ID   BCP_ECOLI               Reviewed;         156 AA.
AC   P0AE52; P23480;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=Putative peroxiredoxin bcp;
DE            EC=1.11.1.15;
DE   AltName: Full=Thioredoxin reductase;
DE   AltName: Full=Bacterioferritin comigratory protein;
GN   Name=bcp; OrderedLocusNames=b2480, JW2465;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   MEDLINE=91202105; PubMed=2016588;
RA   Andrews S.C., Harrison P.M., Guest J.R.;
RT   "A molecular analysis of the 53.3 minute region of the Escherichia
RT   coli linkage map.";
RL   J. Gen. Microbiol. 137:361-367(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   MEDLINE=97349980; PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA   Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K.,
RA   Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N.,
RA   Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H.,
RA   Oshima T., Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S.,
RA   Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C.,
RA   Yamagata S., Horiuchi T.;
RT   "Construction of a contiguous 874-kb sequence of the Escherichia coli-
RT   K12 genome corresponding to 50.0-68.8 min on the linkage map and
RT   analysis of its sequence features.";
RL   DNA Res. 4:91-113(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA   Mau B., Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1474(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains
RT   MG1655 and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
RC   STRAIN=K12;
RX   MEDLINE=98196724; PubMed=9537378;
RA   Ghrist A.C., Stauffer G.V.;
RT   "Promoter characterization and constitutive expression of the
RT   Escherichia coli gcvR gene.";
RL   J. Bacteriol. 180:1803-1807(1998).
RN   [6]
RP   PROTEIN SEQUENCE OF 1-15.
RC   STRAIN=K12 / EMG2;
RX   MEDLINE=97443975; PubMed=9298646; DOI=10.1002/elps.1150180807;
RA   Link A.J., Robison K., Church G.M.;
RT   "Comparing the predicted and observed properties of proteins encoded
RT   in the genome of Escherichia coli K-12.";
RL   Electrophoresis 18:1259-1313(1997).
RN   [7]
RP   PROTEIN SEQUENCE OF 1-11.
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA   Frutiger S., Hughes G.J., Pasquali C., Hochstrasser D.F.;
RL   Submitted (FEB-1996) to UniProtKB.
RN   [8]
RP   ACTIVE SITE CYS-46.
RX   PubMed=10644761; DOI=10.1074/jbc.275.4.2924;
RA   Jeong W., Cha M.K., Kim I.H.;
RT   "Thioredoxin-dependent hydroperoxide peroxidase activity of
RT   bacterioferritin comigratory protein (BCP) as a new member of the
RT   thiol-specific antioxidant protein (TSA)/Alkyl hydroperoxide
RT   peroxidase C (AhpC) family.";
RL   J. Biol. Chem. 275:2924-2930(2000).
CC   -!- CATALYTIC ACTIVITY: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
CC   -!- SIMILARITY: Belongs to the ahpC/TSA family.
CC   -!- SIMILARITY: Contains 1 thioredoxin domain.
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DR   EMBL; M63654; AAB88562.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC75533.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA16358.1; -; Genomic_DNA.
DR   EMBL; AF023337; AAC46233.1; -; Genomic_DNA.
DR   PIR; B49749; B49749.
DR   RefSeq; AP_003066.1; -.
DR   RefSeq; NP_416975.1; -.
DR   SWISS-2DPAGE; P0AE52; -.
DR   GeneID; 946949; -.
DR   GenomeReviews; AP009048_GR; JW2465.
DR   GenomeReviews; U00096_GR; b2480.
DR   KEGG; ecj:JW2465; -.
DR   KEGG; eco:b2480; -.
DR   EchoBASE; EB0106; -.
DR   EcoGene; EG10108; bcp.
DR   HOGENOM; P0AE52; -.
DR   OMA; P0AE52; LRDNMDD.
DR   BioCyc; EcoCyc:EG10108-MON; -.
DR   BioCyc; MetaCyc:EG10108-MON; -.
DR   GO; GO:0051920; F:peroxiredoxin activity; IEA:EC.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000866; Alkyl_hydroperoxide_Rdtase.
DR   InterPro; IPR017936; Thioredoxin-like.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   Pfam; PF00578; AhpC-TSA; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Direct protein sequencing; Oxidoreductase;
KW   Peroxidase; Redox-active center.
FT   CHAIN         1    156       Putative peroxiredoxin bcp.
FT                                /FTId=PRO_0000135134.
FT   DOMAIN        4    156       Thioredoxin.
FT   ACT_SITE     46     46       Cysteine sulfenic acid (-SOH)
FT                                intermediate.
SQ   SEQUENCE   156 AA;  17634 MW;  C7D267A671409EFC CRC64;
     MNPLKAGDIA PKFSLPDQDG EQVNLTDFQG QRVLVYFYPK AMTPGCTVQA CGLRDNMDEL
     KKAGVDVLGI STDKPEKLSR FAEKELLNFT LLSDEDHQVC EQFGVWGEKS FMGKTYDGIH
     RISFLIDADG KIEHVFDDFK TSNHHDVVLN WLKEHA
//