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Protein

UPF0053 inner membrane protein YtfL

Gene

ytfL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7873-MONOMER.
ECOL316407:JW4177-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0053 inner membrane protein YtfL
Gene namesi
Name:ytfL
Ordered Locus Names:b4218, JW4177
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12512. ytfL.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4PeriplasmicSequence analysis4
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 55CytoplasmicSequence analysisAdd BLAST30
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 99PeriplasmicSequence analysisAdd BLAST23
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 141CytoplasmicSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 308PeriplasmicSequence analysisAdd BLAST146
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Topological domaini330 – 447CytoplasmicSequence analysisAdd BLAST118

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000883621 – 447UPF0053 inner membrane protein YtfLAdd BLAST447

Proteomic databases

PaxDbiP0AE45.
PRIDEiP0AE45.

Interactioni

Protein-protein interaction databases

DIPiDIP-48233N.
STRINGi511145.b4218.

Structurei

3D structure databases

ProteinModelPortaliP0AE45.
SMRiP0AE45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 197DUF21Add BLAST193
Domaini216 – 275CBS 1PROSITE-ProRule annotationAdd BLAST60
Domaini282 – 343CBS 2PROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Belongs to the UPF0053 family.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation
Contains 1 DUF21 domain.Curated

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C37. Bacteria.
COG1253. LUCA.
HOGENOMiHOG000062295.
InParanoidiP0AE45.
OMAiQPHSKFL.
PhylomeDBiP0AE45.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR002550. DUF21.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF03471. CorC_HlyC. 1 hit.
PF01595. DUF21. 1 hit.
[Graphical view]
SMARTiSM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AE45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNSILVILC LIAVSAFFSM SEISLAASRK IKLKLLADEG NINAQRVLNM
60 70 80 90 100
QENPGMFFTV VQIGLNAVAI LGGIVGDAAF SPAFHSLFSR YMSAELSEQL
110 120 130 140 150
SFILSFSLVT GMFILFADLT PKRIGMIAPE AVALRIINPM RFCLYVCTPL
160 170 180 190 200
VWFFNGLANI IFRIFKLPMV RKDDITSDDI YAVVEAGALA GVLRKQEHEL
210 220 230 240 250
IENVFELESR TVPSSMTPRE NVIWFDLHED EQSLKNKVAE HPHSKFLVCN
260 270 280 290 300
EDIDHIIGYV DSKDLLNRVL ANQSLALNSG VQIRNTLIVP DTLTLSEALE
310 320 330 340 350
SFKTAGEDFA VIMNEYALVV GIITLNDVMT TLMGDLVGQG LEEQIVARDE
360 370 380 390 400
NSWLIDGGTP IDDVMRVLDI DEFPQSGNYE TIGGFMMFML RKIPKRTDSV
410 420 430 440
KFAGYKFEVV DIDNYRIDQL LVTRIDSKAT ALSPKLPDAK DKEESVA
Length:447
Mass (Da):49,763
Last modified:December 6, 2005 - v1
Checksum:i22C0DB3FAE5D926F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97114.1.
U00096 Genomic DNA. Translation: AAC77175.1.
AP009048 Genomic DNA. Translation: BAE78219.1.
PIRiS56443.
RefSeqiNP_418639.1. NC_000913.3.
WP_000935036.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77175; AAC77175; b4218.
BAE78219; BAE78219; BAE78219.
GeneIDi948735.
KEGGiecj:JW4177.
eco:b4218.
PATRICi32124011. VBIEscCol129921_4350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA. Translation: AAA97114.1.
U00096 Genomic DNA. Translation: AAC77175.1.
AP009048 Genomic DNA. Translation: BAE78219.1.
PIRiS56443.
RefSeqiNP_418639.1. NC_000913.3.
WP_000935036.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AE45.
SMRiP0AE45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48233N.
STRINGi511145.b4218.

Proteomic databases

PaxDbiP0AE45.
PRIDEiP0AE45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77175; AAC77175; b4218.
BAE78219; BAE78219; BAE78219.
GeneIDi948735.
KEGGiecj:JW4177.
eco:b4218.
PATRICi32124011. VBIEscCol129921_4350.

Organism-specific databases

EchoBASEiEB2405.
EcoGeneiEG12512. ytfL.

Phylogenomic databases

eggNOGiENOG4105C37. Bacteria.
COG1253. LUCA.
HOGENOMiHOG000062295.
InParanoidiP0AE45.
OMAiQPHSKFL.
PhylomeDBiP0AE45.

Enzyme and pathway databases

BioCyciEcoCyc:G7873-MONOMER.
ECOL316407:JW4177-MONOMER.

Miscellaneous databases

PROiP0AE45.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR002550. DUF21.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF03471. CorC_HlyC. 1 hit.
PF01595. DUF21. 1 hit.
[Graphical view]
SMARTiSM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYTFL_ECOLI
AccessioniPrimary (citable) accession number: P0AE45
Secondary accession number(s): P39319, Q2M687
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.