEC0. 1 interaction.
STRINGi511145.b1816.

Proteomic databases

PaxDbiP0AEC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74886; AAC74886; b1816.
BAA15623; BAA15623; BAA15623.
GeneIDi946335.
KEGGiecj:JW1805.
eco:b1816.
PATRICi32118951. VBIEscCol129921_1893.

Organism-specific databases

EchoBASEiEB3290.
EcoGeneiEG13517. yoaE.

Phylogenomic databases

eggNOGiENOG4105EE5. Bacteria.
COG0861. LUCA.
COG1253. LUCA.
HOGENOMiHOG000279402.
InParanoidiP0AEC0.
OMAiMRFINRH.
OrthoDBiEOG6F297P.
PhylomeDBiP0AEC0.

Enzyme and pathway databases

BioCyciEcoCyc:G6997-MONOMER.
ECOL316407:JW1805-MONOMER.

Miscellaneous databases

PROiP0AEC0.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005496. Integral_membrane_TerC.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF03471. CorC_HlyC. 1 hit.
PF03741. TerC. 1 hit.
[Graphical view]
SMARTiSM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYOAE_ECOLI
AccessioniPrimary (citable) accession number: P0AEC0
Secondary accession number(s): P76262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: January 20, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.