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Protein

Citrate carrier

Gene

citT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the uptake of citrate in exchange to the efflux of succinate. Has a relatively broad specificity for C(4)-dicarboxylates and tricarboxylates.

GO - Molecular functioni

  • antiporter activity Source: UniProtKB-KW
  • transporter activity Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:B0612-MONOMER.
ECOL316407:JW0604-MONOMER.
MetaCyc:B0612-MONOMER.

Protein family/group databases

TCDBi2.A.47.3.2. the divalent anion:na(+) symporter (dass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate carrier
Alternative name(s):
Citrate transporter
Citrate/succinate antiporter
Gene namesi
Name:citT
Synonyms:ybdS
Ordered Locus Names:b0612, JW0604
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13538. citT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence analysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence analysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence analysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence analysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence analysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence analysisAdd
BLAST
Transmembranei309 – 32921HelicalSequence analysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence analysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence analysisAdd
BLAST
Transmembranei401 – 42121HelicalSequence analysisAdd
BLAST
Transmembranei424 – 44421HelicalSequence analysisAdd
BLAST
Transmembranei463 – 48321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487Citrate carrierPRO_0000172521Add
BLAST

Proteomic databases

PaxDbiP0AE74.

Interactioni

Protein-protein interaction databases

BioGridi4259902. 3 interactions.
STRINGi511145.b0612.

Structurei

3D structure databases

ProteinModelPortaliP0AE74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QPK. Bacteria.
COG0471. LUCA.
HOGENOMiHOG000117911.
InParanoidiP0AE74.
KOiK09477.
OMAiTMSAHLE.
OrthoDBiEOG6WT8FN.
PhylomeDBiP0AE74.

Family and domain databases

InterProiIPR030676. CitT-rel.
IPR001898. Na/sul_symport.
[Graphical view]
PANTHERiPTHR10283:SF13. PTHR10283:SF13. 2 hits.
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PIRSFiPIRSF002457. DASS. 1 hit.
TIGRFAMsiTIGR00785. dass. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AE74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLAKDNIWK LLAPLVVMGV MFLIPVPDGM PPQAWHYFAV FVAMIVGMIL
60 70 80 90 100
EPIPATAISF IAVTICVIGS NYLLFDAKEL ADPAFNAQKQ ALKWGLAGFS
110 120 130 140 150
STTVWLVFGA FIFALGYEVS GLGRRIALFL VKFMGKRTLT LGYAIVIIDI
160 170 180 190 200
LLAPFTPSNT ARTGGTVFPV IKNLPPLFKS FPNDPSARRI GGYLMWMMVI
210 220 230 240 250
STSLSSSMFV TGAAPNVLGL EFVSKIAGIQ ISWLQWFLCF LPVGVILLII
260 270 280 290 300
APWLSYVLYK PEITHSEEVA TWAGDELKTM GALTRREWTL IGLVLLSLGL
310 320 330 340 350
WVFGSEVINA TAVGLLAVSL MLALHVVPWK DITRYNSAWN TLVNLATLVV
360 370 380 390 400
MANGLTRSGF IDWFAGTMST HLEGFSPNAT VIVLVLVFYF AHYLFASLSA
410 420 430 440 450
HTATMLPVIL AVGKGIPGVP MEQLCILLVL SIGIMGCLTP YATGPGVIIY
460 470 480
GCGYVKSKDY WRLGAIFGVI YISMLLLVGW PILAMWN
Length:487
Mass (Da):53,093
Last modified:December 6, 2005 - v1
Checksum:i9AD55B9E7448F1DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40812.1.
U00096 Genomic DNA. Translation: AAC73713.1.
AP009048 Genomic DNA. Translation: BAA35241.1.
PIRiB64795.
RefSeqiNP_415145.1. NC_000913.3.
WP_000050323.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73713; AAC73713; b0612.
BAA35241; BAA35241; BAA35241.
GeneIDi949070.
KEGGiecj:JW0604.
eco:b0612.
PATRICi32116404. VBIEscCol129921_0642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40812.1.
U00096 Genomic DNA. Translation: AAC73713.1.
AP009048 Genomic DNA. Translation: BAA35241.1.
PIRiB64795.
RefSeqiNP_415145.1. NC_000913.3.
WP_000050323.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AE74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259902. 3 interactions.
STRINGi511145.b0612.

Protein family/group databases

TCDBi2.A.47.3.2. the divalent anion:na(+) symporter (dass) family.

Proteomic databases

PaxDbiP0AE74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73713; AAC73713; b0612.
BAA35241; BAA35241; BAA35241.
GeneIDi949070.
KEGGiecj:JW0604.
eco:b0612.
PATRICi32116404. VBIEscCol129921_0642.

Organism-specific databases

EchoBASEiEB3308.
EcoGeneiEG13538. citT.

Phylogenomic databases

eggNOGiENOG4107QPK. Bacteria.
COG0471. LUCA.
HOGENOMiHOG000117911.
InParanoidiP0AE74.
KOiK09477.
OMAiTMSAHLE.
OrthoDBiEOG6WT8FN.
PhylomeDBiP0AE74.

Enzyme and pathway databases

BioCyciEcoCyc:B0612-MONOMER.
ECOL316407:JW0604-MONOMER.
MetaCyc:B0612-MONOMER.

Miscellaneous databases

PROiP0AE74.

Family and domain databases

InterProiIPR030676. CitT-rel.
IPR001898. Na/sul_symport.
[Graphical view]
PANTHERiPTHR10283:SF13. PTHR10283:SF13. 2 hits.
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PIRSFiPIRSF002457. DASS. 1 hit.
TIGRFAMsiTIGR00785. dass. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "The Escherichia coli citrate carrier CitT: a member of a novel eubacterial transporter family related to the 2-oxoglutarate/malate translocator from spinach chloroplasts."
    Pos K.M., Dimroth P., Bott M.
    J. Bacteriol. 180:4160-4165(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiCITT_ECOLI
AccessioniPrimary (citable) accession number: P0AE74
Secondary accession number(s): P77405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: February 17, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.