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Protein

Citrate/succinate antiporter

Gene

citT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for the uptake of citrate in exchange with the efflux of succinate, fumarate or tartrate. Has a relatively broad specificity for C4-dicarboxylates and tricarboxylates (PubMed:9696764).1 Publication

GO - Molecular functioni

  • antiporter activity Source: UniProtKB-KW
  • transporter activity Source: EcoCyc

GO - Biological processi

Keywordsi

Biological processAntiport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:B0612-MONOMER
MetaCyc:B0612-MONOMER

Protein family/group databases

TCDBi2.A.47.3.2 the divalent anion:na(+) symporter (dass) family

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate/succinate antiporter
Alternative name(s):
Citrate carrier
Citrate transporter
Gene namesi
Name:citT
Synonyms:ybdS
Ordered Locus Names:b0612, JW0604
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13538 citT

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Transmembranei463 – 483HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001725211 – 487Citrate/succinate antiporterAdd BLAST487

Proteomic databases

PaxDbiP0AE74
PRIDEiP0AE74

Interactioni

Protein-protein interaction databases

BioGridi4259902, 6 interactors
STRINGi316385.ECDH10B_0680

Structurei

3D structure databases

ProteinModelPortaliP0AE74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QPK Bacteria
COG0471 LUCA
HOGENOMiHOG000117911
InParanoidiP0AE74
KOiK09477
OMAiPQAWRYF
PhylomeDBiP0AE74

Family and domain databases

InterProiView protein in InterPro
IPR030676 CitT-rel
IPR001898 SLC13A/DASS
PANTHERiPTHR42826 PTHR42826, 1 hit
PfamiView protein in Pfam
PF00939 Na_sulph_symp, 1 hit
PIRSFiPIRSF002457 DASS, 1 hit
TIGRFAMsiTIGR00785 dass, 1 hit

Sequencei

Sequence statusi: Complete.

P0AE74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLAKDNIWK LLAPLVVMGV MFLIPVPDGM PPQAWHYFAV FVAMIVGMIL
60 70 80 90 100
EPIPATAISF IAVTICVIGS NYLLFDAKEL ADPAFNAQKQ ALKWGLAGFS
110 120 130 140 150
STTVWLVFGA FIFALGYEVS GLGRRIALFL VKFMGKRTLT LGYAIVIIDI
160 170 180 190 200
LLAPFTPSNT ARTGGTVFPV IKNLPPLFKS FPNDPSARRI GGYLMWMMVI
210 220 230 240 250
STSLSSSMFV TGAAPNVLGL EFVSKIAGIQ ISWLQWFLCF LPVGVILLII
260 270 280 290 300
APWLSYVLYK PEITHSEEVA TWAGDELKTM GALTRREWTL IGLVLLSLGL
310 320 330 340 350
WVFGSEVINA TAVGLLAVSL MLALHVVPWK DITRYNSAWN TLVNLATLVV
360 370 380 390 400
MANGLTRSGF IDWFAGTMST HLEGFSPNAT VIVLVLVFYF AHYLFASLSA
410 420 430 440 450
HTATMLPVIL AVGKGIPGVP MEQLCILLVL SIGIMGCLTP YATGPGVIIY
460 470 480
GCGYVKSKDY WRLGAIFGVI YISMLLLVGW PILAMWN
Length:487
Mass (Da):53,093
Last modified:December 6, 2005 - v1
Checksum:i9AD55B9E7448F1DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA Translation: AAB40812.1
U00096 Genomic DNA Translation: AAC73713.1
AP009048 Genomic DNA Translation: BAA35241.1
PIRiB64795
RefSeqiNP_415145.1, NC_000913.3
WP_000050323.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73713; AAC73713; b0612
BAA35241; BAA35241; BAA35241
GeneIDi949070
KEGGiecj:JW0604
eco:b0612
PATRICifig|1411691.4.peg.1656

Similar proteinsi

Entry informationi

Entry nameiCITT_ECOLI
AccessioniPrimary (citable) accession number: P0AE74
Secondary accession number(s): P77405
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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