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Protein

Transcriptional regulatory protein CpxR

Gene

cpxR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:CPXR-MONOMER.
ECOL316407:JW3883-MONOMER.
RETL1328306-WGS:GSTH-6652-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein CpxR
Gene namesi
Name:cpxR
Synonyms:yiiA
Ordered Locus Names:b3912, JW3883
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10020. cpxR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Transcriptional regulatory protein CpxRPRO_0000081078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 5114-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by CpxA.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0AE88.

Expressioni

Gene expression databases

GenevestigatoriP0AE88.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
lysAP008612EBI-550918,EBI-553837

Protein-protein interaction databases

DIPiDIP-47991N.
IntActiP0AE88. 11 interactions.
MINTiMINT-1292432.
STRINGi511145.b3912.

Structurei

3D structure databases

ProteinModelPortaliP0AE88.
SMRiP0AE88. Positions 3-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 115115Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034819.
InParanoidiP0AE88.
KOiK07662.
OMAiLSMIGYQ.
OrthoDBiEOG6G4VQG.
PhylomeDBiP0AE88.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AE88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKILLVDDD RELTSLLKEL LEMEGFNVIV AHDGEQALDL LDDSIDLLLL
60 70 80 90 100
DVMMPKKNGI DTLKALRQTH QTPVIMLTAR GSELDRVLGL ELGADDYLPK
110 120 130 140 150
PFNDRELVAR IRAILRRSHW SEQQQNNDNG SPTLEVDALV LNPGRQEASF
160 170 180 190 200
DGQTLELTGT EFTLLYLLAQ HLGQVVSREH LSQEVLGKRL TPFDRAIDMH
210 220 230
ISNLRRKLPD RKDGHPWFKT LRGRGYLMVS AS
Length:232
Mass (Da):26,312
Last modified:December 6, 2005 - v1
Checksum:i667FC2B246082F46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14579 Unassigned DNA. Translation: AAC36868.1.
L19201 Genomic DNA. Translation: AAB03045.1.
U00096 Genomic DNA. Translation: AAC76894.1.
AP009048 Genomic DNA. Translation: BAE77397.1.
X13307 Genomic DNA. Translation: CAA31686.1.
M36795 Genomic DNA. Translation: AAA23599.1.
PIRiC65197.
RefSeqiNP_418348.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC76894; AAC76894; b3912.
BAE77397; BAE77397; BAE77397.
GeneIDi948404.
KEGGiecj:Y75_p3274.
eco:b3912.
PATRICi32123337. VBIEscCol129921_4029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14579 Unassigned DNA. Translation: AAC36868.1.
L19201 Genomic DNA. Translation: AAB03045.1.
U00096 Genomic DNA. Translation: AAC76894.1.
AP009048 Genomic DNA. Translation: BAE77397.1.
X13307 Genomic DNA. Translation: CAA31686.1.
M36795 Genomic DNA. Translation: AAA23599.1.
PIRiC65197.
RefSeqiNP_418348.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP0AE88.
SMRiP0AE88. Positions 3-228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-47991N.
IntActiP0AE88. 11 interactions.
MINTiMINT-1292432.
STRINGi511145.b3912.

Proteomic databases

PaxDbiP0AE88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76894; AAC76894; b3912.
BAE77397; BAE77397; BAE77397.
GeneIDi948404.
KEGGiecj:Y75_p3274.
eco:b3912.
PATRICi32123337. VBIEscCol129921_4029.

Organism-specific databases

EchoBASEiEB0019.
EcoGeneiEG10020. cpxR.

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034819.
InParanoidiP0AE88.
KOiK07662.
OMAiLSMIGYQ.
OrthoDBiEOG6G4VQG.
PhylomeDBiP0AE88.

Enzyme and pathway databases

BioCyciEcoCyc:CPXR-MONOMER.
ECOL316407:JW3883-MONOMER.
RETL1328306-WGS:GSTH-6652-MONOMER.

Miscellaneous databases

PROiP0AE88.

Gene expression databases

GenevestigatoriP0AE88.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The deduced amino-acid sequence of the cloned cpxR gene suggests the protein is the cognate regulator for the membrane sensor, CpxA, in a two-component signal transduction system of Escherichia coli."
    Dong J., Iuchi S., Kwan H.-S., Lu Z., Lin E.
    Gene 136:227-230(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: L547.
  2. "Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes."
    Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 21:3391-3398(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "The cpx proteins of Escherichia coli K12. Structure of the cpxA polypeptide as an inner membrane component."
    Weber R.F., Silverman P.M.
    J. Mol. Biol. 203:467-478(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-232.
    Strain: K12.

Entry informationi

Entry nameiCPXR_ECOLI
AccessioniPrimary (citable) accession number: P0AE88
Secondary accession number(s): P16244, P76777, Q2M8K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 27, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.