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P0AE37

- ASTA_ECOLI

UniProt

P0AE37 - ASTA_ECOLI

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Protein

Arginine N-succinyltransferase

Gene

astA

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine.1 Publication

Catalytic activityi

Succinyl-CoA + L-arginine = CoA + N(2)-succinyl-L-arginine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei125 – 1251Succinyl-CoA; via amide nitrogenSequence Analysis
Active sitei229 – 2291Proton donorSequence Analysis

GO - Molecular functioni

  1. arginine N-succinyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine catabolic process to glutamate Source: UniProtKB-HAMAP
  2. arginine catabolic process to succinate Source: UniProtKB-UniPathway
  3. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Arginine metabolism, Stress response

Enzyme and pathway databases

BioCyciEcoCyc:ARGSUCCTRAN-MONOMER.
ECOL316407:JW1736-MONOMER.
MetaCyc:ARGSUCCTRAN-MONOMER.
UniPathwayiUPA00185; UER00279.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine N-succinyltransferase (EC:2.3.1.109)
Short name:
AST
Alternative name(s):
AOST
Gene namesi
Name:astA
Synonyms:ydjV
Ordered Locus Names:b1747, JW1736
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13998. astA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Arginine N-succinyltransferasePRO_0000064712Add
BLAST

Proteomic databases

PRIDEiP0AE37.

Expressioni

Inductioni

By nitrogen starvation, and arginine. Induced at stationary phase by sigma S.1 Publication

Gene expression databases

GenevestigatoriP0AE37.

Interactioni

Protein-protein interaction databases

IntActiP0AE37. 6 interactions.
STRINGi511145.b1747.

Structurei

3D structure databases

ProteinModelPortaliP0AE37.
SMRiP0AE37. Positions 1-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3138.
HOGENOMiHOG000258231.
InParanoidiP0AE37.
KOiK00673.
OMAiRFFSMEF.
OrthoDBiEOG6XQ3H4.
PhylomeDBiP0AE37.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01171. AstA.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR007041. Arg_N-succinylTrfase_Ast/AOST.
IPR017650. Arginine_N-succinylTrfase_AstA.
[Graphical view]
PfamiPF04958. AstA. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03243. arg_catab_AOST. 1 hit.
TIGR03244. arg_catab_AstA. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AE37-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMVIRPVERS DVSALMQLAS KTGGGLTSLP ANEATLSARI ERAIKTWQGE
60 70 80 90 100
LPKSEQGYVF VLEDSETGTV AGICAIEVAV GLNDPWYNYR VGTLVHASKE
110 120 130 140 150
LNVYNALPTL FLSNDHTGSS ELCTLFLDPD WRKEGNGYLL SKSRFMFMAA
160 170 180 190 200
FRDKFNDKVV AEMRGVIDEH GYSPFWQSLG KRFFSMDFSR ADFLCGTGQK
210 220 230 240 250
AFIAELMPKH PIYTHFLSQE AQDVIGQVHP QTAPARAVLE KEGFRYRNYI
260 270 280 290 300
DIFDGGPTLE CDIDRVRAIR KSRLVEVAEG QPAQGDFPAC LVANENYHHF
310 320 330 340
RVVLVRTDPA TERLILTAAQ LDALKCHAGD RVRLVRLCAE EKTA
Length:344
Mass (Da):38,456
Last modified:December 6, 2005 - v1
Checksum:i89C7BB412A880BEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74817.1.
AP009048 Genomic DNA. Translation: BAE76517.1.
PIRiC64934.
RefSeqiNP_416261.1. NC_000913.3.
YP_490008.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74817; AAC74817; b1747.
BAE76517; BAE76517; BAE76517.
GeneIDi12933241.
946261.
KEGGiecj:Y75_p1722.
eco:b1747.
PATRICi32118803. VBIEscCol129921_1819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74817.1 .
AP009048 Genomic DNA. Translation: BAE76517.1 .
PIRi C64934.
RefSeqi NP_416261.1. NC_000913.3.
YP_490008.1. NC_007779.1.

3D structure databases

ProteinModelPortali P0AE37.
SMRi P0AE37. Positions 1-335.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P0AE37. 6 interactions.
STRINGi 511145.b1747.

Proteomic databases

PRIDEi P0AE37.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74817 ; AAC74817 ; b1747 .
BAE76517 ; BAE76517 ; BAE76517 .
GeneIDi 12933241.
946261.
KEGGi ecj:Y75_p1722.
eco:b1747.
PATRICi 32118803. VBIEscCol129921_1819.

Organism-specific databases

EchoBASEi EB3754.
EcoGenei EG13998. astA.

Phylogenomic databases

eggNOGi COG3138.
HOGENOMi HOG000258231.
InParanoidi P0AE37.
KOi K00673.
OMAi RFFSMEF.
OrthoDBi EOG6XQ3H4.
PhylomeDBi P0AE37.

Enzyme and pathway databases

UniPathwayi UPA00185 ; UER00279 .
BioCyci EcoCyc:ARGSUCCTRAN-MONOMER.
ECOL316407:JW1736-MONOMER.
MetaCyc:ARGSUCCTRAN-MONOMER.

Miscellaneous databases

PROi P0AE37.

Gene expression databases

Genevestigatori P0AE37.

Family and domain databases

Gene3Di 3.40.630.30. 2 hits.
HAMAPi MF_01171. AstA.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR007041. Arg_N-succinylTrfase_Ast/AOST.
IPR017650. Arginine_N-succinylTrfase_AstA.
[Graphical view ]
Pfami PF04958. AstA. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
TIGRFAMsi TIGR03243. arg_catab_AOST. 1 hit.
TIGR03244. arg_catab_AstA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli."
    Schneider B.L., Kiupakis A.K., Reitzer L.J.
    J. Bacteriol. 180:4278-4286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "ArgR-independent induction and ArgR-dependent superinduction of the astCADBE operon in Escherichia coli."
    Kiupakis A.K., Reitzer L.
    J. Bacteriol. 184:2940-2950(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "Prediction of the structure and function of AstA and AstB, the first two enzymes of the arginine succinyltransferase pathway of arginine catabolism."
    Shirai H., Mizuguchi K.
    FEBS Lett. 555:505-510(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING, REACTION MECHANISM.

Entry informationi

Entry nameiASTA_ECOLI
AccessioniPrimary (citable) accession number: P0AE37
Secondary accession number(s): P76218, Q2MB39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3