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Reviewed, UniProtKB/Swiss-Prot P0AE52 (BCP_ECOLI)

Last modified November 25, 2008. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Putative peroxiredoxin bcp
    EC=1.11.1.15
Alternative name(s):
    Thioredoxin reductase
    Bacterioferritin comigratory protein
Gene names
Name: bcp
Ordered Locus Names: b2480, JW2465
OrganismEscherichia coli (strain K12) [Complete proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length156 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.

Sequence similarities

Belongs to the ahpC/TSA family.

Contains 1 thioredoxin domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 156156Putative peroxiredoxin bcp
PRO_0000135134

Regions

Domain4 – 156153Thioredoxin

Sites

Active site461Cysteine sulfenic acid (-SOH) intermediate

Sequences

Sequence LengthMass (Da)Tools
P0AE52-1 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: C7D267A671409EFC

FASTA15617,634
        10         20         30         40         50         60 
MNPLKAGDIA PKFSLPDQDG EQVNLTDFQG QRVLVYFYPK AMTPGCTVQA CGLRDNMDEL 

        70         80         90        100        110        120 
KKAGVDVLGI STDKPEKLSR FAEKELLNFT LLSDEDHQVC EQFGVWGEKS FMGKTYDGIH 

       130        140        150 
RISFLIDADG KIEHVFDDFK TSNHHDVVLN WLKEHA 

« Hide

References

« Hide 'large scale' references
[1]"A molecular analysis of the 53.3 minute region of the Escherichia coli linkage map."
Andrews S.C., Harrison P.M., Guest J.R.
J. Gen. Microbiol. 137:361-367(1991) [PubMed: 2016588] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T. expand/collapse author list , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
DNA Res. 4:91-113(1997) [PubMed: 9205837] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"Promoter characterization and constitutive expression of the Escherichia coli gcvR gene."
Ghrist A.C., Stauffer G.V.
J. Bacteriol. 180:1803-1807(1998) [PubMed: 9537378] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
Strain: K12.
[6]"Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12."
Link A.J., Robison K., Church G.M.
Electrophoresis 18:1259-1313(1997) [PubMed: 9298646] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-15.
Strain: K12 / EMG2.
[7]Frutiger S., Hughes G.J., Pasquali C., Hochstrasser D.F.
Submitted (FEB-1996) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 1-11.
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[8]"Thioredoxin-dependent hydroperoxide peroxidase activity of bacterioferritin comigratory protein (BCP) as a new member of the thiol-specific antioxidant protein (TSA)/Alkyl hydroperoxide peroxidase C (AhpC) family."
Jeong W., Cha M.K., Kim I.H.
J. Biol. Chem. 275:2924-2930(2000) [PubMed: 10644761] [Abstract]
Cited for: ACTIVE SITE CYS-46.

Cross-references

Sequence databases

M63654 Genomic DNA. Translation: AAB88562.1.
U00096 Genomic DNA. Translation: AAC75533.1.
AP009048 Genomic DNA. Translation: BAA16358.1.
AF023337 Genomic DNA. Translation: AAC46233.1.
PIRB49749.
RefSeqAP_003066.1.
NP_416975.1.

3D structure databases

ModBaseSearch...

2-D gel databases

SWISS-2DPAGEP0AE52.

Genome annotation databases

GeneID946949.
GenomeReviewsGene locus b2480 in contig U00096_GR.
Gene locus JW2465 in contig AP009048_GR.
KEGGecj:JW2465.
eco:b2480.

Organism-specific databases

EchoBASEEB0106.
EcoGeneEG10108. bcp.
CMRSearch...

Phylogenomic databases

HOGENOMP0AE52.

Enzyme and pathway databases

BioCycEcoCyc:EG10108-MON.
MetaCyc:EG10108-MON.

Family and domain databases

InterProIPR000866. AhpC-TSA.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PfamPF00578. AhpC-TSA. 1 hit.
[Graphical view]
PROSITEPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBCP_ECOLI
AccessionPrimary (citable) accession number: P0AE52
Secondary accession number(s): P23480
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 25, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents