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Protein

Low conductance mechanosensitive channel YnaI

Gene

ynaI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-82.
ECOL316407:JW1323-MONOMER.

Protein family/group databases

TCDBi1.A.23.4.3. the small conductance mechanosensitive ion channel (mscs) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Low conductance mechanosensitive channel YnaI
Gene namesi
Name:ynaI
Ordered Locus Names:b1330, JW1323
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13924. ynaI.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9PeriplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 40CytoplasmicSequence analysis10
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Topological domaini62 – 77PeriplasmicSequence analysisAdd BLAST16
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 125CytoplasmicSequence analysisAdd BLAST27
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147PeriplasmicSequence analysis1
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169 – 343CytoplasmicSequence analysisAdd BLAST175

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001102421 – 343Low conductance mechanosensitive channel YnaIAdd BLAST343

Proteomic databases

PaxDbiP0AEB5.
PRIDEiP0AEB5.

Interactioni

Subunit structurei

Homoheptamer.1 Publication

Protein-protein interaction databases

BioGridi4260142. 189 interactors.
DIPiDIP-12740N.
IntActiP0AEB5. 3 interactors.
STRINGi511145.b1330.

Structurei

3D structure databases

ProteinModelPortaliP0AEB5.
SMRiP0AEB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D64. Bacteria.
COG0668. LUCA.
HOGENOMiHOG000060775.
InParanoidiP0AEB5.
KOiK16052.
OMAiSRIQNYR.
PhylomeDBiP0AEB5.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR011066. MscC_channel_C.
IPR006685. MscS_channel.
IPR006686. MscS_channel_CS.
IPR011014. MscS_channel_TM-2.
[Graphical view]
PfamiPF00924. MS_channel. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
SSF82689. SSF82689. 1 hit.
SSF82861. SSF82861. 1 hit.
PROSITEiPS01246. UPF0003. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AEB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAELFTNNA LNLVIIFGSC AALILMSFWF RRGNRKRKGF LFHAVQFLIY
60 70 80 90 100
TIIISAVGSI INYVIENYKL KFITPGVIDF ICTSLIAVIL TIKLFLLINQ
110 120 130 140 150
FEKQQIKKGR DITSARIMSR IIKITIIVVL VLLYGEHFGM SLSGLLTFGG
160 170 180 190 200
IGGLAVGMAG KDILSNFFSG IMLYFDRPFS IGDWIRSPDR NIEGTVAEIG
210 220 230 240 250
WRITKITTFD NRPLYVPNSL FSSISVENPG RMTNRRITTT IGLRYEDAAK
260 270 280 290 300
VGVIVEAVRE MLKNHPAIDQ RQTLLVYFNQ FADSSLNIMV YCFTKTTVWA
310 320 330 340
EWLAAQQDVY LKIIDIVQSH GADFAFPSQT LYMDNITPPE QGR
Length:343
Mass (Da):38,755
Last modified:December 6, 2005 - v1
Checksum:i469F0B7909480D13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74412.1.
AP009048 Genomic DNA. Translation: BAA14923.1.
PIRiE64882.
RefSeqiNP_415846.1. NC_000913.3.
WP_000559900.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74412; AAC74412; b1330.
BAA14923; BAA14923; BAA14923.
GeneIDi945898.
KEGGiecj:JW1323.
eco:b1330.
PATRICi32117936. VBIEscCol129921_1388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74412.1.
AP009048 Genomic DNA. Translation: BAA14923.1.
PIRiE64882.
RefSeqiNP_415846.1. NC_000913.3.
WP_000559900.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AEB5.
SMRiP0AEB5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260142. 189 interactors.
DIPiDIP-12740N.
IntActiP0AEB5. 3 interactors.
STRINGi511145.b1330.

Protein family/group databases

TCDBi1.A.23.4.3. the small conductance mechanosensitive ion channel (mscs) family.

Proteomic databases

PaxDbiP0AEB5.
PRIDEiP0AEB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74412; AAC74412; b1330.
BAA14923; BAA14923; BAA14923.
GeneIDi945898.
KEGGiecj:JW1323.
eco:b1330.
PATRICi32117936. VBIEscCol129921_1388.

Organism-specific databases

EchoBASEiEB3683.
EcoGeneiEG13924. ynaI.

Phylogenomic databases

eggNOGiENOG4105D64. Bacteria.
COG0668. LUCA.
HOGENOMiHOG000060775.
InParanoidiP0AEB5.
KOiK16052.
OMAiSRIQNYR.
PhylomeDBiP0AEB5.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-82.
ECOL316407:JW1323-MONOMER.

Miscellaneous databases

PROiP0AEB5.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR011066. MscC_channel_C.
IPR006685. MscS_channel.
IPR006686. MscS_channel_CS.
IPR011014. MscS_channel_TM-2.
[Graphical view]
PfamiPF00924. MS_channel. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
SSF82689. SSF82689. 1 hit.
SSF82861. SSF82861. 1 hit.
PROSITEiPS01246. UPF0003. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYNAI_ECOLI
AccessioniPrimary (citable) accession number: P0AEB5
Secondary accession number(s): P77253
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.