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P0AE88

- CPXR_ECOLI

UniProt

P0AE88 - CPXR_ECOLI

Protein

Transcriptional regulatory protein CpxR

Gene

cpxR

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. phosphorelay response regulator activity Source: InterPro
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding transcription factor activity Source: EcoCyc

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: EcoCyc
    2. positive regulation of transcription, DNA-templated Source: CACAO
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation, Two-component regulatory system

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:CPXR-MONOMER.
    ECOL316407:JW3883-MONOMER.
    RETL1328306-WGS:GSTH-6652-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional regulatory protein CpxR
    Gene namesi
    Name:cpxR
    Synonyms:yiiA
    Ordered Locus Names:b3912, JW3883
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG10020. cpxR.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 232232Transcriptional regulatory protein CpxRPRO_0000081078Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei51 – 5114-aspartylphosphatePROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated by CpxA.Curated

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP0AE88.

    Expressioni

    Gene expression databases

    GenevestigatoriP0AE88.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    lysAP008612EBI-550918,EBI-553837

    Protein-protein interaction databases

    DIPiDIP-47991N.
    IntActiP0AE88. 11 interactions.
    MINTiMINT-1292432.
    STRINGi511145.b3912.

    Structurei

    3D structure databases

    ProteinModelPortaliP0AE88.
    SMRiP0AE88. Positions 3-228.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 115115Response regulatoryPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 response regulatory domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0745.
    HOGENOMiHOG000034819.
    KOiK07662.
    OMAiHEILSYG.
    OrthoDBiEOG6G4VQG.
    PhylomeDBiP0AE88.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view]
    SMARTiSM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52172. SSF52172. 1 hit.
    PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0AE88-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKILLVDDD RELTSLLKEL LEMEGFNVIV AHDGEQALDL LDDSIDLLLL    50
    DVMMPKKNGI DTLKALRQTH QTPVIMLTAR GSELDRVLGL ELGADDYLPK 100
    PFNDRELVAR IRAILRRSHW SEQQQNNDNG SPTLEVDALV LNPGRQEASF 150
    DGQTLELTGT EFTLLYLLAQ HLGQVVSREH LSQEVLGKRL TPFDRAIDMH 200
    ISNLRRKLPD RKDGHPWFKT LRGRGYLMVS AS 232
    Length:232
    Mass (Da):26,312
    Last modified:December 6, 2005 - v1
    Checksum:i667FC2B246082F46
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14579 Unassigned DNA. Translation: AAC36868.1.
    L19201 Genomic DNA. Translation: AAB03045.1.
    U00096 Genomic DNA. Translation: AAC76894.1.
    AP009048 Genomic DNA. Translation: BAE77397.1.
    X13307 Genomic DNA. Translation: CAA31686.1.
    M36795 Genomic DNA. Translation: AAA23599.1.
    PIRiC65197.
    RefSeqiNP_418348.1. NC_000913.3.
    YP_491538.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC76894; AAC76894; b3912.
    BAE77397; BAE77397; BAE77397.
    GeneIDi12933651.
    948404.
    KEGGiecj:Y75_p3274.
    eco:b3912.
    PATRICi32123337. VBIEscCol129921_4029.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14579 Unassigned DNA. Translation: AAC36868.1 .
    L19201 Genomic DNA. Translation: AAB03045.1 .
    U00096 Genomic DNA. Translation: AAC76894.1 .
    AP009048 Genomic DNA. Translation: BAE77397.1 .
    X13307 Genomic DNA. Translation: CAA31686.1 .
    M36795 Genomic DNA. Translation: AAA23599.1 .
    PIRi C65197.
    RefSeqi NP_418348.1. NC_000913.3.
    YP_491538.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P0AE88.
    SMRi P0AE88. Positions 3-228.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-47991N.
    IntActi P0AE88. 11 interactions.
    MINTi MINT-1292432.
    STRINGi 511145.b3912.

    Proteomic databases

    PaxDbi P0AE88.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC76894 ; AAC76894 ; b3912 .
    BAE77397 ; BAE77397 ; BAE77397 .
    GeneIDi 12933651.
    948404.
    KEGGi ecj:Y75_p3274.
    eco:b3912.
    PATRICi 32123337. VBIEscCol129921_4029.

    Organism-specific databases

    EchoBASEi EB0019.
    EcoGenei EG10020. cpxR.

    Phylogenomic databases

    eggNOGi COG0745.
    HOGENOMi HOG000034819.
    KOi K07662.
    OMAi HEILSYG.
    OrthoDBi EOG6G4VQG.
    PhylomeDBi P0AE88.

    Enzyme and pathway databases

    BioCyci EcoCyc:CPXR-MONOMER.
    ECOL316407:JW3883-MONOMER.
    RETL1328306-WGS:GSTH-6652-MONOMER.

    Miscellaneous databases

    PROi P0AE88.

    Gene expression databases

    Genevestigatori P0AE88.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view ]
    SMARTi SM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52172. SSF52172. 1 hit.
    PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The deduced amino-acid sequence of the cloned cpxR gene suggests the protein is the cognate regulator for the membrane sensor, CpxA, in a two-component signal transduction system of Escherichia coli."
      Dong J., Iuchi S., Kwan H.-S., Lu Z., Lin E.
      Gene 136:227-230(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: L547.
    2. "Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes."
      Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.
      Nucleic Acids Res. 21:3391-3398(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    5. "The cpx proteins of Escherichia coli K12. Structure of the cpxA polypeptide as an inner membrane component."
      Weber R.F., Silverman P.M.
      J. Mol. Biol. 203:467-478(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-232.
      Strain: K12.

    Entry informationi

    Entry nameiCPXR_ECOLI
    AccessioniPrimary (citable) accession number: P0AE88
    Secondary accession number(s): P16244, P76777, Q2M8K9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3