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Protein

Low conductance mechanosensitive channel YnaI

Gene

ynaI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-82

Protein family/group databases

TCDBi1.A.23.4.3 the small conductance mechanosensitive ion channel (mscs) family

Names & Taxonomyi

Protein namesi
Recommended name:
Low conductance mechanosensitive channel YnaI
Gene namesi
Name:ynaI
Ordered Locus Names:b1330, JW1323
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13924 ynaI

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9PeriplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 40CytoplasmicSequence analysis10
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Topological domaini62 – 77PeriplasmicSequence analysisAdd BLAST16
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 125CytoplasmicSequence analysisAdd BLAST27
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147PeriplasmicSequence analysis1
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169 – 343CytoplasmicSequence analysisAdd BLAST175

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001102421 – 343Low conductance mechanosensitive channel YnaIAdd BLAST343

Proteomic databases

PaxDbiP0AEB5
PRIDEiP0AEB5

Interactioni

Subunit structurei

Homoheptamer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-9141361,EBI-9141361

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4260142, 225 interactors
DIPiDIP-12740N
IntActiP0AEB5, 3 interactors
STRINGi316385.ECDH10B_1450

Structurei

3D structure databases

ProteinModelPortaliP0AEB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D64 Bacteria
COG0668 LUCA
HOGENOMiHOG000060775
InParanoidiP0AEB5
KOiK16052
OMAiINWSHND
PhylomeDBiP0AEB5

Family and domain databases

Gene3Di2.30.30.60, 1 hit
InterProiView protein in InterPro
IPR010920 LSM_dom_sf
IPR011066 MscC_channel_C
IPR006685 MscS_channel
IPR006686 MscS_channel_CS
IPR011014 MscS_channel_TM-2
IPR023408 MscS_dom_sf
PfamiView protein in Pfam
PF00924 MS_channel, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
SSF82689 SSF82689, 1 hit
SSF82861 SSF82861, 1 hit
PROSITEiView protein in PROSITE
PS01246 UPF0003, 1 hit

Sequencei

Sequence statusi: Complete.

P0AEB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAELFTNNA LNLVIIFGSC AALILMSFWF RRGNRKRKGF LFHAVQFLIY
60 70 80 90 100
TIIISAVGSI INYVIENYKL KFITPGVIDF ICTSLIAVIL TIKLFLLINQ
110 120 130 140 150
FEKQQIKKGR DITSARIMSR IIKITIIVVL VLLYGEHFGM SLSGLLTFGG
160 170 180 190 200
IGGLAVGMAG KDILSNFFSG IMLYFDRPFS IGDWIRSPDR NIEGTVAEIG
210 220 230 240 250
WRITKITTFD NRPLYVPNSL FSSISVENPG RMTNRRITTT IGLRYEDAAK
260 270 280 290 300
VGVIVEAVRE MLKNHPAIDQ RQTLLVYFNQ FADSSLNIMV YCFTKTTVWA
310 320 330 340
EWLAAQQDVY LKIIDIVQSH GADFAFPSQT LYMDNITPPE QGR
Length:343
Mass (Da):38,755
Last modified:December 6, 2005 - v1
Checksum:i469F0B7909480D13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74412.1
AP009048 Genomic DNA Translation: BAA14923.1
PIRiE64882
RefSeqiNP_415846.1, NC_000913.3
WP_000559900.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74412; AAC74412; b1330
BAA14923; BAA14923; BAA14923
GeneIDi945898
KEGGiecj:JW1323
eco:b1330
PATRICifig|1411691.4.peg.947

Similar proteinsi

Entry informationi

Entry nameiYNAI_ECOLI
AccessioniPrimary (citable) accession number: P0AEB5
Secondary accession number(s): P77253
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health