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P0AE78

- CORC_ECOLI

UniProt

P0AE78 - CORC_ECOLI

Protein

Magnesium and cobalt efflux protein CorC

Gene

corC

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Plays a role in the transport of magnesium and cobalt ions.By similarity

    GO - Molecular functioni

    1. adenyl nucleotide binding Source: InterPro
    2. flavin adenine dinucleotide binding Source: InterPro
    3. oxidoreductase activity, acting on CH-OH group of donors Source: InterPro

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Cobalt, Magnesium

    Enzyme and pathway databases

    BioCyciEcoCyc:G6361-MONOMER.
    ECOL316407:JW0655-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Magnesium and cobalt efflux protein CorC
    Gene namesi
    Name:corC
    Synonyms:ybeX
    Ordered Locus Names:b0658, JW0655
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13654. corC.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Magnesium and cobalt efflux protein CorCPRO_0000088345Add
    BLAST

    Proteomic databases

    PaxDbiP0AE78.
    PRIDEiP0AE78.

    Expressioni

    Gene expression databases

    GenevestigatoriP0AE78.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-35960N.
    IntActiP0AE78. 8 interactions.
    STRINGi511145.b0658.

    Structurei

    Secondary structure

    1
    292
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi52 – 6615
    Helixi69 – 713
    Turni76 – 783
    Beta strandi82 – 865
    Helixi88 – 9811
    Beta strandi101 – 1066
    Beta strandi108 – 11811
    Helixi119 – 1224
    Turni123 – 1264
    Beta strandi144 – 1463
    Helixi151 – 16111
    Beta strandi165 – 1695
    Beta strandi175 – 1806
    Helixi181 – 1899
    Beta strandi206 – 2083
    Beta strandi211 – 2155
    Helixi220 – 2278
    Helixi239 – 2479
    Beta strandi256 – 2616
    Beta strandi263 – 2697
    Beta strandi274 – 2807

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HG0X-ray3.10A1-292[»]
    ProteinModelPortaliP0AE78.
    SMRiP0AE78. Positions 51-282.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini73 – 13361CBS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini135 – 19561CBS 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UPF0053 family.Curated
    Contains 2 CBS domains.PROSITE-ProRule annotation

    Keywords - Domaini

    CBS domain, Repeat

    Phylogenomic databases

    eggNOGiCOG4535.
    HOGENOMiHOG000062294.
    KOiK06189.
    OMAiPSSKKGF.
    OrthoDBiEOG60W7V4.
    PhylomeDBiP0AE78.

    Family and domain databases

    Gene3Di3.30.465.10. 1 hit.
    InterProiIPR000644. CBS_dom.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR005170. Transptr-assoc_dom.
    [Graphical view]
    PfamiPF00571. CBS. 2 hits.
    PF03471. CorC_HlyC. 1 hit.
    [Graphical view]
    SMARTiSM00116. CBS. 2 hits.
    SM01091. CorC_HlyC. 1 hit.
    [Graphical view]
    SUPFAMiSSF56176. SSF56176. 1 hit.
    PROSITEiPS51371. CBS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0AE78-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDDNSHSSD TISNKKGFFS LLLSQLFHGE PKNRDELLAL IRDSGQNDLI    50
    DEDTRDMLEG VMDIADQRVR DIMIPRSQMI TLKRNQTLDE CLDVIIESAH 100
    SRFPVISEDK DHIEGILMAK DLLPFMRSDA EAFSMDKVLR QAVVVPESKR 150
    VDRMLKEFRS QRYHMAIVID EFGGVSGLVT IEDILELIVG EIEDEYDEED 200
    DIDFRQLSRH TWTVRALASI EDFNEAFGTH FSDEEVDTIG GLVMQAFGHL 250
    PARGETIDID GYQFKVAMAD SRRIIQVHVK IPDDSPQPKL DE 292
    Length:292
    Mass (Da):33,298
    Last modified:December 6, 2005 - v1
    Checksum:i7350B8B475485B32
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82598 Genomic DNA. Translation: AAB40860.1.
    U00096 Genomic DNA. Translation: AAC73759.1.
    AP009048 Genomic DNA. Translation: BAA35309.2.
    PIRiH64800.
    RefSeqiNP_415191.1. NC_000913.3.
    YP_488949.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC73759; AAC73759; b0658.
    BAA35309; BAA35309; BAA35309.
    GeneIDi12931836.
    946417.
    KEGGiecj:Y75_p0648.
    eco:b0658.
    PATRICi32116505. VBIEscCol129921_0692.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82598 Genomic DNA. Translation: AAB40860.1 .
    U00096 Genomic DNA. Translation: AAC73759.1 .
    AP009048 Genomic DNA. Translation: BAA35309.2 .
    PIRi H64800.
    RefSeqi NP_415191.1. NC_000913.3.
    YP_488949.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HG0 X-ray 3.10 A 1-292 [» ]
    ProteinModelPortali P0AE78.
    SMRi P0AE78. Positions 51-282.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-35960N.
    IntActi P0AE78. 8 interactions.
    STRINGi 511145.b0658.

    Proteomic databases

    PaxDbi P0AE78.
    PRIDEi P0AE78.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC73759 ; AAC73759 ; b0658 .
    BAA35309 ; BAA35309 ; BAA35309 .
    GeneIDi 12931836.
    946417.
    KEGGi ecj:Y75_p0648.
    eco:b0658.
    PATRICi 32116505. VBIEscCol129921_0692.

    Organism-specific databases

    EchoBASEi EB3418.
    EcoGenei EG13654. corC.

    Phylogenomic databases

    eggNOGi COG4535.
    HOGENOMi HOG000062294.
    KOi K06189.
    OMAi PSSKKGF.
    OrthoDBi EOG60W7V4.
    PhylomeDBi P0AE78.

    Enzyme and pathway databases

    BioCyci EcoCyc:G6361-MONOMER.
    ECOL316407:JW0655-MONOMER.

    Miscellaneous databases

    PROi P0AE78.

    Gene expression databases

    Genevestigatori P0AE78.

    Family and domain databases

    Gene3Di 3.30.465.10. 1 hit.
    InterProi IPR000644. CBS_dom.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR005170. Transptr-assoc_dom.
    [Graphical view ]
    Pfami PF00571. CBS. 2 hits.
    PF03471. CorC_HlyC. 1 hit.
    [Graphical view ]
    SMARTi SM00116. CBS. 2 hits.
    SM01091. CorC_HlyC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56176. SSF56176. 1 hit.
    PROSITEi PS51371. CBS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    2. "Sequence of minutes 4-25 of Escherichia coli."
      Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiCORC_ECOLI
    AccessioniPrimary (citable) accession number: P0AE78
    Secondary accession number(s): P77392
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3