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P0AE88 (CPXR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional regulatory protein CpxR
Gene names
Name:cpxR
Synonyms:yiiA
Ordered Locus Names:b3912, JW3883
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein.

Subcellular location

Cytoplasm Probable.

Post-translational modification

Phosphorylated by CpxA Potential.

Sequence similarities

Contains 1 response regulatory domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

lysAP008612EBI-550918,EBI-553837

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 232232Transcriptional regulatory protein CpxR
PRO_0000081078

Regions

Domain1 – 115115Response regulatory

Amino acid modifications

Modified residue5114-aspartylphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
P0AE88 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 667FC2B246082F46

FASTA23226,312
        10         20         30         40         50         60 
MNKILLVDDD RELTSLLKEL LEMEGFNVIV AHDGEQALDL LDDSIDLLLL DVMMPKKNGI 

        70         80         90        100        110        120 
DTLKALRQTH QTPVIMLTAR GSELDRVLGL ELGADDYLPK PFNDRELVAR IRAILRRSHW 

       130        140        150        160        170        180 
SEQQQNNDNG SPTLEVDALV LNPGRQEASF DGQTLELTGT EFTLLYLLAQ HLGQVVSREH 

       190        200        210        220        230 
LSQEVLGKRL TPFDRAIDMH ISNLRRKLPD RKDGHPWFKT LRGRGYLMVS AS 

« Hide

References

« Hide 'large scale' references
[1]"The deduced amino-acid sequence of the cloned cpxR gene suggests the protein is the cognate regulator for the membrane sensor, CpxA, in a two-component signal transduction system of Escherichia coli."
Dong J., Iuchi S., Kwan H.-S., Lu Z., Lin E.
Gene 136:227-230(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: L547.
[2]"Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes."
Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.
Nucleic Acids Res. 21:3391-3398(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"The cpx proteins of Escherichia coli K12. Structure of the cpxA polypeptide as an inner membrane component."
Weber R.F., Silverman P.M.
J. Mol. Biol. 203:467-478(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-232.
Strain: K12.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L14579 Unassigned DNA. Translation: AAC36868.1.
L19201 Genomic DNA. Translation: AAB03045.1.
U00096 Genomic DNA. Translation: AAC76894.1.
AP009048 Genomic DNA. Translation: BAE77397.1.
X13307 Genomic DNA. Translation: CAA31686.1.
M36795 Genomic DNA. Translation: AAA23599.1.
PIRC65197.
RefSeqNP_418348.1. NC_000913.3.
YP_491538.1. NC_007779.1.

3D structure databases

ProteinModelPortalP0AE88.
SMRP0AE88. Positions 3-228.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-47991N.
IntActP0AE88. 11 interactions.
MINTMINT-1292432.
STRING511145.b3912.

Proteomic databases

PaxDbP0AE88.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC76894; AAC76894; b3912.
BAE77397; BAE77397; BAE77397.
GeneID12933651.
948404.
KEGGecj:Y75_p3274.
eco:b3912.
PATRIC32123337. VBIEscCol129921_4029.

Organism-specific databases

EchoBASEEB0019.
EcoGeneEG10020. cpxR.

Phylogenomic databases

eggNOGCOG0745.
HOGENOMHOG000034819.
KOK07662.
OMAQHQTPVI.
OrthoDBEOG6G4VQG.
PhylomeDBP0AE88.
ProtClustDBPRK10955.

Enzyme and pathway databases

BioCycEcoCyc:CPXR-MONOMER.
ECOL316407:JW3883-MONOMER.

Gene expression databases

GenevestigatorP0AE88.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMSSF52172. SSF52172. 1 hit.
PROSITEPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP0AE88.

Entry information

Entry nameCPXR_ECOLI
AccessionPrimary (citable) accession number: P0AE88
Secondary accession number(s): P16244, P76777, Q2M8K9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene