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Protein

Gamma-glutamylcyclotransferase family protein YtfP

Gene

ytfP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in antibiotic biosynthesis.Curated

Enzyme and pathway databases

BioCyciEcoCyc:G7876-MONOMER.
ECOL316407:JW4181-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamylcyclotransferase family protein YtfP
Gene namesi
Name:ytfP
Ordered Locus Names:b4222, JW4181
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12516. ytfP.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 113113Gamma-glutamylcyclotransferase family protein YtfPPRO_0000184789Add
BLAST

Proteomic databases

EPDiP0AE48.
PaxDbiP0AE48.
PRIDEiP0AE48.

Interactioni

Protein-protein interaction databases

BioGridi4260673. 12 interactions.
IntActiP0AE48. 1 interaction.
STRINGi511145.b4222.

Structurei

Secondary structure

1
113
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 54Combined sources
Turni14 – 163Combined sources
Helixi17 – 204Combined sources
Beta strandi23 – 3715Combined sources
Beta strandi39 – 4911Combined sources
Beta strandi51 – 577Combined sources
Helixi60 – 7011Combined sources
Beta strandi76 – 838Combined sources
Beta strandi86 – 938Combined sources
Beta strandi101 – 1055Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XHSNMR-A1-113[»]
ProteinModelPortaliP0AE48.
SMRiP0AE48. Positions 1-113.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AE48.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108ZHD. Bacteria.
COG2105. LUCA.
HOGENOMiHOG000261862.
InParanoidiP0AE48.
OMAiYRINSTI.
OrthoDBiEOG6Z9B7M.
PhylomeDBiP0AE48.

Family and domain databases

Gene3Di3.10.490.10. 1 hit.
InterProiIPR009288. AIG2-like.
IPR013024. Butirosin_synth_BtrG-like.
[Graphical view]
PfamiPF06094. GGACT. 1 hit.
[Graphical view]
SUPFAMiSSF110857. SSF110857. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AE48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIFVYGSLR HKQGNSHWMT NAQLLGDFSI DNYQLYSLGH YPGAVPGNGT
60 70 80 90 100
VHGEVYRIDN ATLAELDALR TRGGEYARQL IQTPYGSAWM YVYQRPVDGL
110
KLIESGDWLD RDK
Length:113
Mass (Da):12,866
Last modified:December 6, 2005 - v1
Checksum:iA320C9DC94607CF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97119.1.
U00096 Genomic DNA. Translation: AAC77179.1.
AP009048 Genomic DNA. Translation: BAE78223.1.
PIRiS56448.
RefSeqiNP_418643.1. NC_000913.3.
WP_001219160.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77179; AAC77179; b4222.
BAE78223; BAE78223; BAE78223.
GeneIDi948741.
KEGGiecj:JW4181.
eco:b4222.
PATRICi32124021. VBIEscCol129921_4355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97119.1.
U00096 Genomic DNA. Translation: AAC77179.1.
AP009048 Genomic DNA. Translation: BAE78223.1.
PIRiS56448.
RefSeqiNP_418643.1. NC_000913.3.
WP_001219160.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XHSNMR-A1-113[»]
ProteinModelPortaliP0AE48.
SMRiP0AE48. Positions 1-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260673. 12 interactions.
IntActiP0AE48. 1 interaction.
STRINGi511145.b4222.

Proteomic databases

EPDiP0AE48.
PaxDbiP0AE48.
PRIDEiP0AE48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77179; AAC77179; b4222.
BAE78223; BAE78223; BAE78223.
GeneIDi948741.
KEGGiecj:JW4181.
eco:b4222.
PATRICi32124021. VBIEscCol129921_4355.

Organism-specific databases

EchoBASEiEB2408.
EcoGeneiEG12516. ytfP.

Phylogenomic databases

eggNOGiENOG4108ZHD. Bacteria.
COG2105. LUCA.
HOGENOMiHOG000261862.
InParanoidiP0AE48.
OMAiYRINSTI.
OrthoDBiEOG6Z9B7M.
PhylomeDBiP0AE48.

Enzyme and pathway databases

BioCyciEcoCyc:G7876-MONOMER.
ECOL316407:JW4181-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0AE48.
PROiP0AE48.

Family and domain databases

Gene3Di3.10.490.10. 1 hit.
InterProiIPR009288. AIG2-like.
IPR013024. Butirosin_synth_BtrG-like.
[Graphical view]
PfamiPF06094. GGACT. 1 hit.
[Graphical view]
SUPFAMiSSF110857. SSF110857. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
    Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Solution NMR structure of Escherichia coli YtfP expands the structural coverage of the UPF0131 protein domain family."
    Aramini J.M., Huang Y.J., Swapna G.V., Cort J.R., Rajan P.K., Xiao R., Shastry R., Acton T.B., Liu J., Rost B., Kennedy M.A., Montelione G.T.
    Proteins 68:789-795(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, PROPOSED FUNCTION.

Entry informationi

Entry nameiYTFP_ECOLI
AccessioniPrimary (citable) accession number: P0AE48
Secondary accession number(s): P39323, Q2M683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: March 16, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Lacks the conserved Glu residue at position 70 that serves as proton acceptor in enzymes with gamma-glutamylcyclotransferase activity.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.