Transcriptional regulatory protein CpxR - Escherichia coli (strain K12)

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P0AE88 (CPXR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 75. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Transcriptional regulatory protein CpxR

Gene names

Name:	cpxR
Synonyms:	yiiA
Ordered Locus Names:	b3912, JW3883

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein.
Subcellular location	Cytoplasm Probable.
Post-translational modification	Phosphorylated by CpxA Potential.
Sequence similarities	Contains 1 response regulatory domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Two-component regulatory system
Cellular component	Cytoplasm
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: GOC negative regulation of transcription, DNA-dependent Inferred from direct assay PubMed 15686558 PubMed 16077119 PubMed 7883164 PubMed 9159398. Source: EcoCyc positive regulation of transcription, DNA-dependent Inferred from direct assay PubMed 15686558 PubMed 16077119 PubMed 7883164 PubMed 9159398. Source: EcoCyc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW phosphorelay response regulator activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 15686558 PubMed 16077119 PubMed 7883164 PubMed 9159398. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 232

232

Transcriptional regulatory protein CpxR

PRO_0000081078

Regions

Domain

1 – 115

115

Response regulatory

Amino acid modifications

Modified residue

4-aspartylphosphate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P0AE88 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 667FC2B246082F46
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FASTA

232

26,312

        10         20         30         40         50         60 
MNKILLVDDD RELTSLLKEL LEMEGFNVIV AHDGEQALDL LDDSIDLLLL DVMMPKKNGI 

        70         80         90        100        110        120 
DTLKALRQTH QTPVIMLTAR GSELDRVLGL ELGADDYLPK PFNDRELVAR IRAILRRSHW 

       130        140        150        160        170        180 
SEQQQNNDNG SPTLEVDALV LNPGRQEASF DGQTLELTGT EFTLLYLLAQ HLGQVVSREH 

       190        200        210        220        230 
LSQEVLGKRL TPFDRAIDMH ISNLRRKLPD RKDGHPWFKT LRGRGYLMVS AS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The deduced amino-acid sequence of the cloned cpxR gene suggests the protein is the cognate regulator for the membrane sensor, CpxA, in a two-component signal transduction system of Escherichia coli." Dong J., Iuchi S., Kwan H.-S., Lu Z., Lin E. Gene 136:227-230(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: L547.
[2]	"Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes." Plunkett G. III, Burland V., Daniels D.L., Blattner F.R. Nucleic Acids Res. 21:3391-3398(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"The cpx proteins of Escherichia coli K12. Structure of the cpxA polypeptide as an inner membrane component." Weber R.F., Silverman P.M. J. Mol. Biol. 203:467-478(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-232. Strain: K12.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L14579 Unassigned DNA. Translation: AAC36868.1. L19201 Genomic DNA. Translation: AAB03045.1. U00096 Genomic DNA. Translation: AAC76894.1. AP009048 Genomic DNA. Translation: BAE77397.1. X13307 Genomic DNA. Translation: CAA31686.1. M36795 Genomic DNA. Translation: AAA23599.1.
PIR	C65197.
RefSeq	NP_418348.1. NC_000913.2. YP_491538.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P0AE88.
SMR	P0AE88. Positions 3-228.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-47991N.
IntAct	P0AE88. 10 interactions.
MINT	MINT-1292432.
STRING	511145.b3912.
Proteomic databases
PaxDb	P0AE88.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC76894; AAC76894; b3912. BAE77397; BAE77397; BAE77397.
GeneID	12933651. 948404.
KEGG	ecj:Y75_p3274. eco:b3912.
PATRIC	32123337. VBIEscCol129921_4029.
Organism-specific databases
EchoBASE	EB0019.
EcoGene	EG10020. cpxR.
Phylogenomic databases
eggNOG	COG0745.
HOGENOM	HOG000034819.
KO	K07662.
OMA	YQTPVIM.
ProtClustDB	PRK10955.
Enzyme and pathway databases
BioCyc	EcoCyc:CPXR-MONOMER. ECOL316407:JW3883-MONOMER.
Gene expression databases
Genevestigator	P0AE88.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR011006. CheY-like_superfamily. IPR001867. Sig_transdc_resp-reg_C. IPR001789. Sig_transdc_resp-reg_receiver. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00072. Response_reg. 1 hit. PF00486. Trans_reg_C. 1 hit. [Graphical view]
SMART	SM00448. REC. 1 hit. SM00862. Trans_reg_C. 1 hit. [Graphical view]
SUPFAM	SSF52172. CheY_like. 1 hit.
PROSITE	PS50110. RESPONSE_REGULATORY. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CPXR_ECOLI

Accession

Primary (citable) accession number: P0AE88
Secondary accession number(s): P16244, P76777, Q2M8K9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents