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Protein

Transcriptional regulatory protein YpdB

Gene

ypdB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system YpdA/YpdB involved in carbon control network. Regulates expression of yhjX by binding to its promoter region.1 Publication

GO - Molecular functioni

  • DNA binding Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7244-MONOMER.
ECOL316407:JW2378-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein YpdB
Gene namesi
Name:ypdB
Ordered Locus Names:b2381, JW2378
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14149. ypdB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi53 – 531D → E: Strong induction of yhjX. 1 Publication
Mutagenesisi53 – 531D → N: Prevents yhjX induction. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Transcriptional regulatory protein YpdBPRO_0000081381Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 5314-aspartylphosphateCurated

Post-translational modificationi

Phosphorylated by YpdA.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0AE39.
PRIDEiP0AE39.

Interactioni

Protein-protein interaction databases

BioGridi4260560. 22 interactions.
DIPiDIP-48228N.
IntActiP0AE39. 1 interaction.
STRINGi511145.b2381.

Structurei

3D structure databases

ProteinModelPortaliP0AE39.
SMRiP0AE39. Positions 1-122, 148-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 116115Response regulatoryPROSITE-ProRule annotationAdd
BLAST
Domaini139 – 244106HTH LytTR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH LytTR-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105DY9. Bacteria.
COG3279. LUCA.
HOGENOMiHOG000242207.
InParanoidiP0AE39.
KOiK02477.
OMAiSYLIRVP.
PhylomeDBiP0AE39.

Family and domain databases

InterProiIPR011006. CheY-like_superfamily.
IPR007492. LytTR_DNA-bd_dom.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF04397. LytTR. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00850. LytTR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50930. HTH_LYTTR. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AE39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVIIVEDEF LAQQELSWLI KEHSQMEIVG TFDDGLDVLK FLQHNRVDAI
60 70 80 90 100
FLDINIPSLD GVLLAQNISQ FAHKPFIVFI TAWKEHAVEA FELEAFDYIL
110 120 130 140 150
KPYQESRITG MLQKLEAAWQ QQQTSSTPAA TVTRENDTIN LVKDERIIVT
160 170 180 190 200
PINDIYYAEA HEKMTFVYTR RESYVMPMNI TEFCSKLPPS HFFRCHRSFC
210 220 230 240
VNLNKIREIE PWFNNTYILR LKDLDFEVPV SRSKVKEFRQ LMHL
Length:244
Mass (Da):28,721
Last modified:December 6, 2005 - v1
Checksum:i679EA97A44F1260B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75440.1.
AP009048 Genomic DNA. Translation: BAA16251.1.
PIRiB65012.
RefSeqiNP_416882.1. NC_000913.3.
WP_001295458.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75440; AAC75440; b2381.
BAA16251; BAA16251; BAA16251.
GeneIDi947395.
KEGGiecj:JW2378.
eco:b2381.
PATRICi32120141. VBIEscCol129921_2479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75440.1.
AP009048 Genomic DNA. Translation: BAA16251.1.
PIRiB65012.
RefSeqiNP_416882.1. NC_000913.3.
WP_001295458.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AE39.
SMRiP0AE39. Positions 1-122, 148-242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260560. 22 interactions.
DIPiDIP-48228N.
IntActiP0AE39. 1 interaction.
STRINGi511145.b2381.

Proteomic databases

PaxDbiP0AE39.
PRIDEiP0AE39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75440; AAC75440; b2381.
BAA16251; BAA16251; BAA16251.
GeneIDi947395.
KEGGiecj:JW2378.
eco:b2381.
PATRICi32120141. VBIEscCol129921_2479.

Organism-specific databases

EchoBASEiEB3901.
EcoGeneiEG14149. ypdB.

Phylogenomic databases

eggNOGiENOG4105DY9. Bacteria.
COG3279. LUCA.
HOGENOMiHOG000242207.
InParanoidiP0AE39.
KOiK02477.
OMAiSYLIRVP.
PhylomeDBiP0AE39.

Enzyme and pathway databases

BioCyciEcoCyc:G7244-MONOMER.
ECOL316407:JW2378-MONOMER.

Miscellaneous databases

PROiP0AE39.

Family and domain databases

InterProiIPR011006. CheY-like_superfamily.
IPR007492. LytTR_DNA-bd_dom.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF04397. LytTR. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00850. LytTR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50930. HTH_LYTTR. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYPDB_ECOLI
AccessioniPrimary (citable) accession number: P0AE39
Secondary accession number(s): P77742
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.