P0AE58 (CAIF_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcriptional activatory protein CaiF

Gene names

Name:	caiF
Ordered Locus Names:	b0034, JW0033

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function

Potential transcriptional activator of carnitine metabolism.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carnitine metabolic process Inferred from experiment Ref.1. Source: EcoliWiki transcription, DNA-dependent Inferred from direct assay PubMed 10564497. Source: EcoCyc
Molecular_function	carnitine dehydratase activity Inferred from direct assay Ref.1. Source: EcoliWiki sequence-specific DNA binding transcription factor activity Inferred from direct assay Ref.1. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 131	131	Transcriptional activatory protein CaiF		PRO_0000089284

Sequences

	Sequence		Length	Mass (Da)
	P0AE58 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: D2315E9DEBF976BD	FASTA	131	15,436
	10 20 30 40 50 60 MCEGYVEKPL YLLIAEWMMA ENRWVIAREI SIHFDIEHSK AVNTLTYILS EVTEISCEVK 70 80 90 100 110 120 MIPNKLEGRG CQCQRLVKVV DIDEQIYARL RNNSREKLVG VRKTPRIPAV PLTELNREQK 130 WQMMLSKSMR R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of the caiF gene encoding a potential transcriptional activator of carnitine metabolism in Escherichia coli." Eichler K., Buchet A., Lemke R., Kleber H.-P., Mandrand-Berthelot M.-A. J. Bacteriol. 178:1248-1257(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: O44:K74.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X80644 Genomic DNA. Translation: CAA56690.1. U00096 Genomic DNA. Translation: AAC73145.2. AP009048 Genomic DNA. Translation: BAE76036.1.
RefSeq	NP_414576.4. NC_000913.2. YP_488340.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P0AE58.
ModBase	Search...
Protein-protein interaction databases
IntAct	P0AE58. 5 interactions.
STRING	511145.b0034.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC73145; AAC73145; b0034. BAE76036; BAE76036; BAE76036.
GeneID	12934352. 944795.
KEGG	ecj:Y75_p0034. eco:b0034.
PATRIC	32115163. VBIEscCol129921_0033.
Organism-specific databases
EchoBASE	EB3224.
EcoGene	EG13451. caiF.
Phylogenomic databases
eggNOG	NOG12280.
HOGENOM	HOG000116723.
KO	K08277.
OMA	TIPNQLE.
ProtClustDB	PRK11476.
Enzyme and pathway databases
BioCyc	EcoCyc:G6088-MONOMER. ECOL316407:JW0033-MONOMER.
Gene expression databases
Genevestigator	P0AE58.
Family and domain databases
InterPro	IPR020357. Tscrpt_reg_CaiF. [Graphical view]
Pfam	PF07180. DUF1401. 1 hit. [Graphical view]
ProDom	PD081346. Transcription_activatory_CaiF. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

CAIF_ECOLI

Accession

Primary (citable) accession number: P0AE58
Secondary accession number(s): P75622, Q2MCH0, Q47081

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program