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Protein

Cell division activator CedA

Gene

cedA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Activates the cell division inhibited by chromosomal DNA over-replication.

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-HAMAP
  • regulation of cell division Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6936-MONOMER.
ECOL316407:JW1720-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division activator CedA
Gene namesi
Name:cedA
Synonyms:ydjP
Ordered Locus Names:b1731, JW1720
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13992. cedA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8080Cell division activator CedAPRO_0000089471Add
BLAST

Proteomic databases

PaxDbiP0AE60.

Interactioni

Protein-protein interaction databases

BioGridi4260304. 400 interactions.
DIPiDIP-47928N.
IntActiP0AE60. 14 interactions.
STRINGi511145.b1731.

Structurei

Secondary structure

1
80
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni30 – 323Combined sources
Beta strandi36 – 394Combined sources
Beta strandi42 – 465Combined sources
Beta strandi49 – 513Combined sources
Beta strandi53 – 553Combined sources
Beta strandi59 – 613Combined sources
Helixi62 – 7413Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BN8NMR-A1-80[»]
2D35NMR-A19-80[»]
ProteinModelPortaliP0AE60.
SMRiP0AE60. Positions 14-80.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AE60.

Family & Domainsi

Sequence similaritiesi

Belongs to the CedA family.Curated

Phylogenomic databases

eggNOGiENOG4105R8J. Bacteria.
ENOG4111YYN. LUCA.
HOGENOMiHOG000267901.
KOiK15722.
OMAiQNRPVIS.
OrthoDBiEOG6PS5XM.

Family and domain databases

HAMAPiMF_01580. CedA.
InterProiIPR019666. Cell_div_activator_CedA.
[Graphical view]
PfamiPF10729. CedA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AE60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKPLRQQNR QIISYVPRTE PAPPEHAIKM DSFRDVWMLR GKYVAFVLMG
60 70 80
ESFLRSPAFT VPESAQRWAN QIRQEGEVTE
Length:80
Mass (Da):9,377
Last modified:June 12, 2007 - v2
Checksum:i69CFC7E3EF709D72
GO

Sequence cautioni

The sequence BAE76513.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74801.2.
AP009048 Genomic DNA. Translation: BAE76513.1. Different initiation.
PIRiC64932.
RefSeqiNP_416245.2. NC_000913.3.
WP_001295480.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74801; AAC74801; b1731.
BAE76513; BAE76513; BAE76513.
GeneIDi946235.
KEGGiecj:JW1720.
eco:b1731.
PATRICi32118769. VBIEscCol129921_1802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74801.2.
AP009048 Genomic DNA. Translation: BAE76513.1. Different initiation.
PIRiC64932.
RefSeqiNP_416245.2. NC_000913.3.
WP_001295480.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BN8NMR-A1-80[»]
2D35NMR-A19-80[»]
ProteinModelPortaliP0AE60.
SMRiP0AE60. Positions 14-80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260304. 400 interactions.
DIPiDIP-47928N.
IntActiP0AE60. 14 interactions.
STRINGi511145.b1731.

Proteomic databases

PaxDbiP0AE60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74801; AAC74801; b1731.
BAE76513; BAE76513; BAE76513.
GeneIDi946235.
KEGGiecj:JW1720.
eco:b1731.
PATRICi32118769. VBIEscCol129921_1802.

Organism-specific databases

EchoBASEiEB3748.
EcoGeneiEG13992. cedA.

Phylogenomic databases

eggNOGiENOG4105R8J. Bacteria.
ENOG4111YYN. LUCA.
HOGENOMiHOG000267901.
KOiK15722.
OMAiQNRPVIS.
OrthoDBiEOG6PS5XM.

Enzyme and pathway databases

BioCyciEcoCyc:G6936-MONOMER.
ECOL316407:JW1720-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0AE60.
PROiP0AE60.

Family and domain databases

HAMAPiMF_01580. CedA.
InterProiIPR019666. Cell_div_activator_CedA.
[Graphical view]
PfamiPF10729. CedA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "CedA is a novel Escherichia coli protein that activates the cell division inhibited by chromosomal DNA over-replication."
    Katayama T., Takata M., Sekimizu K.
    Mol. Microbiol. 26:687-697(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. "Solution structure and interactions of the Escherichia coli cell division activator protein CedA."
    Chen H.A., Simpson P., Huyton T., Roper D., Matthews S.
    Biochemistry 44:6738-6744(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, DNA-BINDING.
  5. "Structural analysis and molecular interaction of cell division reactivation factor, cedA from Escherichia coli."
    Abe Y., Watanabe N., Matsuda Y., Yoshida Y., Katayama T., Ueda T.
    Submitted (SEP-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 19-80.

Entry informationi

Entry nameiCEDA_ECOLI
AccessioniPrimary (citable) accession number: P0AE60
Secondary accession number(s): P76211, Q2MB43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 12, 2007
Last modified: July 6, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

In vitro, binds double-stranded DNA, but not single-stranded DNA.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.