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P0AE37

- ASTA_ECOLI

UniProt

P0AE37 - ASTA_ECOLI

Protein

Arginine N-succinyltransferase

Gene

astA

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine.1 Publication

    Catalytic activityi

    Succinyl-CoA + L-arginine = CoA + N(2)-succinyl-L-arginine.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei125 – 1251Succinyl-CoA; via amide nitrogenSequence Analysis
    Active sitei229 – 2291Proton donorSequence Analysis

    GO - Molecular functioni

    1. arginine N-succinyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine catabolic process to glutamate Source: UniProtKB-HAMAP
    2. arginine catabolic process to succinate Source: UniProtKB-UniPathway
    3. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Arginine metabolism, Stress response

    Enzyme and pathway databases

    BioCyciEcoCyc:ARGSUCCTRAN-MONOMER.
    ECOL316407:JW1736-MONOMER.
    MetaCyc:ARGSUCCTRAN-MONOMER.
    UniPathwayiUPA00185; UER00279.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine N-succinyltransferase (EC:2.3.1.109)
    Short name:
    AST
    Alternative name(s):
    AOST
    Gene namesi
    Name:astA
    Synonyms:ydjV
    Ordered Locus Names:b1747, JW1736
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13998. astA.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Arginine N-succinyltransferasePRO_0000064712Add
    BLAST

    Proteomic databases

    PRIDEiP0AE37.

    Expressioni

    Inductioni

    By nitrogen starvation, and arginine. Induced at stationary phase by sigma S.1 Publication

    Gene expression databases

    GenevestigatoriP0AE37.

    Interactioni

    Protein-protein interaction databases

    IntActiP0AE37. 6 interactions.
    STRINGi511145.b1747.

    Structurei

    3D structure databases

    ProteinModelPortaliP0AE37.
    SMRiP0AE37. Positions 1-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3138.
    HOGENOMiHOG000258231.
    KOiK00673.
    OMAiRFFSMEF.
    OrthoDBiEOG6XQ3H4.
    PhylomeDBiP0AE37.

    Family and domain databases

    Gene3Di3.40.630.30. 2 hits.
    HAMAPiMF_01171. AstA.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR007041. Arg_N-succinylTrfase_Ast/AOST.
    IPR017650. Arginine_N-succinylTrfase_AstA.
    [Graphical view]
    PfamiPF04958. AstA. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    TIGRFAMsiTIGR03243. arg_catab_AOST. 1 hit.
    TIGR03244. arg_catab_AstA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0AE37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMVIRPVERS DVSALMQLAS KTGGGLTSLP ANEATLSARI ERAIKTWQGE    50
    LPKSEQGYVF VLEDSETGTV AGICAIEVAV GLNDPWYNYR VGTLVHASKE 100
    LNVYNALPTL FLSNDHTGSS ELCTLFLDPD WRKEGNGYLL SKSRFMFMAA 150
    FRDKFNDKVV AEMRGVIDEH GYSPFWQSLG KRFFSMDFSR ADFLCGTGQK 200
    AFIAELMPKH PIYTHFLSQE AQDVIGQVHP QTAPARAVLE KEGFRYRNYI 250
    DIFDGGPTLE CDIDRVRAIR KSRLVEVAEG QPAQGDFPAC LVANENYHHF 300
    RVVLVRTDPA TERLILTAAQ LDALKCHAGD RVRLVRLCAE EKTA 344
    Length:344
    Mass (Da):38,456
    Last modified:December 6, 2005 - v1
    Checksum:i89C7BB412A880BEF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC74817.1.
    AP009048 Genomic DNA. Translation: BAE76517.1.
    PIRiC64934.
    RefSeqiNP_416261.1. NC_000913.3.
    YP_490008.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC74817; AAC74817; b1747.
    BAE76517; BAE76517; BAE76517.
    GeneIDi12933241.
    946261.
    KEGGiecj:Y75_p1722.
    eco:b1747.
    PATRICi32118803. VBIEscCol129921_1819.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC74817.1 .
    AP009048 Genomic DNA. Translation: BAE76517.1 .
    PIRi C64934.
    RefSeqi NP_416261.1. NC_000913.3.
    YP_490008.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P0AE37.
    SMRi P0AE37. Positions 1-335.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P0AE37. 6 interactions.
    STRINGi 511145.b1747.

    Proteomic databases

    PRIDEi P0AE37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC74817 ; AAC74817 ; b1747 .
    BAE76517 ; BAE76517 ; BAE76517 .
    GeneIDi 12933241.
    946261.
    KEGGi ecj:Y75_p1722.
    eco:b1747.
    PATRICi 32118803. VBIEscCol129921_1819.

    Organism-specific databases

    EchoBASEi EB3754.
    EcoGenei EG13998. astA.

    Phylogenomic databases

    eggNOGi COG3138.
    HOGENOMi HOG000258231.
    KOi K00673.
    OMAi RFFSMEF.
    OrthoDBi EOG6XQ3H4.
    PhylomeDBi P0AE37.

    Enzyme and pathway databases

    UniPathwayi UPA00185 ; UER00279 .
    BioCyci EcoCyc:ARGSUCCTRAN-MONOMER.
    ECOL316407:JW1736-MONOMER.
    MetaCyc:ARGSUCCTRAN-MONOMER.

    Miscellaneous databases

    PROi P0AE37.

    Gene expression databases

    Genevestigatori P0AE37.

    Family and domain databases

    Gene3Di 3.40.630.30. 2 hits.
    HAMAPi MF_01171. AstA.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR007041. Arg_N-succinylTrfase_Ast/AOST.
    IPR017650. Arginine_N-succinylTrfase_AstA.
    [Graphical view ]
    Pfami PF04958. AstA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    TIGRFAMsi TIGR03243. arg_catab_AOST. 1 hit.
    TIGR03244. arg_catab_AstA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    3. "Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli."
      Schneider B.L., Kiupakis A.K., Reitzer L.J.
      J. Bacteriol. 180:4278-4286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "ArgR-independent induction and ArgR-dependent superinduction of the astCADBE operon in Escherichia coli."
      Kiupakis A.K., Reitzer L.
      J. Bacteriol. 184:2940-2950(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    5. "Prediction of the structure and function of AstA and AstB, the first two enzymes of the arginine succinyltransferase pathway of arginine catabolism."
      Shirai H., Mizuguchi K.
      FEBS Lett. 555:505-510(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING, REACTION MECHANISM.

    Entry informationi

    Entry nameiASTA_ECOLI
    AccessioniPrimary (citable) accession number: P0AE37
    Secondary accession number(s): P76218, Q2MB39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3