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Protein

Arabinose-proton symporter

Gene

araE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system).

GO - Molecular functioni

  • carbohydrate:proton symporter activity Source: GO_Central
  • fucose transmembrane transporter activity Source: EcoCyc
  • L-arabinose transmembrane transporter activity Source: EcoCyc
  • symporter activity Source: EcoCyc

GO - Biological processi

  • fucose transmembrane transport Source: EcoCyc
  • L-arabinose transmembrane transport Source: EcoCyc

Keywordsi

Biological processSugar transport, Symport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:ARAE-MONOMER
MetaCyc:ARAE-MONOMER

Protein family/group databases

TCDBi2.A.1.1.2 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Arabinose-proton symporter
Alternative name(s):
Arabinose transporter
Gene namesi
Name:araE
Ordered Locus Names:b2841, JW2809
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10056 araE

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 63PeriplasmicSequence analysisAdd BLAST13
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 91CytoplasmicSequence analysis7
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 114PeriplasmicSequence analysis2
Transmembranei115 – 135Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini136 – 154CytoplasmicSequence analysisAdd BLAST19
Transmembranei155 – 175Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini176 – 178PeriplasmicSequence analysis3
Transmembranei179 – 199Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini200 – 257CytoplasmicSequence analysisAdd BLAST58
Transmembranei258 – 278Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini279 – 297PeriplasmicSequence analysisAdd BLAST19
Transmembranei298 – 318Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini319 – 325CytoplasmicSequence analysis7
Transmembranei326 – 346Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini347 – 361PeriplasmicSequence analysisAdd BLAST15
Transmembranei362 – 382Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini383 – 404CytoplasmicSequence analysisAdd BLAST22
Transmembranei405 – 425Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini426 – 427PeriplasmicSequence analysis2
Transmembranei428 – 446Helical; Name=12Sequence analysisAdd BLAST19
Topological domaini447 – 472CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000502891 – 472Arabinose-proton symporterAdd BLAST472

Proteomic databases

PaxDbiP0AE24
PRIDEiP0AE24

Interactioni

Protein-protein interaction databases

BioGridi4259474, 16 interactors
STRINGi316385.ECDH10B_3013

Structurei

3D structure databases

ProteinModelPortaliP0AE24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QNK Bacteria
ENOG410XNQK LUCA
HOGENOMiHOG000202868
InParanoidiP0AE24
KOiK02100
OMAiSWGVVVW
PhylomeDBiP0AE24

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0AE24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTINTESAL TPRSLRDTRR MNMFVSVAAA VAGLLFGLDI GVIAGALPFI
60 70 80 90 100
TDHFVLTSRL QEWVVSSMML GAAIGALFNG WLSFRLGRKY SLMAGAILFV
110 120 130 140 150
LGSIGSAFAT SVEMLIAARV VLGIAVGIAS YTAPLYLSEM ASENVRGKMI
160 170 180 190 200
SMYQLMVTLG IVLAFLSDTA FSYSGNWRAM LGVLALPAVL LIILVVFLPN
210 220 230 240 250
SPRWLAEKGR HIEAEEVLRM LRDTSEKARE ELNEIRESLK LKQGGWALFK
260 270 280 290 300
INRNVRRAVF LGMLLQAMQQ FTGMNIIMYY APRIFKMAGF TTTEQQMIAT
310 320 330 340 350
LVVGLTFMFA TFIAVFTVDK AGRKPALKIG FSVMALGTLV LGYCLMQFDN
360 370 380 390 400
GTASSGLSWL SVGMTMMCIA GYAMSAAPVV WILCSEIQPL KCRDFGITCS
410 420 430 440 450
TTTNWVSNMI IGATFLTLLD SIGAAGTFWL YTALNIAFVG ITFWLIPETK
460 470
NVTLEHIERK LMAGEKLRNI GV
Length:472
Mass (Da):51,684
Last modified:December 6, 2005 - v1
Checksum:i411990A441D44393
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26 – 28SVA → YDR in CAA25075 (PubMed:6319708).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03732 Genomic DNA Translation: AAA23469.1
U29581 Genomic DNA Translation: AAB40488.1
X00272 Genomic DNA Translation: CAA25075.1
U00096 Genomic DNA Translation: AAC75880.1
AP009048 Genomic DNA Translation: BAE76910.1
PIRiB26430
RefSeqiNP_417318.1, NC_000913.3
WP_000256438.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75880; AAC75880; b2841
BAE76910; BAE76910; BAE76910
GeneIDi947341
KEGGiecj:JW2809
eco:b2841
PATRICifig|1411691.4.peg.3893

Similar proteinsi

Entry informationi

Entry nameiARAE_ECOLI
AccessioniPrimary (citable) accession number: P0AE24
Secondary accession number(s): P09830, Q2M9Z6, Q46937
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: April 25, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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