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P0AE38 (ASTA_ECO57) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Arginine N-succinyltransferase

Short name=AST
EC=2.3.1.109
Alternative name(s):
AOST
Gene names
Name:astA
Ordered Locus Names:Z2779, ECs2453
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine By similarity. HAMAP MF_01171

Catalytic activity

Succinyl-CoA + L-arginine = CoA + N(2)-succinyl-L-arginine. HAMAP MF_01171

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 1/5. HAMAP MF_01171

Sequence similarities

Belongs to the arginine N-succinyltransferase family.

Ontologies

Keywords
   Biological processArginine metabolism
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionarginine N-succinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Arginine N-succinyltransferase HAMAP MF_01171
PRO_0000064713

Sites

Active site2291Proton donor Potential
Binding site1251Succinyl-CoA; via amide nitrogen Potential

Sequences

Sequence LengthMass (Da)Tools
P0AE38 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 89C7BB412A880BEF

FASTA34438,456
        10         20         30         40         50         60 
MMVIRPVERS DVSALMQLAS KTGGGLTSLP ANEATLSARI ERAIKTWQGE LPKSEQGYVF 

        70         80         90        100        110        120 
VLEDSETGTV AGICAIEVAV GLNDPWYNYR VGTLVHASKE LNVYNALPTL FLSNDHTGSS 

       130        140        150        160        170        180 
ELCTLFLDPD WRKEGNGYLL SKSRFMFMAA FRDKFNDKVV AEMRGVIDEH GYSPFWQSLG 

       190        200        210        220        230        240 
KRFFSMDFSR ADFLCGTGQK AFIAELMPKH PIYTHFLSQE AQDVIGQVHP QTAPARAVLE 

       250        260        270        280        290        300 
KEGFRYRNYI DIFDGGPTLE CDIDRVRAIR KSRLVEVAEG QPAQGDFPAC LVANENYHHF 

       310        320        330        340 
RVVLVRTDPA TERLILTAAQ LDALKCHAGD RVRLVRLCAE EKTA 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005174 Genomic DNA. Translation: AAG56733.1.
BA000007 Genomic DNA. Translation: BAB35876.1.
PIRA85784.
E90935.
RefSeqNP_288180.1. NC_002655.2.
NP_310480.1. NC_002695.1.

3D structure databases

ProteinModelPortalP0AE38.
SMRP0AE38. Positions 1-339.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000024593; EBESCP00000023486; EBESCG00000023647.
EBESCT00000059935; EBESCP00000057763; EBESCG00000058982.
GeneID913079.
961718.
GenomeReviewsGene locus Z2779 in contig AE005174_GR.
Gene locus ECs2453 in contig BA000007_GR.
KEGGece:Z2779.
ecs:ECs2453.
PATRIC18354250. VBIEscCol44059_2336.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000009322.
HOGENOMHBG377601.
OMAAGPAIEC.
ProtClustDBPRK10456.

Enzyme and pathway databases

BioCycECOL83334:ECS2453-MONOMER.

Family and domain databases

HAMAPMF_01171. AstA.
[Tree]
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR007041. Arg_N-succinylTrfase_Ast/AOST.
IPR017650. Arginine_N-succinylTrfase_AstA.
[Graphical view]
Gene3DG3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 2 hits.
KOK00673.
PfamPF04958. AstA. 1 hit.
[Graphical view]
SUPFAMSSF55729. Acyl_CoA_acyltransferase. 1 hit.
TIGRFAMsTIGR03243. Arg_catab_AOST. 1 hit.
TIGR03244. Arg_catab_AstA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASTA_ECO57
AccessionPrimary (citable) accession number: P0AE38
Secondary accession number(s): P76218
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families