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P0AE52 (BCP_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative peroxiredoxin bcp

EC=1.11.1.15
Alternative name(s):
Bacterioferritin comigratory protein
Thioredoxin reductase
Gene names
Name:bcp
Ordered Locus Names:b2480, JW2465
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length156 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

Sequence similarities

Belongs to the AhpC/TSA family.

Contains 1 thioredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 156156Putative peroxiredoxin bcp
PRO_0000135134

Regions

Domain4 – 156153Thioredoxin

Sites

Active site461Cysteine sulfenic acid (-SOH) intermediate Ref.8

Sequences

Sequence LengthMass (Da)Tools
P0AE52 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: C7D267A671409EFC

FASTA15617,634
        10         20         30         40         50         60 
MNPLKAGDIA PKFSLPDQDG EQVNLTDFQG QRVLVYFYPK AMTPGCTVQA CGLRDNMDEL 

        70         80         90        100        110        120 
KKAGVDVLGI STDKPEKLSR FAEKELLNFT LLSDEDHQVC EQFGVWGEKS FMGKTYDGIH 

       130        140        150 
RISFLIDADG KIEHVFDDFK TSNHHDVVLN WLKEHA 

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References

« Hide 'large scale' references
[1]"A molecular analysis of the 53.3 minute region of the Escherichia coli linkage map."
Andrews S.C., Harrison P.M., Guest J.R.
J. Gen. Microbiol. 137:361-367(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T. expand/collapse author list , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"Promoter characterization and constitutive expression of the Escherichia coli gcvR gene."
Ghrist A.C., Stauffer G.V.
J. Bacteriol. 180:1803-1807(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
Strain: K12.
[6]"Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12."
Link A.J., Robison K., Church G.M.
Electrophoresis 18:1259-1313(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-15.
Strain: K12 / EMG2.
[7]Frutiger S., Hughes G.J., Pasquali C., Hochstrasser D.F.
Submitted (FEB-1996) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 1-11.
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[8]"Thioredoxin-dependent hydroperoxide peroxidase activity of bacterioferritin comigratory protein (BCP) as a new member of the thiol-specific antioxidant protein (TSA)/Alkyl hydroperoxide peroxidase C (AhpC) family."
Jeong W., Cha M.K., Kim I.H.
J. Biol. Chem. 275:2924-2930(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: ACTIVE SITE CYS-46.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M63654 Genomic DNA. Translation: AAB88562.1.
U00096 Genomic DNA. Translation: AAC75533.1.
AP009048 Genomic DNA. Translation: BAA16358.1.
AF023337 Genomic DNA. Translation: AAC46233.1.
PIRB49749.
RefSeqNP_416975.1. NC_000913.2.
YP_490708.1. NC_007779.1.

3D structure databases

ProteinModelPortalP0AE52.
SMRP0AE52. Positions 1-154.
ModBaseSearch...

Protein-protein interaction databases

IntActP0AE52. 6 interactions.
STRING511145.b2480.

2D gel databases

SWISS-2DPAGEP0AE52.

Proteomic databases

PaxDbP0AE52.
PRIDEP0AE52.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC75533; AAC75533; b2480.
BAA16358; BAA16358; BAA16358.
GeneID12931774.
946949.
KEGGecj:Y75_p2433.
eco:b2480.
PATRIC32120347. VBIEscCol129921_2576.

Organism-specific databases

EchoBASEEB0106.
EcoGeneEG10108. bcp.

Phylogenomic databases

eggNOGCOG1225.
HOGENOMHOG000022344.
KOK03564.
OMANHHDIVL.
ProtClustDBPRK09437.

Enzyme and pathway databases

BioCycEcoCyc:EG10108-MONOMER.
ECOL316407:JW2465-MONOMER.
MetaCyc:EG10108-MONOMER.

Gene expression databases

GenevestigatorP0AE52.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000866. AhpC/TSA.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00578. AhpC-TSA. 1 hit.
[Graphical view]
SUPFAMSSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBCP_ECOLI
AccessionPrimary (citable) accession number: P0AE52
Secondary accession number(s): P23480
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families