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Protein

Magnesium and cobalt efflux protein CorC

Gene

corC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the transport of magnesium and cobalt ions.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Cobalt, Magnesium

Enzyme and pathway databases

BioCyciEcoCyc:G6361-MONOMER.
ECOL316407:JW0655-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium and cobalt efflux protein CorC
Gene namesi
Name:corC
Synonyms:ybeX
Ordered Locus Names:b0658, JW0655
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13654. corC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000883451 – 292Magnesium and cobalt efflux protein CorCAdd BLAST292

Proteomic databases

PaxDbiP0AE78.
PRIDEiP0AE78.

Interactioni

Protein-protein interaction databases

BioGridi4260830. 547 interactors.
DIPiDIP-35960N.
IntActiP0AE78. 8 interactors.
STRINGi511145.b0658.

Structurei

Secondary structure

1292
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi52 – 66Combined sources15
Helixi69 – 71Combined sources3
Turni76 – 78Combined sources3
Beta strandi82 – 86Combined sources5
Helixi88 – 98Combined sources11
Beta strandi101 – 106Combined sources6
Beta strandi108 – 118Combined sources11
Helixi119 – 122Combined sources4
Turni123 – 126Combined sources4
Beta strandi144 – 146Combined sources3
Helixi151 – 161Combined sources11
Beta strandi165 – 169Combined sources5
Beta strandi175 – 180Combined sources6
Helixi181 – 189Combined sources9
Beta strandi206 – 208Combined sources3
Beta strandi211 – 215Combined sources5
Helixi220 – 227Combined sources8
Helixi239 – 247Combined sources9
Beta strandi256 – 261Combined sources6
Beta strandi263 – 269Combined sources7
Beta strandi274 – 280Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HG0X-ray3.10A1-292[»]
ProteinModelPortaliP0AE78.
SMRiP0AE78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 133CBS 1PROSITE-ProRule annotationAdd BLAST61
Domaini135 – 195CBS 2PROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the UPF0053 family.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiENOG4108JU5. Bacteria.
COG4535. LUCA.
HOGENOMiHOG000062294.
InParanoidiP0AE78.
KOiK06189.
OMAiINIADNP.
PhylomeDBiP0AE78.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF03471. CorC_HlyC. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AE78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDNSHSSD TISNKKGFFS LLLSQLFHGE PKNRDELLAL IRDSGQNDLI
60 70 80 90 100
DEDTRDMLEG VMDIADQRVR DIMIPRSQMI TLKRNQTLDE CLDVIIESAH
110 120 130 140 150
SRFPVISEDK DHIEGILMAK DLLPFMRSDA EAFSMDKVLR QAVVVPESKR
160 170 180 190 200
VDRMLKEFRS QRYHMAIVID EFGGVSGLVT IEDILELIVG EIEDEYDEED
210 220 230 240 250
DIDFRQLSRH TWTVRALASI EDFNEAFGTH FSDEEVDTIG GLVMQAFGHL
260 270 280 290
PARGETIDID GYQFKVAMAD SRRIIQVHVK IPDDSPQPKL DE
Length:292
Mass (Da):33,298
Last modified:December 6, 2005 - v1
Checksum:i7350B8B475485B32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40860.1.
U00096 Genomic DNA. Translation: AAC73759.1.
AP009048 Genomic DNA. Translation: BAA35309.2.
PIRiH64800.
RefSeqiNP_415191.1. NC_000913.3.
WP_001278605.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73759; AAC73759; b0658.
BAA35309; BAA35309; BAA35309.
GeneIDi946417.
KEGGiecj:JW0655.
eco:b0658.
PATRICi32116505. VBIEscCol129921_0692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40860.1.
U00096 Genomic DNA. Translation: AAC73759.1.
AP009048 Genomic DNA. Translation: BAA35309.2.
PIRiH64800.
RefSeqiNP_415191.1. NC_000913.3.
WP_001278605.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HG0X-ray3.10A1-292[»]
ProteinModelPortaliP0AE78.
SMRiP0AE78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260830. 547 interactors.
DIPiDIP-35960N.
IntActiP0AE78. 8 interactors.
STRINGi511145.b0658.

Proteomic databases

PaxDbiP0AE78.
PRIDEiP0AE78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73759; AAC73759; b0658.
BAA35309; BAA35309; BAA35309.
GeneIDi946417.
KEGGiecj:JW0655.
eco:b0658.
PATRICi32116505. VBIEscCol129921_0692.

Organism-specific databases

EchoBASEiEB3418.
EcoGeneiEG13654. corC.

Phylogenomic databases

eggNOGiENOG4108JU5. Bacteria.
COG4535. LUCA.
HOGENOMiHOG000062294.
InParanoidiP0AE78.
KOiK06189.
OMAiINIADNP.
PhylomeDBiP0AE78.

Enzyme and pathway databases

BioCyciEcoCyc:G6361-MONOMER.
ECOL316407:JW0655-MONOMER.

Miscellaneous databases

PROiP0AE78.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF03471. CorC_HlyC. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCORC_ECOLI
AccessioniPrimary (citable) accession number: P0AE78
Secondary accession number(s): P77392
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.