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Protein

Sulfate transport system permease protein CysW

Gene

cysW

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

Keywordsi

Biological processSulfate transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CYSW-MONOMER.
MetaCyc:CYSW-MONOMER.

Protein family/group databases

TCDBi3.A.1.6.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate transport system permease protein CysW
Gene namesi
Name:cysW
Ordered Locus Names:b2423, JW2416
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10198. cysW.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini44 – 69PeriplasmicSequence analysisAdd BLAST26
Transmembranei70 – 90HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini91 – 104CytoplasmicSequence analysisAdd BLAST14
Transmembranei105 – 125HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini126 – 141PeriplasmicSequence analysisAdd BLAST16
Transmembranei142 – 162HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini163 – 200CytoplasmicSequence analysisAdd BLAST38
Transmembranei201 – 221HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini222 – 247PeriplasmicSequence analysisAdd BLAST26
Transmembranei248 – 268HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini269 – 291CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000599971 – 291Sulfate transport system permease protein CysWAdd BLAST291

Proteomic databases

PaxDbiP0AEB0.
PRIDEiP0AEB0.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).Curated

Protein-protein interaction databases

BioGridi4260746. 7 interactors.
DIPiDIP-9388N.
IntActiP0AEB0. 1 interactor.
MINTiMINT-1250777.
STRINGi316385.ECDH10B_2588.

Structurei

3D structure databases

ProteinModelPortaliP0AEB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 270ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST205

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105ECW. Bacteria.
COG4208. LUCA.
HOGENOMiHOG000263697.
InParanoidiP0AEB0.
KOiK02047.
PhylomeDBiP0AEB0.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
InterProiView protein in InterPro
IPR011866. CysW_permease.
IPR000515. MetI-like.
IPR005667. Sulph_transpt2.
PANTHERiPTHR30406. PTHR30406. 1 hit.
PTHR30406:SF8. PTHR30406:SF8. 1 hit.
PfamiView protein in Pfam
PF00528. BPD_transp_1. 1 hit.
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR00969. 3a0106s02. 1 hit.
TIGR02140. permease_CysW. 1 hit.
PROSITEiView protein in PROSITE
PS50928. ABC_TM1. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AEB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVTQLKRY DARPINWGKW FLIGIGMLVS AFILLVPMIY IFVQAFSKGL
60 70 80 90 100
MPVLQNLADP DMLHAIWLTV MIALIAVPVN LVFGILLAWL VTRFNFPGRQ
110 120 130 140 150
LLLTLLDIPF AVSPVVAGLV YLLFYGSNGP LGGWLDEHNL QIMFSWPGMV
160 170 180 190 200
LVTIFVTCPF VVRELVPVML SQGSQEDEAA ILLGASGWQM FRRVTLPNIR
210 220 230 240 250
WALLYGVVLT NARAIGEFGA VSVVSGSIRG ETLSLPLQIE LLEQDYNTVG
260 270 280 290
SFTAAALLTL MAIITLFLKS MLQWRLENQE KRAQQEEHHE H
Length:291
Mass (Da):32,538
Last modified:December 6, 2005 - v1
Checksum:i1878BEA4EB3F6E67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32101 Genomic DNA. Translation: AAA23638.1.
U00096 Genomic DNA. Translation: AAC75476.2.
AP009048 Genomic DNA. Translation: BAA16297.1.
PIRiF65016. QRECSW.
RefSeqiWP_000852686.1. NZ_LN832404.1.
YP_026168.2. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC75476; AAC75476; b2423.
BAA16297; BAA16297; BAA16297.
GeneIDi2847743.
KEGGiecj:JW2416.
eco:b2423.
PATRICifig|1411691.4.peg.4308.

Similar proteinsi

Entry informationi

Entry nameiCYSW_ECOLI
AccessioniPrimary (citable) accession number: P0AEB0
Secondary accession number(s): P16702, P76534
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: September 27, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families