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Protein

Putative peroxiredoxin bcp

Gene

bcp

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei46 – 461Cysteine sulfenic acid (-SOH) intermediate1 Publication

GO - Molecular functioni

  • hydroperoxide reductase activity Source: EcoCyc
  • thioredoxin peroxidase activity Source: EcoCyc

GO - Biological processi

  • response to oxidative stress Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciEcoCyc:EG10108-MONOMER.
ECOL316407:JW2465-MONOMER.
MetaCyc:EG10108-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative peroxiredoxin bcp (EC:1.11.1.15)
Alternative name(s):
Bacterioferritin comigratory protein
Thioredoxin reductase
Gene namesi
Name:bcp
Ordered Locus Names:b2480, JW2465
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10108. bcp.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Putative peroxiredoxin bcpPRO_0000135134Add
BLAST

Proteomic databases

EPDiP0AE52.
PaxDbiP0AE52.
PRIDEiP0AE52.

2D gel databases

SWISS-2DPAGEP0AE52.

Interactioni

Protein-protein interaction databases

BioGridi4260768. 12 interactions.
851288. 1 interaction.
IntActiP0AE52. 7 interactions.
STRINGi511145.b2480.

Structurei

3D structure databases

ProteinModelPortaliP0AE52.
SMRiP0AE52. Positions 1-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 156153ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the AhpC/TSA family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4108YXY. Bacteria.
COG1225. LUCA.
HOGENOMiHOG000022344.
InParanoidiP0AE52.
KOiK03564.
OMAiCSTQACD.
OrthoDBiEOG6ZH2P1.
PhylomeDBiP0AE52.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AE52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPLKAGDIA PKFSLPDQDG EQVNLTDFQG QRVLVYFYPK AMTPGCTVQA
60 70 80 90 100
CGLRDNMDEL KKAGVDVLGI STDKPEKLSR FAEKELLNFT LLSDEDHQVC
110 120 130 140 150
EQFGVWGEKS FMGKTYDGIH RISFLIDADG KIEHVFDDFK TSNHHDVVLN

WLKEHA
Length:156
Mass (Da):17,634
Last modified:December 6, 2005 - v1
Checksum:iC7D267A671409EFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88562.1.
U00096 Genomic DNA. Translation: AAC75533.1.
AP009048 Genomic DNA. Translation: BAA16358.1.
AF023337 Genomic DNA. Translation: AAC46233.1.
PIRiB49749.
RefSeqiNP_416975.1. NC_000913.3.
WP_001068682.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75533; AAC75533; b2480.
BAA16358; BAA16358; BAA16358.
GeneIDi946949.
KEGGiecj:JW2465.
eco:b2480.
PATRICi32120347. VBIEscCol129921_2576.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88562.1.
U00096 Genomic DNA. Translation: AAC75533.1.
AP009048 Genomic DNA. Translation: BAA16358.1.
AF023337 Genomic DNA. Translation: AAC46233.1.
PIRiB49749.
RefSeqiNP_416975.1. NC_000913.3.
WP_001068682.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AE52.
SMRiP0AE52. Positions 1-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260768. 12 interactions.
851288. 1 interaction.
IntActiP0AE52. 7 interactions.
STRINGi511145.b2480.

2D gel databases

SWISS-2DPAGEP0AE52.

Proteomic databases

EPDiP0AE52.
PaxDbiP0AE52.
PRIDEiP0AE52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75533; AAC75533; b2480.
BAA16358; BAA16358; BAA16358.
GeneIDi946949.
KEGGiecj:JW2465.
eco:b2480.
PATRICi32120347. VBIEscCol129921_2576.

Organism-specific databases

EchoBASEiEB0106.
EcoGeneiEG10108. bcp.

Phylogenomic databases

eggNOGiENOG4108YXY. Bacteria.
COG1225. LUCA.
HOGENOMiHOG000022344.
InParanoidiP0AE52.
KOiK03564.
OMAiCSTQACD.
OrthoDBiEOG6ZH2P1.
PhylomeDBiP0AE52.

Enzyme and pathway databases

BioCyciEcoCyc:EG10108-MONOMER.
ECOL316407:JW2465-MONOMER.
MetaCyc:EG10108-MONOMER.

Miscellaneous databases

PROiP0AE52.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A molecular analysis of the 53.3 minute region of the Escherichia coli linkage map."
    Andrews S.C., Harrison P.M., Guest J.R.
    J. Gen. Microbiol. 137:361-367(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Promoter characterization and constitutive expression of the Escherichia coli gcvR gene."
    Ghrist A.C., Stauffer G.V.
    J. Bacteriol. 180:1803-1807(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-32.
    Strain: K12.
  6. "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12."
    Link A.J., Robison K., Church G.M.
    Electrophoresis 18:1259-1313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-15.
    Strain: K12 / EMG2.
  7. Frutiger S., Hughes G.J., Pasquali C., Hochstrasser D.F.
    Submitted (FEB-1996) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-11.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  8. "Thioredoxin-dependent hydroperoxide peroxidase activity of bacterioferritin comigratory protein (BCP) as a new member of the thiol-specific antioxidant protein (TSA)/Alkyl hydroperoxide peroxidase C (AhpC) family."
    Jeong W., Cha M.K., Kim I.H.
    J. Biol. Chem. 275:2924-2930(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACTIVE SITE CYS-46.

Entry informationi

Entry nameiBCP_ECOLI
AccessioniPrimary (citable) accession number: P0AE52
Secondary accession number(s): P23480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: July 6, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.