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Protein

Gamma-glutamylcyclotransferase family protein YtfP

Gene

ytfP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in antibiotic biosynthesis.Curated

Enzyme and pathway databases

BioCyciEcoCyc:G7876-MONOMER.
ECOL316407:JW4181-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamylcyclotransferase family protein YtfP
Gene namesi
Name:ytfP
Ordered Locus Names:b4222, JW4181
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12516. ytfP.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001847891 – 113Gamma-glutamylcyclotransferase family protein YtfPAdd BLAST113

Proteomic databases

PaxDbiP0AE48.
PRIDEiP0AE48.

Interactioni

Protein-protein interaction databases

BioGridi4260673. 12 interactors.
IntActiP0AE48. 1 interactor.
STRINGi511145.b4222.

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 5Combined sources4
Turni14 – 16Combined sources3
Helixi17 – 20Combined sources4
Beta strandi23 – 37Combined sources15
Beta strandi39 – 49Combined sources11
Beta strandi51 – 57Combined sources7
Helixi60 – 70Combined sources11
Beta strandi76 – 83Combined sources8
Beta strandi86 – 93Combined sources8
Beta strandi101 – 105Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XHSNMR-A1-113[»]
ProteinModelPortaliP0AE48.
SMRiP0AE48.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AE48.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108ZHD. Bacteria.
COG2105. LUCA.
HOGENOMiHOG000261862.
InParanoidiP0AE48.
OMAiYRINSTI.
PhylomeDBiP0AE48.

Family and domain databases

CDDicd06661. GGCT_like. 1 hit.
Gene3Di3.10.490.10. 1 hit.
InterProiIPR009288. AIG2-like.
IPR013024. GGCT-like.
[Graphical view]
PfamiPF06094. GGACT. 1 hit.
[Graphical view]
SUPFAMiSSF110857. SSF110857. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AE48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIFVYGSLR HKQGNSHWMT NAQLLGDFSI DNYQLYSLGH YPGAVPGNGT
60 70 80 90 100
VHGEVYRIDN ATLAELDALR TRGGEYARQL IQTPYGSAWM YVYQRPVDGL
110
KLIESGDWLD RDK
Length:113
Mass (Da):12,866
Last modified:December 6, 2005 - v1
Checksum:iA320C9DC94607CF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97119.1.
U00096 Genomic DNA. Translation: AAC77179.1.
AP009048 Genomic DNA. Translation: BAE78223.1.
PIRiS56448.
RefSeqiNP_418643.1. NC_000913.3.
WP_001219160.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77179; AAC77179; b4222.
BAE78223; BAE78223; BAE78223.
GeneIDi948741.
KEGGiecj:JW4181.
eco:b4222.
PATRICi32124021. VBIEscCol129921_4355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97119.1.
U00096 Genomic DNA. Translation: AAC77179.1.
AP009048 Genomic DNA. Translation: BAE78223.1.
PIRiS56448.
RefSeqiNP_418643.1. NC_000913.3.
WP_001219160.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XHSNMR-A1-113[»]
ProteinModelPortaliP0AE48.
SMRiP0AE48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260673. 12 interactors.
IntActiP0AE48. 1 interactor.
STRINGi511145.b4222.

Proteomic databases

PaxDbiP0AE48.
PRIDEiP0AE48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77179; AAC77179; b4222.
BAE78223; BAE78223; BAE78223.
GeneIDi948741.
KEGGiecj:JW4181.
eco:b4222.
PATRICi32124021. VBIEscCol129921_4355.

Organism-specific databases

EchoBASEiEB2408.
EcoGeneiEG12516. ytfP.

Phylogenomic databases

eggNOGiENOG4108ZHD. Bacteria.
COG2105. LUCA.
HOGENOMiHOG000261862.
InParanoidiP0AE48.
OMAiYRINSTI.
PhylomeDBiP0AE48.

Enzyme and pathway databases

BioCyciEcoCyc:G7876-MONOMER.
ECOL316407:JW4181-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0AE48.
PROiP0AE48.

Family and domain databases

CDDicd06661. GGCT_like. 1 hit.
Gene3Di3.10.490.10. 1 hit.
InterProiIPR009288. AIG2-like.
IPR013024. GGCT-like.
[Graphical view]
PfamiPF06094. GGACT. 1 hit.
[Graphical view]
SUPFAMiSSF110857. SSF110857. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYTFP_ECOLI
AccessioniPrimary (citable) accession number: P0AE48
Secondary accession number(s): P39323, Q2M683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Lacks the conserved Glu residue at position 70 that serves as proton acceptor in enzymes with gamma-glutamylcyclotransferase activity.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.