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Protein

Transcriptional regulatory protein YpdB

Gene

ypdB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system YpdA/YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA/YpdB, the high-affinity pyruvate signaling system BtsS/BtsR and their respective target proteins, YhjX and YjiY. YpdB regulates expression of yhjX by binding to its promoter region. Activation of the YpdA/YpdB signaling cascade also promotes BtsS/BtsR-mediated yjiY expression.2 Publications

GO - Molecular functioni

  • DNA binding Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Enzyme and pathway databases

BioCyciEcoCyc:G7244-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein YpdBCurated
Gene namesi
Name:ypdB
Ordered Locus Names:b2381, JW2378
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14149. ypdB.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi53D → E: Strong induction of yhjX. 1 Publication1
Mutagenesisi53D → N: Prevents yhjX induction. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000813811 – 244Transcriptional regulatory protein YpdBAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by YpdA.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0AE39.
PRIDEiP0AE39.

Interactioni

Protein-protein interaction databases

BioGridi4260560. 22 interactors.
DIPiDIP-48228N.
IntActiP0AE39. 1 interactor.
STRINGi316385.ECDH10B_2546.

Structurei

3D structure databases

ProteinModelPortaliP0AE39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 116Response regulatoryPROSITE-ProRule annotationAdd BLAST115
Domaini139 – 244HTH LytTR-typePROSITE-ProRule annotationAdd BLAST106

Phylogenomic databases

eggNOGiENOG4105DY9. Bacteria.
COG3279. LUCA.
HOGENOMiHOG000242207.
InParanoidiP0AE39.
KOiK02477.
PhylomeDBiP0AE39.

Family and domain databases

CDDicd00156. REC. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR007492. LytTR_DNA-bd_dom.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF04397. LytTR. 1 hit.
PF00072. Response_reg. 1 hit.
SMARTiView protein in SMART
SM00850. LytTR. 1 hit.
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiView protein in PROSITE
PS50930. HTH_LYTTR. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AE39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVIIVEDEF LAQQELSWLI KEHSQMEIVG TFDDGLDVLK FLQHNRVDAI
60 70 80 90 100
FLDINIPSLD GVLLAQNISQ FAHKPFIVFI TAWKEHAVEA FELEAFDYIL
110 120 130 140 150
KPYQESRITG MLQKLEAAWQ QQQTSSTPAA TVTRENDTIN LVKDERIIVT
160 170 180 190 200
PINDIYYAEA HEKMTFVYTR RESYVMPMNI TEFCSKLPPS HFFRCHRSFC
210 220 230 240
VNLNKIREIE PWFNNTYILR LKDLDFEVPV SRSKVKEFRQ LMHL
Length:244
Mass (Da):28,721
Last modified:December 6, 2005 - v1
Checksum:i679EA97A44F1260B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75440.1.
AP009048 Genomic DNA. Translation: BAA16251.1.
PIRiB65012.
RefSeqiNP_416882.1. NC_000913.3.
WP_001295458.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75440; AAC75440; b2381.
BAA16251; BAA16251; BAA16251.
GeneIDi947395.
KEGGiecj:JW2378.
eco:b2381.
PATRICifig|1411691.4.peg.4347.

Similar proteinsi

Entry informationi

Entry nameiYPDB_ECOLI
AccessioniPrimary (citable) accession number: P0AE39
Secondary accession number(s): P77742
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: August 30, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene