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Protein

Arginine ABC transporter permease protein ArtM

Gene

artM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:ARTM-MONOMER.
ECOL316407:JW0845-MONOMER.
MetaCyc:ARTM-MONOMER.

Protein family/group databases

TCDBi3.A.1.3.3. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine ABC transporter permease protein ArtM
Gene namesi
Name:artM
Ordered Locus Names:b0861, JW0845
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11627. artM.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515PeriplasmicSequence analysisAdd
BLAST
Transmembranei16 – 3621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini37 – 4913CytoplasmicSequence analysisAdd
BLAST
Transmembranei50 – 7021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini71 – 799PeriplasmicSequence analysis
Transmembranei80 – 10021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini101 – 15454CytoplasmicSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini176 – 18611PeriplasmicSequence analysisAdd
BLAST
Transmembranei187 – 20721HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini208 – 22215CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Arginine ABC transporter permease protein ArtMPRO_0000059957Add
BLAST

Proteomic databases

PaxDbiP0AE30.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (ArtP), two transmembrane proteins (ArtM and ArtQ) and two solute-binding proteins (ArtJ and ArtI).1 Publication

Protein-protein interaction databases

BioGridi4263352. 8 interactions.
DIPiDIP-48169N.
IntActiP0AE30. 2 interactions.
STRINGi511145.b0861.

Structurei

3D structure databases

ProteinModelPortaliP0AE30.
SMRiP0AE30. Positions 1-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 208197ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DMR. Bacteria.
COG4160. LUCA.
HOGENOMiHOG000267552.
InParanoidiP0AE30.
KOiK09998.
OMAiRSADQMF.
OrthoDBiEOG6MM1R5.
PhylomeDBiP0AE30.

Family and domain databases

Gene3Di1.10.3720.10. 1 hit.
InterProiIPR010065. AA_ABC_transptr_permease_3TM.
IPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01726. HEQRo_perm_3TM. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AE30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEYLPELMK GLHTSLTLTV ASLIVALILA LIFTIILTLK TPVLVWLVRG
60 70 80 90 100
YITLFTGTPL LVQIFLIYYG PGQFPTLQEY PALWHLLSEP WLCALIALSL
110 120 130 140 150
NSAAYTTQLF YGAIRAIPEG QWQSCSALGM SKKDTLAILL PYAFKRSLSS
160 170 180 190 200
YSNEVVLVFK STSLAYTITL MEVMGYSQLL YGRTYDVMVF GAAGIIYLVV
210 220
NGLLTLMMRL IERKALAFER RN
Length:222
Mass (Da):24,914
Last modified:December 6, 2005 - v1
Checksum:iE9AEF4221C662EDE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631Q → R in CAA60104 (PubMed:8501075).Curated
Sequence conflicti100 – 1001L → V in CAA60104 (PubMed:8501075).Curated
Sequence conflicti216 – 2161L → V in CAA60104 (PubMed:8501075).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86160 Genomic DNA. Translation: CAA60104.1.
U00096 Genomic DNA. Translation: AAC73948.1.
AP009048 Genomic DNA. Translation: BAA35575.1.
PIRiE64824.
RefSeqiNP_415382.1. NC_000913.3.
WP_000464491.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73948; AAC73948; b0861.
BAA35575; BAA35575; BAA35575.
GeneIDi949066.
KEGGiecj:JW0845.
eco:b0861.
PATRICi32116929. VBIEscCol129921_0890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86160 Genomic DNA. Translation: CAA60104.1.
U00096 Genomic DNA. Translation: AAC73948.1.
AP009048 Genomic DNA. Translation: BAA35575.1.
PIRiE64824.
RefSeqiNP_415382.1. NC_000913.3.
WP_000464491.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AE30.
SMRiP0AE30. Positions 1-214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263352. 8 interactions.
DIPiDIP-48169N.
IntActiP0AE30. 2 interactions.
STRINGi511145.b0861.

Protein family/group databases

TCDBi3.A.1.3.3. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0AE30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73948; AAC73948; b0861.
BAA35575; BAA35575; BAA35575.
GeneIDi949066.
KEGGiecj:JW0845.
eco:b0861.
PATRICi32116929. VBIEscCol129921_0890.

Organism-specific databases

EchoBASEiEB1584.
EcoGeneiEG11627. artM.

Phylogenomic databases

eggNOGiENOG4105DMR. Bacteria.
COG4160. LUCA.
HOGENOMiHOG000267552.
InParanoidiP0AE30.
KOiK09998.
OMAiRSADQMF.
OrthoDBiEOG6MM1R5.
PhylomeDBiP0AE30.

Enzyme and pathway databases

BioCyciEcoCyc:ARTM-MONOMER.
ECOL316407:JW0845-MONOMER.
MetaCyc:ARTM-MONOMER.

Miscellaneous databases

PROiP0AE30.

Family and domain databases

Gene3Di1.10.3720.10. 1 hit.
InterProiIPR010065. AA_ABC_transptr_permease_3TM.
IPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01726. HEQRo_perm_3TM. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Physical map location of the new artPIQMJ genes of Escherichia coli, encoding a periplasmic arginine transport system."
    Wissenbach U., Unden G.
    J. Bacteriol. 175:3687-3688(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / AN387.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "A third periplasmic transport system for L-arginine in Escherichia coli: molecular characterization of the artPIQMJ genes, arginine binding and transport."
    Wissenbach U., Six S., Bongaerts J., Ternes D., Steinwachs S., Unden G.
    Mol. Microbiol. 17:675-686(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiARTM_ECOLI
AccessioniPrimary (citable) accession number: P0AE30
Secondary accession number(s): P30862, P77311
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: February 17, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.