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Protein

Sulfate transport system permease protein CysW

Gene

cysW

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Sulfate transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:CYSW-MONOMER.
ECOL316407:JW2416-MONOMER.
MetaCyc:CYSW-MONOMER.
RETL1328306-WGS:GSTH-6116-MONOMER.

Protein family/group databases

TCDBi3.A.1.6.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate transport system permease protein CysW
Gene namesi
Name:cysW
Ordered Locus Names:b2423, JW2416
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10198. cysW.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence analysisAdd
BLAST
Transmembranei23 – 4321HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini44 – 6926PeriplasmicSequence analysisAdd
BLAST
Transmembranei70 – 9021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini91 – 10414CytoplasmicSequence analysisAdd
BLAST
Transmembranei105 – 12521HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini126 – 14116PeriplasmicSequence analysisAdd
BLAST
Transmembranei142 – 16221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini163 – 20038CytoplasmicSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini222 – 24726PeriplasmicSequence analysisAdd
BLAST
Transmembranei248 – 26821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini269 – 29123CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Sulfate transport system permease protein CysWPRO_0000059997Add
BLAST

Proteomic databases

PaxDbiP0AEB0.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).Curated

Protein-protein interaction databases

BioGridi4260746. 7 interactions.
DIPiDIP-9388N.
IntActiP0AEB0. 1 interaction.
MINTiMINT-1250777.
STRINGi511145.b2423.

Structurei

3D structure databases

ProteinModelPortaliP0AEB0.
SMRiP0AEB0. Positions 32-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 270205ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105ECW. Bacteria.
COG4208. LUCA.
HOGENOMiHOG000263697.
InParanoidiP0AEB0.
KOiK02047.
OMAiYQFSAAF.
PhylomeDBiP0AEB0.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR011866. CysW_permease.
IPR000515. MetI-like.
IPR005667. Sulph_transpt2.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR00969. 3a0106s02. 1 hit.
TIGR02140. permease_CysW. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AEB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVTQLKRY DARPINWGKW FLIGIGMLVS AFILLVPMIY IFVQAFSKGL
60 70 80 90 100
MPVLQNLADP DMLHAIWLTV MIALIAVPVN LVFGILLAWL VTRFNFPGRQ
110 120 130 140 150
LLLTLLDIPF AVSPVVAGLV YLLFYGSNGP LGGWLDEHNL QIMFSWPGMV
160 170 180 190 200
LVTIFVTCPF VVRELVPVML SQGSQEDEAA ILLGASGWQM FRRVTLPNIR
210 220 230 240 250
WALLYGVVLT NARAIGEFGA VSVVSGSIRG ETLSLPLQIE LLEQDYNTVG
260 270 280 290
SFTAAALLTL MAIITLFLKS MLQWRLENQE KRAQQEEHHE H
Length:291
Mass (Da):32,538
Last modified:December 6, 2005 - v1
Checksum:i1878BEA4EB3F6E67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32101 Genomic DNA. Translation: AAA23638.1.
U00096 Genomic DNA. Translation: AAC75476.2.
AP009048 Genomic DNA. Translation: BAA16297.1.
PIRiF65016. QRECSW.
RefSeqiWP_000852686.1. NZ_LN832404.1.
YP_026168.2. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC75476; AAC75476; b2423.
BAA16297; BAA16297; BAA16297.
GeneIDi2847743.
KEGGiecj:JW2416.
eco:b2423.
PATRICi32120231. VBIEscCol129921_2518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32101 Genomic DNA. Translation: AAA23638.1.
U00096 Genomic DNA. Translation: AAC75476.2.
AP009048 Genomic DNA. Translation: BAA16297.1.
PIRiF65016. QRECSW.
RefSeqiWP_000852686.1. NZ_LN832404.1.
YP_026168.2. NC_000913.3.

3D structure databases

ProteinModelPortaliP0AEB0.
SMRiP0AEB0. Positions 32-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260746. 7 interactions.
DIPiDIP-9388N.
IntActiP0AEB0. 1 interaction.
MINTiMINT-1250777.
STRINGi511145.b2423.

Protein family/group databases

TCDBi3.A.1.6.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0AEB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75476; AAC75476; b2423.
BAA16297; BAA16297; BAA16297.
GeneIDi2847743.
KEGGiecj:JW2416.
eco:b2423.
PATRICi32120231. VBIEscCol129921_2518.

Organism-specific databases

EchoBASEiEB0195.
EcoGeneiEG10198. cysW.

Phylogenomic databases

eggNOGiENOG4105ECW. Bacteria.
COG4208. LUCA.
HOGENOMiHOG000263697.
InParanoidiP0AEB0.
KOiK02047.
OMAiYQFSAAF.
PhylomeDBiP0AEB0.

Enzyme and pathway databases

BioCyciEcoCyc:CYSW-MONOMER.
ECOL316407:JW2416-MONOMER.
MetaCyc:CYSW-MONOMER.
RETL1328306-WGS:GSTH-6116-MONOMER.

Miscellaneous databases

PROiP0AEB0.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR011866. CysW_permease.
IPR000515. MetI-like.
IPR005667. Sulph_transpt2.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR00969. 3a0106s02. 1 hit.
TIGR02140. permease_CysW. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYSW_ECOLI
AccessioniPrimary (citable) accession number: P0AEB0
Secondary accession number(s): P16702, P76534
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.