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Protein

Magnesium and cobalt efflux protein CorC

Gene

corC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the transport of magnesium and cobalt ions.By similarity

GO - Molecular functioni

  1. adenyl nucleotide binding Source: InterPro
  2. flavin adenine dinucleotide binding Source: InterPro
  3. oxidoreductase activity, acting on CH-OH group of donors Source: InterPro

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Cobalt, Magnesium

Enzyme and pathway databases

BioCyciEcoCyc:G6361-MONOMER.
ECOL316407:JW0655-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium and cobalt efflux protein CorC
Gene namesi
Name:corC
Synonyms:ybeX
Ordered Locus Names:b0658, JW0655
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13654. corC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Magnesium and cobalt efflux protein CorCPRO_0000088345Add
BLAST

Proteomic databases

PaxDbiP0AE78.
PRIDEiP0AE78.

Expressioni

Gene expression databases

GenevestigatoriP0AE78.

Interactioni

Protein-protein interaction databases

DIPiDIP-35960N.
IntActiP0AE78. 8 interactions.
STRINGi511145.b0658.

Structurei

Secondary structure

1
292
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi52 – 6615Combined sources
Helixi69 – 713Combined sources
Turni76 – 783Combined sources
Beta strandi82 – 865Combined sources
Helixi88 – 9811Combined sources
Beta strandi101 – 1066Combined sources
Beta strandi108 – 11811Combined sources
Helixi119 – 1224Combined sources
Turni123 – 1264Combined sources
Beta strandi144 – 1463Combined sources
Helixi151 – 16111Combined sources
Beta strandi165 – 1695Combined sources
Beta strandi175 – 1806Combined sources
Helixi181 – 1899Combined sources
Beta strandi206 – 2083Combined sources
Beta strandi211 – 2155Combined sources
Helixi220 – 2278Combined sources
Helixi239 – 2479Combined sources
Beta strandi256 – 2616Combined sources
Beta strandi263 – 2697Combined sources
Beta strandi274 – 2807Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HG0X-ray3.10A1-292[»]
ProteinModelPortaliP0AE78.
SMRiP0AE78. Positions 51-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini73 – 13361CBS 1PROSITE-ProRule annotationAdd
BLAST
Domaini135 – 19561CBS 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0053 family.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiCOG4535.
HOGENOMiHOG000062294.
InParanoidiP0AE78.
KOiK06189.
OMAiHIRTILR.
OrthoDBiEOG60W7V4.
PhylomeDBiP0AE78.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF03471. CorC_HlyC. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AE78-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDDNSHSSD TISNKKGFFS LLLSQLFHGE PKNRDELLAL IRDSGQNDLI
60 70 80 90 100
DEDTRDMLEG VMDIADQRVR DIMIPRSQMI TLKRNQTLDE CLDVIIESAH
110 120 130 140 150
SRFPVISEDK DHIEGILMAK DLLPFMRSDA EAFSMDKVLR QAVVVPESKR
160 170 180 190 200
VDRMLKEFRS QRYHMAIVID EFGGVSGLVT IEDILELIVG EIEDEYDEED
210 220 230 240 250
DIDFRQLSRH TWTVRALASI EDFNEAFGTH FSDEEVDTIG GLVMQAFGHL
260 270 280 290
PARGETIDID GYQFKVAMAD SRRIIQVHVK IPDDSPQPKL DE
Length:292
Mass (Da):33,298
Last modified:December 6, 2005 - v1
Checksum:i7350B8B475485B32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40860.1.
U00096 Genomic DNA. Translation: AAC73759.1.
AP009048 Genomic DNA. Translation: BAA35309.2.
PIRiH64800.
RefSeqiNP_415191.1. NC_000913.3.
YP_488949.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73759; AAC73759; b0658.
BAA35309; BAA35309; BAA35309.
GeneIDi12931836.
946417.
KEGGiecj:Y75_p0648.
eco:b0658.
PATRICi32116505. VBIEscCol129921_0692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40860.1.
U00096 Genomic DNA. Translation: AAC73759.1.
AP009048 Genomic DNA. Translation: BAA35309.2.
PIRiH64800.
RefSeqiNP_415191.1. NC_000913.3.
YP_488949.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HG0X-ray3.10A1-292[»]
ProteinModelPortaliP0AE78.
SMRiP0AE78. Positions 51-282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-35960N.
IntActiP0AE78. 8 interactions.
STRINGi511145.b0658.

Proteomic databases

PaxDbiP0AE78.
PRIDEiP0AE78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73759; AAC73759; b0658.
BAA35309; BAA35309; BAA35309.
GeneIDi12931836.
946417.
KEGGiecj:Y75_p0648.
eco:b0658.
PATRICi32116505. VBIEscCol129921_0692.

Organism-specific databases

EchoBASEiEB3418.
EcoGeneiEG13654. corC.

Phylogenomic databases

eggNOGiCOG4535.
HOGENOMiHOG000062294.
InParanoidiP0AE78.
KOiK06189.
OMAiHIRTILR.
OrthoDBiEOG60W7V4.
PhylomeDBiP0AE78.

Enzyme and pathway databases

BioCyciEcoCyc:G6361-MONOMER.
ECOL316407:JW0655-MONOMER.

Miscellaneous databases

PROiP0AE78.

Gene expression databases

GenevestigatoriP0AE78.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF03471. CorC_HlyC. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiCORC_ECOLI
AccessioniPrimary (citable) accession number: P0AE78
Secondary accession number(s): P77392
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: January 7, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.