Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UPF0053 inner membrane protein YtfL

Gene

ytfL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

BioCyciEcoCyc:G7873-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0053 inner membrane protein YtfL
Gene namesi
Name:ytfL
Ordered Locus Names:b4218, JW4177
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12512 ytfL

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4PeriplasmicSequence analysis4
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 55CytoplasmicSequence analysisAdd BLAST30
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 99PeriplasmicSequence analysisAdd BLAST23
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 141CytoplasmicSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 308PeriplasmicSequence analysisAdd BLAST146
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Topological domaini330 – 447CytoplasmicSequence analysisAdd BLAST118

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000883621 – 447UPF0053 inner membrane protein YtfLAdd BLAST447

Proteomic databases

PaxDbiP0AE45
PRIDEiP0AE45

Interactioni

Protein-protein interaction databases

BioGridi4259306, 58 interactors
DIPiDIP-48233N
IntActiP0AE45, 3 interactors
STRINGi316385.ECDH10B_4413

Structurei

3D structure databases

ProteinModelPortaliP0AE45
SMRiP0AE45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 197CNNM transmembranePROSITE-ProRule annotationAdd BLAST197
Domaini216 – 275CBS 1PROSITE-ProRule annotationAdd BLAST60
Domaini282 – 343CBS 2PROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Belongs to the UPF0053 family.Curated

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C37 Bacteria
COG1253 LUCA
HOGENOMiHOG000062295
InParanoidiP0AE45
OMAiYLTMEDV
PhylomeDBiP0AE45

Family and domain databases

InterProiView protein in InterPro
IPR000644 CBS_dom
IPR002550 DUF21
IPR036318 FAD-bd_2-like_sf
IPR005170 Transptr-assoc_dom
PfamiView protein in Pfam
PF00571 CBS, 1 hit
PF03471 CorC_HlyC, 1 hit
PF01595 DUF21, 1 hit
SMARTiView protein in SMART
SM01091 CorC_HlyC, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits
PS51846 CNNM, 1 hit

Sequencei

Sequence statusi: Complete.

P0AE45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNSILVILC LIAVSAFFSM SEISLAASRK IKLKLLADEG NINAQRVLNM
60 70 80 90 100
QENPGMFFTV VQIGLNAVAI LGGIVGDAAF SPAFHSLFSR YMSAELSEQL
110 120 130 140 150
SFILSFSLVT GMFILFADLT PKRIGMIAPE AVALRIINPM RFCLYVCTPL
160 170 180 190 200
VWFFNGLANI IFRIFKLPMV RKDDITSDDI YAVVEAGALA GVLRKQEHEL
210 220 230 240 250
IENVFELESR TVPSSMTPRE NVIWFDLHED EQSLKNKVAE HPHSKFLVCN
260 270 280 290 300
EDIDHIIGYV DSKDLLNRVL ANQSLALNSG VQIRNTLIVP DTLTLSEALE
310 320 330 340 350
SFKTAGEDFA VIMNEYALVV GIITLNDVMT TLMGDLVGQG LEEQIVARDE
360 370 380 390 400
NSWLIDGGTP IDDVMRVLDI DEFPQSGNYE TIGGFMMFML RKIPKRTDSV
410 420 430 440
KFAGYKFEVV DIDNYRIDQL LVTRIDSKAT ALSPKLPDAK DKEESVA
Length:447
Mass (Da):49,763
Last modified:December 6, 2005 - v1
Checksum:i22C0DB3FAE5D926F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97114.1
U00096 Genomic DNA Translation: AAC77175.1
AP009048 Genomic DNA Translation: BAE78219.1
PIRiS56443
RefSeqiNP_418639.1, NC_000913.3
WP_000935036.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77175; AAC77175; b4218
BAE78219; BAE78219; BAE78219
GeneIDi948735
KEGGiecj:JW4177
eco:b4218
PATRICifig|1411691.4.peg.2483

Similar proteinsi

Entry informationi

Entry nameiYTFL_ECOLI
AccessioniPrimary (citable) accession number: P0AE45
Secondary accession number(s): P39319, Q2M687
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health